WordNet
- locate (a moving entity) by means of a tracking system such as radar
- win something through ones efforts; "I acquired a passing knowledge of Chinese"; "Gain an understanding of international finance" (同)win, gain
- gotten through environmental forces; "acquired characteristics (such as a suntan or a broken nose) cannot be passed on"
PrepTutorEJDIC
- (不断の努力・習慣などで)…'を'『習得する』,身につける / 〈財産・権利など〉'を'手に入れる,取得する
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English Journal
- Acquired cholesteatoma presenting as a pars squamosa temporal bone mass.
- Vanison C, Jaryszak EM, Yaun AL, Preciado DA.Author information Department of Otolaryngology-Head and Neck Surgery, Northwestern Memorial Hospital, Chicago, IL, USA.AbstractAcquired cholesteatomas typically arise in the middle ear and mastoid cavities; they rarely present elsewhere. We describe a case of acquired cholesteatoma that presented as a large mass of the pars squamosa of the temporal bone in a 16-year-old girl. The mass was surgically removed without complication. To the best of our knowledge, this is only the second reported case of an acquired cholesteatoma in the lateral temporal bone.
- Ear, nose, & throat journal.Ear Nose Throat J.2014 Feb;93(2):E17-9.
- Acquired cholesteatomas typically arise in the middle ear and mastoid cavities; they rarely present elsewhere. We describe a case of acquired cholesteatoma that presented as a large mass of the pars squamosa of the temporal bone in a 16-year-old girl. The mass was surgically removed without complica
- PMID 24526485
- Activation of the EGFR/Akt/NF-κB/cyclinD1 survival signaling pathway in human cholesteatoma epithelium.
- Liu W, Yin T, Ren J, Li L, Xiao Z, Chen X, Xie D.Author information Department of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Hunan, 410011, Changsha, China.AbstractCholesteatoma is a benign keratinizing squamous epithelial lesion characterized by the hyper-proliferation of keratinocytes with abundant production of keratin debris in the middle ear. The epidermal growth factor receptor (EGFR)/Akt/nuclear factor-kappa B (NF-κB)/cyclinD1 signaling pathway is one of the most important pathways in regulating cell survival and proliferation. We hypothesized that the EGFR/Akt/NF-κB/cyclinD1 signaling pathway may be activated and involved in the cellular hyperplasia mechanism in acquired cholesteatoma epithelium. Immunohistochemical staining of phosphorylated EGFR (p-EGFR), phosphorylated Akt (p-Akt), activated NF-κB and cyclinD1 protein was performed in 40 cholesteatoma samples and 20 samples of normal external auditory canal (EAC) epithelium. Protein expression of p-EGFR, p-Akt, activated NF-κB and cyclinD1 in cholesteatoma epithelium was significantly increased when compared with normal EAC epithelium (p < 0.01). In cholesteatoma epithelium, a significant positive association was observed between p-EGFR and p-Akt expression and between the expressions of p-Akt and NF-κB, NF-κB and cyclinD1, respectively (p < 0.01). No significant relationships were observed between the levels of investigated proteins and the degree of bone destruction (p > 0.05). The increased protein expression of p-EGFR, p-Akt, NF-κB and cyclinD1 and their associations in cholesteatoma epithelium suggest that the EGFR/Akt/NF-κB/cyclinD1 survival signaling pathway is active and may be involved in the regulatory mechanisms of cellular hyperplasia in cholesteatoma epithelium.
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.Eur Arch Otorhinolaryngol.2014 Feb;271(2):265-73. doi: 10.1007/s00405-013-2403-6. Epub 2013 Mar 5.
- Cholesteatoma is a benign keratinizing squamous epithelial lesion characterized by the hyper-proliferation of keratinocytes with abundant production of keratin debris in the middle ear. The epidermal growth factor receptor (EGFR)/Akt/nuclear factor-kappa B (NF-κB)/cyclinD1 signaling pathway is one
- PMID 23463347
- Expression of pattern recognition receptors in cholesteatoma.
- Lee HY, Park MS, Byun JY, Kim YI, Yeo SG.Author information Department of Otolaryngology, College of Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702, Korea.AbstractAlthough many immunologic mechanisms have been investigated in studies of the pathogenesis of cholesteatoma, the role of pattern recognition receptors (PRRs) has not been fully determined. Therefore, we assessed innate immune responses in patients with cholesteatoma. We prospectively evaluated 21 patients with acquired cholesteatoma between August 2010 and July 2012. Cholesteatoma specimens were obtained during surgery, and skin from the external meatus of each patient was used as a control. RNA was extracted from these tissue samples, followed by real-time PCR to quantitatively assess the relative expression of toll-like receptors (TLRs), NOD-like receptors (NLRs), retinoic acid-inducible gene (RIG)-I, NO synthase (NOS) and cytokines. The levels of TLR-2, -3, -4, -6, -7, and -10, NOD-2, and IL-1 and -8 mRNAs were significantly higher in the cholesteatoma than in the skin specimens (p < .05). The expression levels of TLR-2 and -3, RIG-I, IL-6, and TNF-α mRNAs were significantly higher in cholesteatomas from women than from men. The levels of TLR-8, NOD-2, IL-12, and TNF-α mRNAs were significantly higher in recurrent than in initial cholesteatoma specimens (p < .05). Hearing level did not correlate with the levels of expression of mRNAs encoding TLRs, NLRs, NOS, RIG-I and related cytokines (p > .05). In conclusion, alterations in innate immunity triggered by PRRs are important in the pathophysiology of cholesteatoma. Gender differences and frequency of surgery may affect the expression of PRRs in cholesteatomas.
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.Eur Arch Otorhinolaryngol.2014 Feb;271(2):245-53. doi: 10.1007/s00405-013-2402-7. Epub 2013 Feb 26.
- Although many immunologic mechanisms have been investigated in studies of the pathogenesis of cholesteatoma, the role of pattern recognition receptors (PRRs) has not been fully determined. Therefore, we assessed innate immune responses in patients with cholesteatoma. We prospectively evaluated 21 pa
- PMID 23440434
Japanese Journal
- 臨床 弛緩部型真珠腫を伴った多発性中耳真珠腫の2例
- 長谷川 陽一,山本 悦生,老木 浩之,田邉 牧人
- 耳鼻咽喉科臨床 105(9), 2012
- … We report herein on 2 of multiple cholesteatomas combined with attic cholesteatoma. … Microscopic examination of the tympanic membrane and CT scan of the temporal bone indicated attic cholesteatoma in each case. … Surgical exploration demonstrated the presence of another cholesteatoma and there was no epithelial continuity between the lesion and the attic cholesteatoma. …
- NAID 130002141251
- Animal models of middle ear cholesteatoma.
- Yamamoto-Fukuda Tomomi,Takahashi Haruo,Koji Takehiko
- Journal of Biomedicine & Biotechnology 2011, 394241, 2011
- … Middle ear acquired cholesteatoma is a pathological condition associated with otitis media, which may be associated with temporal bone resorption, otorrhea and hearing loss, and occasionally various other complications. … Cholesteatoma is characterized by the enhanced proliferation of epithelial cells with aberrant morphologic characteristics. …
- NAID 120003255525
Related Links
- Acquired cholesteatomas make up 98% of all middle ear cholesteatomas and are almost always closely related to the tympanic membrane, from which most are thought to arise. Clinical presentationThe vast majority of acquired ...
- Acquired cholesteatoma in children: Strategies and medium-term results. Eur Ann Otorhinolaryngol Head Neck Dis. 2012 Apr 2. [Medline]. Yehudai N, Most T, Luntz M. Risk factors for sensorineural hearing loss in pediatricInt J . ...
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- 関
- acquisition、gain、get、obtain、procure、procurement、yield