出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/04/25 13:33:27」(JST)
| Acid phosphatase | |||||||||
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Acid phosphatase tetramer, Human prostate gland
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| Identifiers | |||||||||
| EC number | 3.1.3.2 | ||||||||
| CAS number | 9001-77-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Acid phosphatase (EC 3.1.3.2, acid phosphomonoesterase, phosphomonoesterase, glycerophosphatase, acid monophosphatase, acid phosphohydrolase, acid phosphomonoester hydrolase, uteroferrin, acid nucleoside diphosphate phosphatase, orthophosphoric-monoester phosphohydrolase (acid optimum)) is a phosphatase, a type of enzyme, used to free attached phosphoryl groups from other molecules during digestion. It can be further classified as a phosphomonoesterase. Acid phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum.[1] This enzyme is present in many animal and plant species.[2]
Different forms of acid phosphatase are found in different organs, and their serum levels are used to evaluate the success of the surgical treatment of prostate cancer.[1] In the past, they were also used to diagnose this type of cancer.
It's also used as a cytogenetic marker to distinguish the two different lineages of Acute Lymphoblastic Leukemia(ALL) : B-ALL ( a leukemia of B Lymphocytes ) is Acid-Phosphatase negative , T-ALL ( originating instead from T Lymphocytes ) is acid-phosphatase positive .
Acid phosphatase catalyzes the following reaction at an optimal acidic pH (below 7):
Phosphatase enzymes are also used by soil microorganisms to access organically bound phosphate nutrients. An assay on the rates of activity of these enzymes may be used to ascertain biological demand for phosphates in the soil.
Some plant roots, especially cluster roots, exude carboxylates that perform acid phosphatase activity, helping to mobilise phosphorus in nutrient-deficient soils.
Certain bacteria like Nocardia, can degrade this enzyme and utilize it as a carbon source.
Tartrate-resistant acid phosphatase may be used as a biochemical marker of osteoclast function during the process of bone resorption.[3]
The following genes encode the polypeptide components for various acid phosphatase isoenzymes.
Hydrolase: esterases (EC 3.1)
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| 3.1.1: Carboxylic ester hydrolases |
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| 3.1.2: Thioesterase |
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| 3.1.3: Phosphatase |
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| 3.1.4: Phosphodiesterase |
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| 3.1.6: Sulfatase |
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| Nuclease (includes deoxyribonuclease |
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Enzymes
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| リンク元 | 「酸性ホスファターゼ」 |
| 拡張検索 | 「tartrate-resistant acid phosphatase」「prostatic acid phosphatase」「serum acid phosphatase」「acid phosphatase test for seminal stains」 |
| 関連記事 | 「phosphatase」 |
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