WordNet

a breakdown of a cell layer in the epidermis (as in pemphigus)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/19 15:53:22」(JST)

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Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes,^[1] seen in diseases such as pemphigus vulgaris.^[2] It is absent in bullous pemphigoid, making it useful for differential diagnosis.

This histological feature is also seen in herpes simplex infections (HSV 1 and 2).

References

^ Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
^ Medical Dictionary Entry

UpToDate Contents

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1. 皮膚の水疱を有する患者に対するアプローチ approach to the patient with cutaneous blisters
2. 水疱性類天疱瘡および粘膜類天疱瘡の臨床的特徴および診断 clinical features and diagnosis of bullous pemphigoid and mucous membrane pemphigoid
3. ポルフィリン症：概要 porphyrias an overview
4. 後天性表皮水疱症 epidermolysis bullosa acquisita
5. Peeling skin syndrome

English Journal

No evidence of apoptotic cells in pemphigus acantholysis.

Janse IC, van der Wier G, Jonkman MF, Pas HH, Diercks GF.
The Journal of investigative dermatology.J Invest Dermatol.2014 Jul;134(7):2039-41. doi: 10.1038/jid.2014.60. Epub 2014 Jan 31.
PMID 24487306

Cantharidin: a comprehensive review of the clinical literature.

Torbeck R, Pan M, DeMoll E, Levitt J1.
Dermatology online journal.Dermatol Online J.2014 Jun 15;20(6). pii: http://www.escholarship.org/uc/item/45r512w0.
Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal of warts, molluscum contagiosum (MC), calluses, and acquired perforating dermatoses. Objective: To provide a comprehensive literature review of the efficacy and s
PMID 24945640

Pagetoid Spread of Bladder Urothelial Carcinoma to the Vagina and Vulva.

Lu B1, Liang Y.
Journal of lower genital tract disease.J Low Genit Tract Dis.2014 May 30. [Epub ahead of print]
OBJECTIVE: To study the clinicopathologic features of a rare disease of pagetoid urothelial intraepithelial neoplasia (PUIN) in the vulva.MATERIALS AND METHODS: We reviewed a case of PUIN in a Chinese woman with a long history of bladder urothelial carcinoma.RESULTS: The patient presented with vulva
PMID 24886870

Japanese Journal

Detection of antibodies against the non-calcium-dependent epitopes of desmoglein 3 in pemphigus vulgaris and their pathogenic significance

Kamiya K,Aoyama Y,Shirafuji Y,Hamada T,Morizane S,Fujii K,Hisata K,Iwatsuki K
British Journal of Dermatology 167(2), 252-261, 2012-08
… EDTA-treated Dsg3 baculoproteins adsorbed anti-Dsg3 serum antibodies against the non-Ca2+-dependent epitopes, but the remnant PV antibodies retained the ability to induce acantholysis in the dissociation assay. …
NAID 120005232494

皮膚, 口腔病変を認めず, 診断に苦慮した食道天疱瘡の1例

田口純,石橋陽子,菅井望,関英幸,三浦淳彦,藤田淳,鈴木潤一,鈴木昭,深澤雄一郎
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 52(8), 1866-1873, 2010-08-20
症例は75歳女性．嚥下困難，食欲不振と唾液が常に流れてくる症状で近医を受診．上部消化管内視鏡検査で，逆流性食道炎と慢性胃炎の診断でプロトンポンプ阻害薬（PPI）を処方されていた．しかし，症状の改善を認めず当科を受診．難治性かつ上部消化管内視鏡検査にて食道粘膜に非連続性に地図状のびらんが散在し，易粘膜剥離も認めたため食道天疱瘡を疑った．抗デスモグレイン（Dsg）3抗体価が23 Indexと陽性であり …
NAID 10026910868

［依頼総説］カンナビノイド作動薬, バニロイド作動薬によるダリエー病治療薬の開発

高橋健造,Takahashi Kenzo,琉球大学医学部大学院医学研究科皮膚病態制御学講座,Department of Dermatology Graduate School of Medicine University of the Ryukyus
琉球医学会誌 = Ryukyu Medical Journal 29(3･4), 17-21, 2010
… Due to the decrease in the active SERCA2 protein, the affected keratinocytes cannot conduct normal Ca metabolism and result in the individual dyskeratosis and acantholysis. …
NAID 120003993929

Related Pictures

★リンクテーブル★

リンク元	「棘融解」「acanth」「acantholytic」

「棘融解」

Acantholysis
	Foot-and-mouth disease - acantholysis in a sample of a skin vesicle: Necrosis of the stratum spinosum can be observed, and keratinocytes floating in the vesicular fluid (spongiosa).
Classification and external resources
ICD-10	L11.9 (ILDS L11.900)
DiseasesDB	31172