WordNet

the process of declining from a higher to a lower level of effective power or vitality or essential quality (同)devolution
passing from a more complex to a simpler biological form (同)retrogression

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退歩,退化,墜落

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1. 腫瘍随伴性小脳変性症 paraneoplastic cerebellar degeneration
2. 加齢黄斑変性：治療および予防 age related macular degeneration treatment and prevention
3. 成人における小脳性運動失調の概要 overview of cerebellar ataxia in adults
4. パーキンソン病の診断 diagnosis of parkinson disease
5. 大脳皮質基底核変性症 corticobasal degeneration

English Journal

Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain.

Lima-Ojeda JM1, Vogt MA, Pfeiffer N, Dormann C, Köhr G, Sprengel R, Gass P, Inta D.Author information 1RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.AbstractNMDA receptor (NMDAR) antagonists like ketamine and MK-801 possess remarkable antidepressant effects with fast onset. However, they over-stimulate the retrosplenial cortex, evoking psychosis-like effects and neuronal injury, revealed by de novo induction of the heat shock protein 70 (Hsp70). Moreover, early in the development MK-801 triggers widespread cortical apoptosis, inducing extensive caspase-3 expression. Altogether these data raise strong concerns on the clinical applicability of NMDAR antagonist therapies. Therefore, the development of novel therapeutics targeting more specifically NMDAR to avoid psychotomimetic effects is necessary. Here we investigated a GluN2B (NR2B) antagonist in behavioral and neurotoxicity paradigms in rats to assess its potential as possible alternative to unspecific NMDA receptor antagonists. We found that treatment with the GluN2B specific antagonist Ro 25-6981 evoked robust antidepressant-like effects. Moreover, Ro 25-6981 did not cause hyperactivity as displayed after treatment with unspecific NMDAR antagonists, a correlate of psychosis-like effects in rodents. Additionally, Ro 25-6981, unlike MK-801, did not induce caspase-3 and HSP70 expression, markers of neurotoxicity in the perinatal and adult brain, respectively. Moreover, unexpectedly, in the adult retrosplenial cortex Ro 25-6981 pretreatment significantly reduced MK-801-triggered neurotoxicity. Our results suggest that GluN2B antagonists may represent valuable alternatives to unspecific NMDAR antagonists with robust antidepressant efficacy and a more favorable side-effect profile.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2013 Aug 1;45:28-33. doi: 10.1016/j.pnpbp.2013.04.017. Epub 2013 Apr 30.
NMDA receptor (NMDAR) antagonists like ketamine and MK-801 possess remarkable antidepressant effects with fast onset. However, they over-stimulate the retrosplenial cortex, evoking psychosis-like effects and neuronal injury, revealed by de novo induction of the heat shock protein 70 (Hsp70). Moreove
PMID 23643674

Euphorbia tirucalli L.-comprehensive characterization of a drought tolerant plant with a potential as biofuel source.

Hastilestari BR1, Mudersbach M, Tomala F, Vogt H, Biskupek-Korell B, Van Damme P, Guretzki S, Papenbrock J.Author information 1Institute of Botany, Gottfried Wilhelm Leibniz University Hannover, Hannover, Germany.AbstractOf late, decrease in mineral oil supplies has stimulated research on use of biomass as an alternative energy source. Climate change has brought problems such as increased drought and erratic rains. This, together with a rise in land degeneration problems with concomitant loss in soil fertility has inspired the scientific world to look for alternative bio-energy species. Euphorbia tirucalli L., a tree with C3/CAM metabolism in leaves/stem, can be cultivated on marginal, arid land and could be a good alternative source of biofuel. We analyzed a broad variety of E. tirucalli plants collected from different countries for their genetic diversity using AFLP. Physiological responses to induced drought stress were determined in a number of genotypes by monitoring growth parameters and influence on photosynthesis. For future breeding of economically interesting genotypes, rubber content and biogas production were quantified. Cluster analysis shows that the studied genotypes are divided into two groups, African and mostly non-African genotypes. Different genotypes respond significantly different to various levels of water. Malate measurement indicates that there is induction of CAM in leaves following drought stress. Rubber content varies strongly between genotypes. An investigation of the biogas production capacities of six E. tirucalli genotypes reveals biogas yields higher than from rapeseed but lower than maize silage.
PloS one.PLoS One.2013 May 3;8(5):e63501. doi: 10.1371/journal.pone.0063501. Print 2013.
Of late, decrease in mineral oil supplies has stimulated research on use of biomass as an alternative energy source. Climate change has brought problems such as increased drought and erratic rains. This, together with a rise in land degeneration problems with concomitant loss in soil fertility has i
PMID 23658836

Arthroscopically assisted 2-bundle anatomic reduction of acute acromioclavicular joint separations: 58-month findings.

Venjakob AJ1, Salzmann GM, Gabel F, Buchmann S, Walz L, Spang JT, Vogt S, Imhoff AB.Author information 1Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.AbstractBACKGROUND: Currently, no clinical midterm results have been reported on arthroscopically assisted reduction of the acutely dislocated acromioclavicular (AC) joint using suture-button devices for fixation.
The American journal of sports medicine.Am J Sports Med.2013 Mar;41(3):615-21. doi: 10.1177/0363546512473438. Epub 2013 Jan 31.
BACKGROUND: Currently, no clinical midterm results have been reported on arthroscopically assisted reduction of the acutely dislocated acromioclavicular (AC) joint using suture-button devices for fixation.HYPOTHESIS: Athroscopically assisted reduction of the acutely dislocated AC joint yields satisf
PMID 23371472

Japanese Journal

A Slowly Progressive and Reproducible Animal Model of Intervertebral Disc Degeneration Characterized by MRI, X-Ray, and Histology

SOBAJIMA Satoshi,KOMPEL John F.,KIM Joseph S.,WALLACH Corey J.,ROBERTSON Douglas D.,VOGT Molly T.,KANG James D.,GILBERTSON Lars G.
Spine 30(1), 15-24, 2005-01-01
NAID 10016133069

動脈硬化症モデルとしての組織培養

神尾昭紀,白石昌之,舌間憲士,竹林茂夫
動脈硬化 7(1), 85-91, 1979
… The modified Dulbecco-Vogt culture medium containing 10% newborn calf serum and 1% antibiotic-antimycotic solution was changed every third day. … The present in vitro culture system dealed secretion of extracellular material and cellular degeneration led to the formation of nodular protrusions which may be convenience for the study of the morphological features of atherosclerotic lesions. …
NAID 130004885191

Ueber die Nissl-degeneration nach Kleinhitrnläsionen. I. Teil. Ueber die Nissl-degeneration in den Vestibularisendkernen und anderswo nach Kleinhirnläsionen

Yoshida Isao
岡山医学会雑誌 36(416), 749-775, 1924-09-30
… globosus entsprechende graue Masse auf der linken Seite zerstört, und als sekundärc Veränderung wurde die Degeneration der Zellen des Deitersschen und Bechterewschen Kerns sowie der grauen Substanz der Radix sp. … dentatus zerstört, und infolgedessen wurde die Degeneration der Zellen des Deitersschen und Bechterewschen Kerns sowie der grauen Masse der Radix sp. … Im Versuch 6 wurde der linke Flocculus exstirpiert, aber im Vestibularisendgebiete wurde keine Degeneration gefunden. …
NAID 120003752028