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the basic unit of money in Bangladesh; equal to 100 paisa

PrepTutorEJDIC

tantalumの化学記号

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1. グリコーゲン分枝酵素欠損症（糖原病IV型、アンダーセン病） glycogen branching enzyme deficiency glycogen storage disease iv andersen disease
2. グリコーゲン脱分枝酵素欠損症（糖原病III型） glycogen debrancher deficiency glycogen storage disease iii
3. 偽ポルフィリン症 pseudoporphyria
4. α-1アンチトリプシン欠乏の肺外症状 extrapulmonary manifestations of alpha 1 antitrypsin deficiency
5. リソソーム酸マルターゼ欠損症（糖原病II型、ポンペ病） lysosomal acid maltase deficiency glycogen storage disease ii pompe disease

English Journal

Degradation of raw or film-incorporated beta-cyclodextrin by enzymes and colonic bacteria.

Fetzner A, Böhm S, Schreder S, Schubert R.Author information Merck KGaA, Department of Pharmaceutical Development, Darmstadt, Germany.Abstractbeta-cyclodextrin (beta-CD) is a suitable excipient for peroral use, which improves the solubility of lipophilic drugs, as well as for colon-specific drug release when it is mixed with coating polymers. The first aim of this work was to examine the suitability of various enzymes as a simple in vitro model for the glycolytic activity in the human colon. alpha-Amylase (source Aspergillus oryzae) and taka diastase (source A. oryzae) showed remarkable degradation capacity of free beta-CD, whereas other alpha-amylases (sources Bacillus subtilis or Hog pancreas) were found to be unsuitable. The next aim was to find out if film-incorporated beta-CD is also degraded by these enzymes. Therefore, diffusion studies of 5-aminosalicylic acid (5-ASA) through Eudragit RS or Eudragit NE films containing beta-CD were performed with taka diastase present in the buffer medium. Pronounced diffusion of the drug through the Eudragit RS film was found only when swelling excipients like crosslinked sodium carboxymethylcellulose (CMC-CL sodium) or polyvinylpyrrolidone (PVP 25) were present in the film, indicating enhanced accessibility of beta-CD by the enzyme. Films containing CMC-CL without beta-CD showed even higher permeability, which also points to enzymatic degradation of CMC-CL. Permeabilization by taka diastase of Eudragit NE films without swelling agents correlated with the beta-CD content, whereas control films containing talcum remained impermeable upon enzyme action. Furthermore, the beta-CD degradation capacity of colonic bacteria like Escherichia fergusonii, Serratia odorifera or Proteus mirabilis was examined with beta-CD coatings on tablets, which contained bisoprolol as a model drug. Tablets with beta-CD-containing Eudragit RS coatings showed the highest drug release upon incubation with P. mirabilis. The moderate drug release by E. fergusonii could be increased almost to the same level when the bacteria were pre-incubated for 24 h in medium containing 2.5 mg/ml beta-CD, indicating the induction of glycolytic enzymes by beta-CD in this colonic bacteria strain.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2004 Jul;58(1):91-7.
beta-cyclodextrin (beta-CD) is a suitable excipient for peroral use, which improves the solubility of lipophilic drugs, as well as for colon-specific drug release when it is mixed with coating polymers. The first aim of this work was to examine the suitability of various enzymes as a simple in vitro
PMID 15207542

Reversed-phase liquid chromatography on an amide stationary phase for the determination of the B group vitamins in baby foods.

Viñas P, López-Erroz C, Balsalobre N, Hernández-Córdoba M.Author information Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, E-30071 Murcia, Spain.AbstractA liquid chromatographic method for the separation and determination of several water-soluble vitamins of the B group is proposed. The procedure is based on the use of a new amide-based stationary phase, which avoids the need of using the ion-pair technique, leading to narrower peaks and a simpler mobile phase. Analyses were performed by gradient elution with acetonitrile-phosphate buffer as mobile phase and using a photodiode array detector. Specificity was demonstrated by the retention characteristics, UV spectra and by comparing the peak purity index with commercial standards. Linearity, precision, recovery and sensitivity were satisfactory. The vitamins are extracted from the baby food using a single digestion with hydrochloric acid followed by enzymatic digestion with taka-diastase. The method was successfully applied to the determination of nine vitamins: thiamine, riboflavin, nicotinamide, nicotinic acid, pyridoxine, pyridoxal, folic acid, cyanocobalamine and inosine in different baby foods as infant formulas, cereals and fruit products. Validation was performed using two certified reference materials.
Journal of chromatography. A.J Chromatogr A.2003 Jul 25;1007(1-2):77-84.
A liquid chromatographic method for the separation and determination of several water-soluble vitamins of the B group is proposed. The procedure is based on the use of a new amide-based stationary phase, which avoids the need of using the ion-pair technique, leading to narrower peaks and a simpler m
PMID 12924553

Drug eruption (erythema multiforme type) due to a digestive enzyme drug.

Miyoshi H, Kanzaki T.Author information Department of Dermatology, Kagoshima University Faculty of Medicine, Japan.AbstractAn 84-year-old Japanese male had pruritic indurated erythema on his upper limb and left lower abdomen, which had developed abruptly two months before visiting our hospital. Hematological examination showed eosinophilia, 550/mm3. Histopathological findings were suggestive of erythema multiforme in response to a drug. By means of patch tests and a p.o. challenge test, Aczym, a digestive enzyme drug, was shown to be the cause of his condition. Further study revealed that the specific ingredients involved were pancreatin and Taka-diastase. An eruption resulting from ingestion of a digestive enzyme drug has not previously been reported.
The Journal of dermatology.J Dermatol.1998 Jan;25(1):28-31.
An 84-year-old Japanese male had pruritic indurated erythema on his upper limb and left lower abdomen, which had developed abruptly two months before visiting our hospital. Hematological examination showed eosinophilia, 550/mm3. Histopathological findings were suggestive of erythema multiforme in re
PMID 9519606

Japanese Journal

高安右人と高峰譲吉 : 金沢発, 世界に名を残した2人の学者

松原純一
日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery 12(6), 563-569, 2003-10-25
NAID 10013950935

食肉タンパク質におよぼすイチジク果実プロテアーゼの基本的性状

孫成春,泉本勝利,宮本拓,宮瀬こころ
岡山大学農学部学術報告 92(1), 53-56, 2003-02
… The activity of fig 1g was equivalent to the protease of Taka-diastase 10mg. …
NAID 120002311222

かるかんの人工消化試験について

大山重信,寿島節子
鹿児島県立短期大学紀要. 自然科学篇 41, 15-18, 1990-12-15
先に筆者らは鹿児島の代表的郷土食品の一つであるかるかんをとりあげ, 筆者らなりにその起源について考察を試みるとともに, 一般成分や物性その他について調べて報告してきた。本報においては, かるかんのデンプンおよび蛋白質の消化率について人工消化試験を行った結果を述べることとする。
NAID 110000048661