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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/03 14:16:27」(JST)

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Sodium/glucose cotransporter 1 is a protein that in humans is encoded by the SLC5A1 gene.^[1]^[2]

Function

Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally related substances across cellular membranes. Two families of glucose transporter have been identified: the facilitated diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters' (Wright et al., 1994). The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells. [supplied by OMIM]^[2]

Cloning of the sodium-glucose cotransporter SGLT1

Co-transport proteins of mammalian cell membranes had eluded efforts of purification with classical biochemical methods until the late 1980s. These proteins had proven difficult to isolate because they contain hydrophilic and hydrophobic sequences and exist in membranes only in very low abundance (<0.2% of membrane proteins). The rabbit form of SGLT1 is the first mammalian co-transport protein ever to be cloned and sequenced, and this scientific break-through was reported in 1987.^[3] To circumvent the difficulties with traditional isolation methods, Swiss-born biochemist Matthias Hediger and his collaborators at UCLA used a novel technique of expression cloning. They size-fractionated large amounts of rabbit intestinal mRNA with a preparative gel electrophoresis device developed by Hediger. These size fractions were then sequentially injected into Xenopus oocytes to ultimately find the RNA species that induced the expression of sodium-glucose cotransport.^[4]

Interactions

SLC5A1 has been shown to interact with PAWR.^[5]

References

^ Turk E, Martin MG, Wright EM (June 1994). "Structure of the human Na+/glucose cotransporter gene SGLT1". J Biol Chem 269 (21): 15204–9. PMID 8195156.
^ ^a ^b "Entrez Gene: SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1".
^ by Stice L, Steven Ph.D.
^ Hediger MA, Coady MJ, Ikeda TS, Wright EM (1987). "Expression cloning and cDNA sequencing of the Na+/glucose co-transporter". Nature 330 (6146): 379–81. doi:10.1038/330379a0. PMID 2446136.
^ Xie J, Guo Q (July 2004). "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane". J. Biol. Chem. 279 (27): 28266–75. doi:10.1074/jbc.M401495200. PMID 15090548.

UpToDate Contents

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1. Chapter 3B：近位尿細管におけるナトリウム輸送能の優越性 chapter 3b primacy of sodium transport in proximal function
2. 消化管の発達に関する概要 overview of the development of the gastrointestinal tract
3. グリコーゲン代謝のその他の障害：GLUT2欠損症およびアルドラーゼA欠損症 other disorders of glycogen metabolism glut2 deficiency and aldolase a deficiency

English Journal

Pine bark extract inhibits glucose transport in enterocytes via mitogen-activated kinase and phosphoinositol 3-kinase.

El-Zein O, Kreydiyyeh SI.SourceDepartment of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
Nutrition (Burbank, Los Angeles County, Calif.).2011 Jun;27(6):707-12. Epub 2010 Sep 24.
PMID 20869203

Stimulation of the glucose carrier SGLT1 by JAK2.

Hosseinzadeh Z, Bhavsar SK, Shojaiefard M, Saxena A, Merches K, Sopjani M, Alesutan I, Lang F.SourceDepartment of Physiology I, University of Tubingen, Gmelinstr. 5, 72076 Tubingen, Germany.
Biochemical and biophysical research communications.2011 May 6;408(2):208-13. Epub 2011 Mar 21.
JAK2 (Janus kinase-2) overactivity contributes to survival of tumor cells and the (V617F)JAK2 mutant is found in the majority of myeloproliferative diseases. Tumor cell survival depends on availability of glucose. Concentrative cellular glucose uptake is accomplished by Na(+) coupled glucose transpo
PMID 21406183

Japanese Journal

口腔扁平上皮癌におけるEGFRとSGLT1の発現解析

花畑泰子
口腔病学会雑誌 78(1), 12-18, 2011-03-31
NAID 10028159154

インクレチン分泌のメカニズム (特集インクレチン研究と創薬への展開) -- (本論)

矢部大介,清野裕
最新医学 66(1), 33-41, 2011-01
NAID 40017657760

Related Pictures

Fig. 7. Glukosetransport durch das Epithel des SGLT2 inhibition — a novel strategy for Fig. 4. Mode of action of SGLT1 and SGLT2

★リンクテーブル★

リンク元	「グルコース」「ナトリウム・グルコース輸送体1」「ナトリウム・グルコース共輸送体1」「sodium-glucose cotransporter 1」
拡張検索	「SGLT1 gene」
関連記事	「SGLT」

「グルコース」

Solute carrier family 5 (sodium/glucose cotransporter), member 1
Identifiers
Symbols	SLC5A1 ; D22S675; NAGT; SGLT1
External IDs	OMIM: 182380 MGI: 107678 HomoloGene: 55456 ChEMBL: 4979 GeneCards: SLC5A1 Gene
Gene ontology
Molecular function	• glucose:sodium symporter activity; • protein binding;
Cellular component	• plasma membrane; • integral component of plasma membrane; • cell-cell junction; • apical plasma membrane; • brush border membrane; • extracellular vesicular exosome;
Biological process	• carbohydrate metabolic process; • sodium ion transport; • hexose transport; • glucose transport; • small molecule metabolic process; • intestinal absorption; • transmembrane transport;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: glucose, grape sugar, dextrose
商: ブドウ糖注、グルノン
関: GLUT、血中グルコース濃度、血糖値、GLUT; グルコース1-リン酸、グルコース6-リン酸

分子量

分子量：180 g/mol

血糖 100 mg/dl -> 1000 mg/l ; 1000 mg/l / 180 g/mol ≒5.6 mmol/l = 5.6 mM

尿細管におけるグルコースの再吸収 SP.801

近位尿細管における刷子縁で行われる。
管腔側に糖/Na+共輸送体 SGLT(SGLT1とSGLT2)が存在し、Naとグルコースを共輸送する
SGLT2がグルコースの取り込みに貢献している(低親和性、高用量の輸送担体)

	SGLT1	SGLT2
局在	近位尿細管	近位尿細管
	中間部(S2)	起始部(S1)
	終末部(S3)	起始部(S1)
グルコースの親和性	高親和性	低親和性