WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 18th letter of the Roman alphabet (同)r
ancient Egyptian sun god with the head of a hawk; a universal creator; he merged with the god Amen as Amen-Ra to become the king of the gods (同)Re
causing motion or action or change (同)actuating

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1. アテローム性腎動脈狭窄に起因する慢性腎疾患の臨床症状および診断 clinical manifestations and diagnosis of chronic kidney disease resulting from atherosclerotic renal artery stenosis
2. 腎血管性高血圧の診断 establishing the diagnosis of renovascular hypertension
3. 片側性アテローム性腎動脈狭窄症の治療 treatment of unilateral atherosclerotic renal artery stenosis
4. 両側性アテローム性腎動脈狭窄症および機能的単腎の狭窄の治療 treatment of bilateral atherosclerotic renal artery stenosis or stenosis to a solitary functioning kidney
5. 結節性硬化症：遺伝学、臨床的特徴、および診断 tuberous sclerosis complex genetics clinical features and diagnosis

The Ras GTPase-activating-like protein IQGAP1 is downregulated in human diabetic nephropathy and associated with ERK1/2 pathway activation.

Zhou H1, Yao C, Bian A, Qian J, Zhao X, Zhao Y, Wang W, Xing C.
Molecular and cellular biochemistry.Mol Cell Biochem.2014 Jun;391(1-2):21-5. doi: 10.1007/s11010-014-1982-x. Epub 2014 Feb 2.
Podocyte injury may contribute to the pathogenesis of diabetic nephropathy (DN), but the underlying mechanism of hyperglycemia induced podocyte damage is not fully understood. The Ras GTPase-activating-like protein IQGAP1 is associated to the slit diaphragm proteins and the actin cytoskeleton in pod
PMID 24488174

RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis.

Rowshanravan B, Woodcock SA, Botella JA, Kiermayer C, Schneuwly S, Hughes DA.
Journal of cell science.J Cell Sci.2014 May 9. [Epub ahead of print]
The GTPase Ras can either promote or inhibit cell survival. Inactivating mutations in RasGAP (vap), a Ras GTPase-activating protein, lead to age-related brain degeneration in Drosophila. Genetic interactions implicate the epidermal growth factor receptor (EGFR)-Ras pathway in promoting neurodegenera
PMID 24816559

Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR).

Mazhab-Jafari MT1, Marshall CB, Ho J, Ishiyama N, Stambolic V, Ikura M.
The Journal of biological chemistry.J Biol Chem.2014 May 2;289(18):12195-201. doi: 10.1074/jbc.C113.543736. Epub 2014 Mar 19.
Constitutively activated variants of small GTPases, which provide valuable functional probes of their role in cellular signaling pathways, can often be generated by mutating the canonical catalytic residue (e.g. Ras Q61L) to impair GTP hydrolysis. However, this general approach is ineffective for a
PMID 24648513