WordNet

the 18th letter of the Roman alphabet (同)r
ancient Egyptian sun god with the head of a hawk; a universal creator; he merged with the god Amen as Amen-Ra to become the king of the gods (同)Re

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resistance / 17歳以下父兄同伴映画の表示 / rook
radiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/12 22:25:15」(JST)

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Ras-GRF1 is a guanine nucleotide exchange factor. Its function is to release guanosine diphosphate, GDP, from the signaling protein RAS, thus increasing the activity of RAS by allowing it to bind to guanosine triphosphate, GTP, returning it to its active state. In this way, Ras-GRF1 has a key role in regulating the RAS signaling pathway. Ras-GRF1 knockout mice have been shown to have learning and memory deficits associated with dysregulation of this pathway.^[1] Ras-GRF1 has also been shown to be upstream from IGF1, allowing it to control growth in mice.^[2] Although it is sometimes known as CDC25, it should not be confused with Cdc25. Ras-GRF1 is a paternally expressed imprinted gene, meaning that only the paternal allele of the gene is translated into protein. Disruption of this epigenetic imprinting also produces learning and memory deficits in neonatal mice.^[3]

References

^ Fernandez-Medarde A, Porteros A, De Las Rivas J, Nunez A, Fuster JJ, Santos E (2007). "Laser microdissection and microarray analysis of the hippocampus of Ras-GRF1 knockout mice reveals gene expression changes affecting signal transduction pathways related to memory and learning". Neuroscience. 146: 272–285. doi:10.1016/j.neuroscience.2007.01.022.
^ Drake NM, Park YJ, Shirali AS, Cleland TA, Soloway PD (2009). "Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1". Mamm. Genome. 20 (9-10): 654–63. doi:10.1007/s00335-009-9192-7. PMC 2919583. PMID 19513790.
^ Drake NM, DeVito LM, Cleland TA, Soloway PD (2011). "Imprinted Rasgrf1 expression in neonatal mice affects olfactory learning and memory". Genes Brain Behav. 10 (4): 392–403. doi:10.1111/j.1601-183X.2011.00678.x. PMC 3091993. PMID 21251221.

External links

ras-GRF1 at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. アテローム性腎動脈狭窄に起因する慢性腎疾患の臨床症状および診断 clinical manifestations and diagnosis of chronic kidney disease resulting from atherosclerotic renal artery stenosis
2. 腎血管性高血圧の診断 establishing the diagnosis of renovascular hypertension
3. 両側性アテローム性腎動脈狭窄症および機能的単腎の狭窄の治療 treatment of bilateral atherosclerotic renal artery stenosis or stenosis to a solitary functioning kidney
4. 片側性アテローム性腎動脈狭窄症の治療 treatment of unilateral atherosclerotic renal artery stenosis
5. 急性および慢性腎臓病における高血圧の概要 overview of hypertension in acute and chronic kidney disease

English Journal

CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.

Jia XM1, Tang B2, Zhu LL3, Liu YH3, Zhao XQ4, Gorjestani S4, Hsu YM4, Yang L3, Guan JH3, Xu GT3, Lin X5.
The Journal of experimental medicine.J Exp Med.2014 Oct 20;211(11):2307-21. doi: 10.1084/jem.20132349. Epub 2014 Sep 29.
Dectin-1 functions as a pattern recognition receptor for sensing fungal infection. It has been well-established that Dectin-1 induces innate immune responses through caspase recruitment domain-containing protein 9 (CARD9)-mediated NF-κB activation. In this study, we find that CARD9 is dispensable f
PMID 25267792

R-Ras contributes to LTP and contextual discrimination.

Darcy MJ1, Jin SX1, Feig LA2.
Neuroscience.Neuroscience.2014 Sep 26;277:334-42. doi: 10.1016/j.neuroscience.2014.07.010. Epub 2014 Jul 17.
The ability to discriminate between closely related contexts is a specific form of hippocampal-dependent learning that may be impaired in certain neurodegenerative disorders such as Alzheimer's and Down Syndrome. However, signaling pathways regulating this form of learning are poorly understood. Pre
PMID 25043327

Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2.

Jin SX1, Bartolome C1, Arai JA1, Hoffman L2, Uzturk BG1, Kumar-Singh R1, Waxham MN2, Feig LA3.
The Journal of biological chemistry.J Biol Chem.2014 Jun 6;289(23):16551-64. doi: 10.1074/jbc.M114.557959. Epub 2014 Apr 22.
Ras-GRF1 (GRF1) and Ras-GRF2 (GRF2) constitute a family of similar calcium sensors that regulate synaptic plasticity. They are both guanine exchange factors that contain a very similar set of functional domains, including N-terminal pleckstrin homology, coiled-coil, and calmodulin-binding IQ domains
PMID 24755227

Japanese Journal

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

BUCHSBAUM R. J.
Mol Cell Biol 22, 4073-4085, 2002
NAID 80015373704

Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the Ras guanine nucleotide exchange factor CDC25^<Mm>/Ras-GRF1

GNESUTTA N.
J. Biol. Chem. 276, 39448-39454, 2001
NAID 30016321593

Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)

GIESE KP
Neuropharmacology 41, 791-800, 2001
NAID 30005202920

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関連記事	「RAS」「R」「GRF」「GR」

「RAS」

Ras protein-specific guanine nucleotide-releasing factor 1
Identifiers
Symbol	RASGRF1
Alt. symbols	GRF1
Entrez	5923
HUGO	9875
OMIM	606600
RefSeq	NM_153815
UniProt	Q13972
Other data
Locus	Chr. 15 q24