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1. アテローム性腎動脈狭窄に起因する慢性腎疾患の臨床症状および診断clinical manifestations and diagnosis of chronic kidney disease resulting from atherosclerotic renal artery stenosis [show details]
…to evaluate for renal artery stenosis, establishing the diagnosis of renal artery stenosis, and treatment of patients with unilateral or bilateral atherosclerotic renal artery stenosis are presented elsewhere …
2. 両側性アテローム性腎動脈狭窄症および機能的単腎の狭窄の治療treatment of bilateral atherosclerotic renal artery stenosis or stenosis to a solitary functioning kidney [show details]
… Renal artery stenosis is a relatively common finding in older patients with hypertension. However, renal artery stenosis is the primary cause of hypertension (ie, renovascular hypertension) only in certain …
3. 片側性アテローム性腎動脈狭窄症の治療treatment of unilateral atherosclerotic renal artery stenosis [show details]
… Renal artery stenosis is a relatively common finding in older patients with hypertension. However, renal artery stenosis is the primary cause of hypertension (ie, renovascular hypertension) only in certain …
4. 腎血管性高血圧の診断establishing the diagnosis of renovascular hypertension [show details]
…diagnostic tests for renovascular disease will be reviewed here. The clinical features and clues to a diagnosis of renovascular hypertension, as well as the treatment of renovascular hypertension and ischemic …
5. 二次性高血圧の評価evaluation of secondary hypertension [show details]
…hypertension will be reviewed here. Testing methods for renovascular hypertension and treatment of unilateral and bilateral atherosclerotic renal artery stenosis are discussed separately. There are a number …

English Journal

SH3-class Ras guanine nucleotide exchange factors are essential for Aspergillus fumigatus invasive growth.

Martin-Vicente A, Souza ACO, Al Abdallah Q, Ge W, Fortwendel JR.
Cellular microbiology. 2019 Jun;21(6)e13013.
Proper hyphal morphogenesis is essential for the establishment and progression of invasive disease caused by filamentous fungi. In the human pathogen Aspergillus fumigatus, signalling cascades driven by Ras and Ras-like proteins orchestrate a wide variety of cellular processes required for hyphal gr
PMID 30698898

Allosteric autoactivation of SOS and its kinetic mechanism.

Hoang HM, Umutesi HG, Heo J.
Small GTPases. 2019 Apr;()1-16.
Son of Sevenless (SOS), one of guanine nucleotide exchange factors (GEFs), activates Ras. We discovered that the allosteric domain of SOS yields SOS to proceed a previously unrecognized autoactivation kinetics. Its essential feature is a time-dependent acceleration of SOS feedback activation with a
PMID 30983499

RasGRP3 in peripheral blood mononuclear cells is associated with disease activity and implicated in the development of systemic lupus erythematosus.

An XJ, Xia Y, Li J, Dong LY, Wang YJ, Yang J, Li Y, Shen C, Zhang YM, Yang M, Tu YT, Yang L, Tao J.
American journal of translational research. 2019 ;11(3)1800-1809.
This study examined the relationship between the expression of Ras guanyl nucleotide-releasing protein 3 (RasGRP3) and disease activity in systemic lupus erythematosus (SLE) and explored the possible mechanisms in mice. We detected the expression of RasGRP3 in peripheral blood mononuclear cells (PB
PMID 30972203

Japanese Journal

Identification of the Gene Regulatory Region in Human rasgrp2 Gene in Vascular Endothelial Cells

Nagamine Kentaro,Matsuda Akira,Hori Takamitsu
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 33(7), 1138-1142, 2010
… Ras guanyl nucleotide-releasing protein 2 (RASGRP2) is a calcium- and diacylglycerol-responsive guanine nucleotide exchange factor. …
NAID 130000300277

関節リウマチ患者の末梢血単核球におけるRas guanyl nucleotide-releasing protein（RasGRP4）発現異常の検討

橋本陶子,保田晋助,片岡浩,堀田哲也,渥美達也,小池隆夫
日本臨床免疫学会総会抄録集 36(0), 119-119, 2008
【目的】末梢血におけるRasGRP4の発現細胞を同定し、関節リウマチ(RA)患者におけるRasGRP4の発現について検討する。【方法】健常人と患者の末梢血単核球分画よりCD14陽性細胞、T細胞、B細胞を分離し、PCRおよびreal-time PCRによるRasGRP4の遺伝子発現の検討、免疫組織染色およびフローサイトメトリーによる蛋白発現の検討を行った。末梢血単核球分画から合成したcDNAを用いて …
NAID 130006948919