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- 1. T細胞受容体シグナル伝達 t cell receptor signaling
English Journal
- Activation of Extracellular Signal-Regulated Kinase but Not of p38 Mitogen-Activated Protein Kinase Pathways in Lymphocytes Requires Allosteric Activation of SOS.
- Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP.SourceDepartment of Anatomy, University of California, San Francisco, San Francisco, California, USA.
- Molecular and cellular biology.Mol Cell Biol.2013 Jun;33(12):2470-84. doi: 10.1128/MCB.01593-12. Epub 2013 Apr 15.
- Thymocytes convert graded T cell receptor (TCR) signals into positive selection or deletion, and activation of extracellular signal-related kinase (ERK), p38, and Jun N-terminal protein kinase (JNK) mitogen-activated protein kinases (MAPKs) has been postulated to play a discriminatory role. Two fami
- PMID 23589333
- PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.
- Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA.SourceMoores Cancer Center, University of California San Diego, La Jolla, California, United States of America.
- PloS one.PLoS One.2013;8(4):e60226. doi: 10.1371/journal.pone.0060226. Epub 2013 Apr 2.
- Tumor inflammation, the recruitment of myeloid lineage cells into the tumor microenvironment, promotes angiogenesis, immunosuppression and metastasis. CD11b+Gr1lo monocytic lineage cells and CD11b+Gr1hi granulocytic lineage cells are recruited from the circulation by tumor-derived chemoattractants,
- PMID 23565202
Japanese Journal
- Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis
- Hashimoto Toko,Yasuda Shinsuke,Koide Hideyuki,Kataoka Hiroshi,Horita Tetsuya,Atsumi Tatsuya,Koike Takao
- Arthritis Research & Therapy 13(5), R154, 2011-09-20
- … Introduction: An unidentified population of peripheral blood mononuclear cells (PBMCs) express Ras guanine nucleotide releasing protein 4 (RasGRP4). … Methods: Monocytes and T cells were purified from PBMCs of normal individuals, and were evaluated for their expression of RasGRP4 mRNA/protein. … The levels of RasGRP4 transcripts were evaluated in the PBMCs from healthy volunteers and RA patients by real-time quantitative PCR. …
- NAID 120003945421
- PS-046 新規血管形成(vasculogenesis)におけるRasGRPファミリーの発現と機能解析(小児外科基礎研究(幹細胞),ポスターシンポジウム,病気の子供達に笑顔 小児外科に夢そして革新を,第47回 日本小児外科学会学術集会)
- 鈴木 完,岩中 督,金森 豊,杉山 正彦,古村 眞,寺脇 幹,小高 哲郎,田中 裕次郎
- 日本小児外科学会雑誌 46(3), 513, 2010-05-20
- NAID 110008015882
Related Links
- 「rasgrp」の用例・例文集 - RASGRP3はPRKCDと相互作用することが明らかにされている。 RASGRP3といったグアニンヌクレオチド交換因子は、GTP結合型を維持するためのGTPとの会合を促進することによってRAS活性化剤として働く。
- Buy RasGRP antibodies from Santa Cruz. Select a RasGRP antibody from 4 monoclonal and 5 polyclonal antibodies. RasGRP si/shRNA gene silencer products also available. ... 一次抗体：哺乳類 リン酸化型特異的抗体 IHC ...
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