PtdIns 4-kinase

• ホスファチジルイノシトール-4-キナーゼ

関

1-phosphatidylinositol 4-kinase、phosphatidylinositol 4-kinase、PI 4-kinase、PI4K

WordNet

1. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
2. the basic unit of money in Papua New Guinea

UpToDate Contents

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• 1. 心筋障害のバイオマーカーとしてのトロポニンおよびクレアチンキナーゼ troponins and creatine kinase as biomarkers of cardiac injury
• 2. 未分化リンパ腫キナーゼ（ALK）融合癌遺伝子陽性非小細胞肺癌 anaplastic lymphoma kinase alk fusion oncogene positive non small cell lung cancer
• 3. ホスホリラーゼbキナーゼ欠損症 phosphorylase b kinase deficiency
• 4. ホスホグリセリン酸キナーゼ欠損症およびホスホグリセリン酸ムターゼ欠損症 phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency
• 5. 複合免疫不全 combined immunodeficiencies

English Journal

• Type II phosphatidylinositol 4-kinases interact with FcεRIγ subunit in RBL-2H3 cells.

• Bojjireddy N1, Sinha RK, Subrahmanyam G.Author information 1Department of Biosciences and Bioengineering, Wadhwani Research Centre, Indian Institute of Technology, Bombay, Powai, Mumbai, 400076, India, naveenb@u.washington.edu.AbstractLigation of high-affinity IgE receptor I (FcεRI) on RBL-2H3 cells leads to recruitment of FcεRI and type II phosphatidylinositol 4-kinases (PtdIns 4-kinases) into lipid rafts. Lipid raft integrity is required for the activation of type II PtdIns 4-kinases and signal transduction through FcεRIγ during RBL-2H3 cell activation. However, the molecular mechanism by which PtdIns 4-kinases are coupled to FcεRI signaling is elusive. Here, we report association of type II PtdIns 4-kinase activity with FcεRIγ subunit in anti-FcεRIγ immunoprecipitates. FcεRIγ-associated PtdIns 4-kinase activity increases threefold upon FcεRI ligation in anti-FcεRIγ immunoprecipitates. Biochemical characterization of PtdIns 4-kinase activity associated with FcεRIγ reveals that it is a type II PtdIns 4-kinases. Canonical tyrosine residues mutation in FcεRIγ ITAM (Y65 and Y76) reveals that these two tyrosine residues in γ subunit are required for its interaction with type II PtdIns 4-kinases.
• Molecular and cellular biochemistry.Mol Cell Biochem.2014 May;390(1-2):197-203. doi: 10.1007/s11010-014-1970-1. Epub 2014 Feb 1.
• Ligation of high-affinity IgE receptor I (FcεRI) on RBL-2H3 cells leads to recruitment of FcεRI and type II phosphatidylinositol 4-kinases (PtdIns 4-kinases) into lipid rafts. Lipid raft integrity is required for the activation of type II PtdIns 4-kinases and signal transduction through FcεRIγ d
• PMID 24481753

• Piperine inhibits type II phosphatidylinositol 4-kinases: a key component in phosphoinositides turnover.

• Bojjireddy N1, Sinha RK, Subrahmanyam G.Author information 1Department of Biosciences and Bioengineering, Wadhwani Research Centre, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India, naveenb@u.washington.edu.AbstractPiperine has been shown to have anti-inflammatory properties. The molecular mechanisms by which it mediates anti-inflammatory activities remain elusive. Type II phosphatidylinositol 4-kinase(s) are key components in FcεRI receptor-mediated signaling leading to inflammatory mediators release in RBL-2H3 cells. The effects of piperine on IgE-mediated signaling and mast cell degranulation were investigated. Pretreatment of RBL-2H3 cells with piperine inhibited IgE-induced activation of type II PtdIns 4-kinase(s). In vitro lipid kinase assays showed piperine-inhibited type II PtdIns 4-kinase activity in a dose-dependent fashion with no effect on PtdIns 3-kinase activity. Concomitantly, pretreatment of RBL-2H3 cells with piperine also inhibited IgE-induced β-hexosaminidase release in RBL-2H3 cells. These results suggest that type II PtdIns 4-kinases are part of piperine-mediated anti-inflammatory signaling mechanisms.
• Molecular and cellular biochemistry.Mol Cell Biochem.2014 Mar 27. [Epub ahead of print]
• Piperine has been shown to have anti-inflammatory properties. The molecular mechanisms by which it mediates anti-inflammatory activities remain elusive. Type II phosphatidylinositol 4-kinase(s) are key components in FcεRI receptor-mediated signaling leading to inflammatory mediators release in RBL-
• PMID 24671493

• Biphasic regulation of type II phosphatidylinositol-4 kinase by sphingosine: cross talk between glycero- and sphingolipids in the kidney.

• Lemos T1, Verdoorn KS2, Nogaroli L1, Britto-Borges T1, Bonilha TA1, Moreno PA1, Silva OF1, Tortelote GG1, Einicker-Lamas M3.Author information 1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949-902, Ilha do Fundão, Rio de Janeiro, Brazil.2Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949-902, Ilha do Fundão, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Brazil.3Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949-902, Ilha do Fundão, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Brazil. Electronic address: einicker@biof.ufrj.br.AbstractPhosphatidylinositol-4 kinase (PI-4K) is responsible for the generation of phosphatidylinositol-4 phosphate (PtdIns(4)P), a bioactive signaling molecule involved in several biological functions. In this study, we show that sphingosine modulates the activity of the PI-4K isoform associated with the basolateral membranes (BLM) from kidney proximal tubules. Immunoblotting with an anti-α subunit PI-4K polyclonal antibody revealed the presence of two bands of 57 and 62kDa in the BLM. BLM-PI-4K activity retains noteworthy biochemical properties; it is adenosine-sensitive, not altered by wortmanin, and significantly inhibited by Ca(2+) at the μM range. Together, these observations indicate the presence of a type II PI-4K. Endogenous phosphatidylinositol (PI) alone reaches PI-4K half-maximal activity, revealing that even slight modifications in PI levels at the membrane environment promote significant variations in BLM-associated-PI-4K activity. ATP-dependence assays suggested that the Mg.ATP(2-) complex is the true substrate of the enzyme and that free Mg(2+) is an essential cofactor. Another observation indicated that higher concentrations of free ATP are inhibitory. BLM-associated-PI-4K activity was ~3-fold stimulated in the presence of increasing concentration of sphingosine, while in concentrations higher than 0.4mM, in which S1P is pronouncedly formed, there was an inhibitory effect on PtdIns(4)P formation. We propose that a tightly coupled regulatory network involving phosphoinositides and sphingolipids participate in the regulation of key physiological processes in renal BLM carried out by PI-4K.
• Biochimica et biophysica acta.Biochim Biophys Acta.2014 Mar;1838(3):1003-9. doi: 10.1016/j.bbamem.2013.12.007. Epub 2013 Dec 19.
• Phosphatidylinositol-4 kinase (PI-4K) is responsible for the generation of phosphatidylinositol-4 phosphate (PtdIns(4)P), a bioactive signaling molecule involved in several biological functions. In this study, we show that sphingosine modulates the activity of the PI-4K isoform associated with the b
• PMID 24361901

Japanese Journal

• Sphingosine-1-Phosphate Formation Activates Phosphatidylinositol-4 Kinase in Basolateral Membranes from Kidney Cells: Crosstalk in Cell Signaling through Sphingolipids and Phospholipids

• Einicker-Lamas Marcelo,Wenceslau Leandro D.,Bernardo Robson R.,Nogaroli Luciana,Guilherme Adilson,Oliveira Mecia M.,Vieyra Adalberto
• The Journal of Biochemistry 134(4), 529-536, 2003
• … Sphingosine-1-phosphate (S1P) and phosphatidylinositol-4 phosphate [PtdIns (4) P] are important second messengers in various cellular processes. … Here, we show that S1P and Ptdlns (4) P are formed in purified basolateral membranes (BLM) derived from kidney proximal tubules, indicating the presence of a plasma membrane associated SPK (BLM-SPK) and phosphatidylinositol-4 kinase (PI-4K). …
• NAID 130003534596

• Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components

• LEVINE T. P.
• Curr. Biol. 12, 695-704, 2002
• NAID 30008809665

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★リンクテーブル★

リンク元	「ホスファチジルイノシトール-4-キナーゼ」「PI 4-kinase」「phosphatidylinositol 4-kinase」「1-phosphatidylinositol 4-kinase」「PI4K」
関連記事	「PtdIns」「kinase」

「ホスファチジルイノシトール-4-キナーゼ」

　　[★]

英

phosphatidylinositol 4-kinase、PtdIns 4-kinase、PI 4-kinase、PI4K

関

1-ホスファチジルイノシトール-4-キナーゼ、ホスファチジルイノシトール4キナーゼ

「PI 4-kinase」

　　[★]

• ホスファチジルイノシトール-4-キナーゼ

関

1-phosphatidylinositol 4-kinase、phosphatidylinositol 4-kinase、PI4K、PtdIns 4-kinase

「phosphatidylinositol 4-kinase」

　　[★]

ホスファチジルイノシトール-4-キナーゼ

関

1-phosphatidylinositol 4-kinase、PI 4-kinase、PI4K、PtdIns 4-kinase

「1-phosphatidylinositol 4-kinase」

　　[★]

1-ホスファチジルイノシトール-4-キナーゼ

関

phosphatidylinositol 4-kinase、PI 4-kinase、PtdIns 4-kinase

「PI4K」

　　[★]

• ホスファチジルイノシトール-4-キナーゼ

関

phosphatidylinositol 4-kinase、PI 4-kinase、PtdIns 4-kinase

「PtdIns」

　　[★]

ホスファチジルイノシトール

• ホスファチジルイノシトール

関

inositol phospholipid、phosphatidyl inositol、phosphatidylinositol、phosphoinositide、PI

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase