phosphatidylinositol 4-kinase

ホスファチジルイノシトール-4-キナーゼ

関

1-phosphatidylinositol 4-kinase、PI 4-kinase、PI4K、PtdIns 4-kinase

WordNet

1. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
2. the basic unit of money in Papua New Guinea

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/12 05:46:49」(JST)

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1-phosphatidylinositol 4-kinase
Identifiers
EC number	2.7.1.67
CAS number	37205-54-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) is an enzyme that catalyzes the chemical reaction

ATP + 1-phosphatidyl-1D-myo-inositol ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase. Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, the structure has only been solved for this enzyme. Part of the enzyme was crystallized with its activating partner frequenin.

References

• Colodzin M, Kennedy EP (1965). "Biosynthesis of diphosphoinositide in brain". J. Biol. Chem. 240 (10): 3771–80. PMID 4284712. 
• Kai M, White GL, Hawthorne JN (1966). "The phosphatidylinositol kinase of rat brain". Biochem. J. 101 (2): 328–37. PMC 1270113. PMID 4290722. 
• Walker DH, Dougherty N, Pike LJ (1988). "Purification and characterization of a phosphatidylinositol kinase from A431 cells". Biochemistry. 27 (17): 6504–11. doi:10.1021/bi00417a046. PMID 2851325. 
• Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988). "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): 644–6. doi:10.1038/332644a0. PMID 2833705. 
• Barylko B; Gerber, SH; Binns, DD; Grichine, N; Khvotchev, M; Südhof, TC; Albanesi, JP (2001). "A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans". J. Biol. Chem. 276 (11): 7705–8. doi:10.1074/jbc.C000861200. PMID 11244087. 

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Related Links

• Phosphatidylinositol 4-kinase - Washington University

A novel phosphatidylinositol 4-kinase isolated from bovine uterus having the following characteristics: (a) molecular weight of about 55 kDa as determined by sodium dodecylsulfate polyacrylamide ... Background of the ...

• Phosphatidylinositol 4-kinases. - National Center for ...

1. Eur J Biochem. 1998 Apr 15;253(2):357-70. Phosphatidylinositol 4-kinases. Gehrmann T, Heilmeyer LM Jr. Ruhr-Universität Bochum, Institut für Physiologische Chemie, Abteilung für Biochemie Supramolekularer Systeme, Germany. ...

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★リンクテーブル★

リンク元	「ホスファチジルイノシトール-4-キナーゼ」「PI 4-kinase」「PtdIns 4-kinase」「PI4K」「ホスファチジルイノシトール4キナーゼ」
拡張検索	「1-phosphatidylinositol 4-kinase」
関連記事	「kinase」「phosphatidylinositol」

「ホスファチジルイノシトール-4-キナーゼ」

　　[★]

英

phosphatidylinositol 4-kinase、PtdIns 4-kinase、PI 4-kinase、PI4K

関

1-ホスファチジルイノシトール-4-キナーゼ、ホスファチジルイノシトール4キナーゼ

「PI 4-kinase」

　　[★]

• ホスファチジルイノシトール-4-キナーゼ

関

1-phosphatidylinositol 4-kinase、phosphatidylinositol 4-kinase、PI4K、PtdIns 4-kinase

「PtdIns 4-kinase」

　　[★]

• ホスファチジルイノシトール-4-キナーゼ

関

1-phosphatidylinositol 4-kinase、phosphatidylinositol 4-kinase、PI 4-kinase、PI4K

「PI4K」

　　[★]

• ホスファチジルイノシトール-4-キナーゼ

関

phosphatidylinositol 4-kinase、PI 4-kinase、PtdIns 4-kinase

「ホスファチジルイノシトール4キナーゼ」

　　[★]

英

phosphatidylinositol 4-kinase

関

ホスファチジルイノシトール-4-キナーゼ

「1-phosphatidylinositol 4-kinase」

　　[★]

1-ホスファチジルイノシトール-4-キナーゼ

関

phosphatidylinositol 4-kinase、PI 4-kinase、PtdIns 4-kinase

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「phosphatidylinositol」

　　[★] ホスファチジルイノシトール