パスツレラ科感染症、パスツレラ感染症
- 関
- Pasteurella infection、pasteurellosis
WordNet
- (medicine) the invasion of the body by pathogenic microorganisms and their multiplication which can lead to tissue damage and disease
- (phonetics) the alteration of a speech sound under the influence of a neighboring sound
- the pathological state resulting from the invasion of the body by pathogenic microorganisms
- (international law) illegality that taints or contaminates a ship or cargo rendering it liable to seizure
- moral corruption or contamination; "ambitious men are led astray by an infection that is almost unavoidable"
- an incident in which an infectious disease is transmitted (同)contagion, transmission
PrepTutorEJDIC
- 〈U〉(病気の)伝染;感染 / 〈C〉伝染病
UpToDate Contents
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English Journal
- Platelet-activating factor receptor blockade ameliorates Aggregatibacter actinomycetemcomitans-induced periodontal disease in mice.
- Madeira MF, Queiroz-Junior CM, Costa GM, Werneck SM, Cisalpino D, Garlet GP, Teixeira MM, Silva TA, Souza DG.Author information Department of Microbiology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.AbstractPeriodontal disease (PD) is a chronic inflammatory and alveolar bone destructive disease triggered by oral biofilm-producing microorganisms, such as Aggregatibacter actinomycetemcomitans. The levels of the phospholipid platelet-activating factor (PAF) in the saliva, gingival crevicular fluid, and periodontal tissues are significantly increased during inflammatory conditions, such as PD, but the exact mechanism that links PAF to alveolar bone resorption is not well understood. In the current study, alveolar bone resorption was induced by experimental PD through the oral inoculation of A. actinomycetemcomitans in wild-type (WT) and PAF receptor knockout (Pafr(-/-)) mice. In vitro experiments using A. actinomycetemcomitans lipopolysaccharide (LPS)-stimulated RAW 264.7 cells treated with a PAF receptor antagonist (UK74505) were also performed. The expression of lyso-PAF acetyltransferase in periodontal tissues was significantly increased 3 h after A. actinomycetemcomitans LPS injection in mice. WT and Pafr(-/-) mice that were subjected to oral inoculation of A. actinomycetemcomitans presented neutrophil accumulation and increased levels of CXCL-1 and tumor necrosis factor alpha (TNF-α) in periodontal tissues. However, Pafr(-/-) mice presented less alveolar bone loss than WT mice. The in vitro blockade of the PAF receptor impaired the resorptive activity of A. actinomycetemcomitans LPS-activated osteoclasts. In conclusion, this study shows for the first time that the blockade of PAF receptor may contribute to the progression of PD triggered by A. actinomycetemcomitans by directly affecting the differentiation and activity of osteoclasts.
- Infection and immunity.Infect Immun.2013 Nov;81(11):4244-51. doi: 10.1128/IAI.01046-13. Epub 2013 Sep 3.
- Periodontal disease (PD) is a chronic inflammatory and alveolar bone destructive disease triggered by oral biofilm-producing microorganisms, such as Aggregatibacter actinomycetemcomitans. The levels of the phospholipid platelet-activating factor (PAF) in the saliva, gingival crevicular fluid, and pe
- PMID 24002061
- Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis.
- Morey P, Viadas C, Euba B, Hood DW, Barberán M, Gil C, Grilló MJ, Bengoechea JA, Garmendia J.Author information Laboratory Microbial Pathogenesis, Fundación Investigación Sanitaria Illes Balears (FISIB), CSIC-Govern de les Illes Balears, Bunyola, Spain.AbstractNontypeable Haemophilus influenzae (NTHi) is a frequent commensal of the human nasopharynx that causes opportunistic infection in immunocompromised individuals. Existing evidence associates lipooligosaccharide (LOS) with disease, but the specific and relative contributions of NTHi LOS modifications to virulence properties of the bacterium have not been comprehensively addressed. Using NTHi strain 375, an isolate for which the detailed LOS structure has been determined, we compared systematically a set of isogenic mutant strains expressing sequentially truncated LOS. The relative contributions of 2-keto-3-deoxyoctulosonic acid, the triheptose inner core, oligosaccharide extensions on heptoses I and III, phosphorylcholine, digalactose, and sialic acid to NTHi resistance to antimicrobial peptides (AMP), self-aggregation, biofilm formation, cultured human respiratory epithelial infection, and murine pulmonary infection were assessed. We show that opsX, lgtF, lpsA, lic1, and lic2A contribute to bacterial resistance to AMP; lic1 is related to NTHi self-aggregation; lgtF, lic1, and siaB are involved in biofilm growth; opsX and lgtF participate in epithelial infection; and opsX, lgtF, and lpsA contribute to lung infection. Depending on the phenotype, the involvement of these LOS modifications occurs at different extents, independently or having an additive effect in combination. We discuss the relative contribution of LOS epitopes to NTHi virulence and frame a range of pathogenic traits in the context of infection.
- Infection and immunity.Infect Immun.2013 Nov;81(11):4100-11. doi: 10.1128/IAI.00492-13. Epub 2013 Aug 26.
- Nontypeable Haemophilus influenzae (NTHi) is a frequent commensal of the human nasopharynx that causes opportunistic infection in immunocompromised individuals. Existing evidence associates lipooligosaccharide (LOS) with disease, but the specific and relative contributions of NTHi LOS modifications
- PMID 23980106
- Identifying bacterial menu choices from the host buffet during infections.
- McLean RJ, Pringle SL.
- Journal of bacteriology.J Bacteriol.2013 Nov;195(22):4989-90. doi: 10.1128/JB.01040-13. Epub 2013 Sep 13.
- PMID 24039268
Japanese Journal
- Pasteurella pneumotropica とV因子要求性 Pasteurella 科菌のF344-rnuラットを用いた感染実験
- 林元 展人,保田 昌彦,植野 昌未,後藤 一雄,高倉 彰
- Experimental animals 57(1), 57-63, 2008-01-01
- NAID 10020177619
- Experimental Infection Studies of Pasteurella pneumotropica and V-factor Dependent Pasteurellaceae for F344-rnu Rats
- HAYASHIMOTO Nobuhito,YASUDA Masahiko,UENO Masami,GOTO Kazuo,TAKAKURA Akira
- Experimental Animals 57(1), 57-63, 2008
- … pneumotropica (Pp) and V-factor dependent Pasteurellaceae (VFDP) in immunodeficient rats, experimental infections of F344-rnu rats were performed using 3 strains (ATCC 35149, CNP 160 and RPZ) of Pp and 4 strains (V6, V7, V8 and V9) of VFDP. …
- NAID 130000068003
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- Experimental infection studies of Pasteurella pneumotropica and V-factor dependent Pasteurellaceae for F344-rnu rats. Hayashimoto N, Yasuda M, Ueno M, Goto K, Takakura A. ICLAS Monitoring Center, Central Institute for Experimental ...
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★リンクテーブル★
[★]
- 英
- Pasteurella infection、Pasteurellaceae infection
- 関
- パスツレラ症、パスツレラ感染、パスツレラ科感染症
[★]
パスツレラ感染症、パスツレラ感染
- 関
- Pasteurellaceae infection、pasteurellosis
[★]
パスツレラ症
- 関
- Pasteurella infection、Pasteurellaceae infection
[★]
- 英
- Pasteurellaceae infection
- 関
- パスツレラ感染症
[★]
- 関
- contagion、infect、infectious disease、infestation、transmission、transmit