関: PaO2、FIO2、SpO2

概念

吸入した酸素でどれだけ動脈血が酸素化されるかの指標

定義

PaO2/FIO2

PaO2=0-760 torr

FIO2=0-1

読み方

450：正常
300：呼吸不全
200：挿管、人工呼吸
100：鎮静化で人工呼吸

≦300　急性肺障害 acute lung injury ALI
≦200 ARDS acute respiratory distress syndrome

計算例

正常人：PaO2=90, FIO2=0.21　→　428
100%酸素吸入：PaO2=450, FIO2=1　→　450

PrepTutorEJDIC

protactiniumの化学記号
free in and out(船が)出入り自由の

UpToDate Contents

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1. 低酸素血症の酸素供給およびメカニズム oxygenation and mechanisms of hypoxemia
2. 急性呼吸窮迫症候群：成人における臨床的特徴および診断 acute respiratory distress syndrome clinical features and diagnosis in adults
3. 酸素毒性 oxygen toxicity
4. 動脈血液ガス arterial blood gases
5. 成人の急性呼吸窮迫症候群における機械的人工換気 mechanical ventilation of adults in acute respiratory distress syndrome

English Journal

Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China.

Zhang PJ, Li XL, Cao B, Yang SG, Liang LR, Gu L, Xu Z, Hu K, Zhang HY, Yan XX, Huang WB, Chen W, Zhang JX, Li LJ, Wang C.AbstractABSTRACT:
BMC infectious diseases.BMC Infect Dis.2012 Feb 1;12(1):29. [Epub ahead of print]
ABSTRACT:BACKGROUND: 2009 pandemic H1N1 (pH1N1) influenza posed an increased risk of severe illness among pregnant women. Data on risk factors associated with death of pregnant women and neonates with pH1N1 infections are limited outside of developed countries.METHODS: Retrospective observational st
PMID 22292815

Early use of noninvasive positive pressure ventilation for acute lung injury: A multicenter randomized controlled trial*

Zhan Q, Sun B, Liang L, Yan X, Zhang L, Yang J, Wang L, Ma Z, Shi L, Wei L, Li G, Yang L, Shi Z, Chen Y, Xu Q, Li W, Zhu X, Wang Z, Sun Y, Zhuo J, Liu Y, Li X, Wang C.SourceFrom the Collaborative Research Group of Noninvasive Mechanical Ventilation for ALI/ARDS, including the following members: Department of Respiratory and Critical Care Medicine (QZ, BS, LL), Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University; the Pulmonary Department (XY, LZ), The Second Hospital Affiliated Hebei Medical University; the Department of Pulmonary and Critical Care Medicine (JY, LW), The Third Affiliated Hospital of Inner Mongolia Medical College; the Pulmonary Department (ZM, LS), The Shenyang Military Region General Hospital; the Pulmonary Department (LW, GL), The People's Armed Police Corps General Hospital of Tianjin; the Pulmonary Department (LY, ZS), The First Affiliated Hospital of Medical College, Xian Jiaotong University; the Pulmonary Department (YC, QX, WL), The Affiliated Hospital of Bengbu Medical College; the Department of Critical Care Medicine (XZ, ZW), The Third Hospital of Peking University; the Pulmonary Department (YS, JZ), Beijing Tongren Hospital; Department of Critical Care Medicine (YL, XL), Hebei Tangshan Gongren Hospital; and the Beijing Institute of Respiratory Medicine (CW), Beijing Hospital, Ministry of Health, Beijing, China.
Critical care medicine.Crit Care Med.2012 Feb;40(2):455-460.
OBJECTIVE: Noninvasive positive pressure ventilation is beneficial for patients with acute respiratory failure. However, its possible benefit for patients with acute lung injury (200 mm Hg < PaO2/FIO2 ≤300 mm Hg) remains unclear. Our aim was to assess the safety and efficacy of noninvasive posi
PMID 22020236

Combined Recombinant Human Activated Protein C and Ceftazidime Prevent the Onset of Acute Respiratory Distress Syndrome in Severe Sepsis.

Maybauer MO, Maybauer DM, Fraser JF, Westphal M, Szabó C, Cox RA, Hawkins HK, Traber LD, Traber DL.Source*Department of Anesthesiology, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas; †Department of Anaesthesiology and Intensive Care Medicine, Philipps University of Marburg, Marburg, Germany; ‡Critical Care Research Group, University of Queensland and The Prince Charles Hospital at Brisbane, Chermside, Queensland, Australia; and §Department of Pathology, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas.
Shock (Augusta, Ga.).Shock.2012 Feb;37(2):170-176.
ABSTRACT: This experimental animal study investigates the effects of combined recombinant human activated protein C (rhAPC) and ceftazidime on cardiopulmonary function in acute lung injury and severe sepsis. Twenty-one sheep (37 ± 2 kg) were operatively prepared and randomly allocated to either the
PMID 22089200

Japanese Journal

Comparison of extracellular-type-kyoto solution and perfadex as a preservation solution in a pig ex vivo lung perfusion model: impact of potassium level.

Okamoto T,Chen F,Zhang J,Choi H,Yamada T,Morikawa H,Nakayama E,Bando T,Date H
Transplantation proceedings 43(5), 1525-1528, 2011-06
… Results：In both groups, perfusion for 2 hours showed no differences between the 2 groups with respect to the final flow, pulmonary arterial pressure, pulmonary vascular resistance, PaO2/FiO2, and shunt fraction. …
NAID 120003238948

The Effect of Sivelestat Sodium Hydrate on Severe Respiratory Failure after Thoracic Aortic Surgery with Deep Hypothermia

Morimoto Keisuke,Nishimura Kengo,Miyasaka Shigeto,Maeta Hiroyuki,Taniguchi Iwao
Annals of Thoracic and Cardiovascular Surgery advpub(0), 1107050015, 2011
… Of these patients, 22 had postoperative respiratory failure with PaO2/FiO2 ratios of less than 150. …
NAID 130000728025