- 関
- PAX3, FKHR, rhabdomyosarcoma
WordNet
- a highly malignant neoplasm derived from striated muscle (同)rhabdosarcoma
- a nuclear reaction in which nuclei combine to form more massive nuclei with the simultaneous release of energy (同)nuclear_fusion, nuclear fusion reaction
- the merging of adjacent sounds or syllables or words
- correction of an unstable part of the spine by joining two or more vertebrae; usually done surgically but sometimes done by traction or immobilization (同)spinal_fusion
- the act of fusing (or melting) together
- an occurrence that involves the production of a union (同)merger, unification
- the combining of images from the two eyes to form a single visual percept (同)optical fusion
- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
- informal term for information; "give me the gen on your new line of computers"
PrepTutorEJDIC
- 〈U〉(金属などが)溶けること,融解,融合《+『of』+『名』》 / 〈C〉融合物 / 〈C〉(政党・党派などの)連合,合同;(民族などの)融合《+『of』+『名』》 / 〈U〉〈C〉核融合(nuclear fusion)
- 遺伝子
- personal assistant個人秘書 / public address [system]
UpToDate Contents
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- 1. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
English Journal
- Alternate PAX3 and PAX7 C-terminal isoforms in myogenic differentiation and sarcomagenesis.
- Charytonowicz E1, Matushansky I, Castillo-Martin M, Hricik T, Cordon-Cardo C, Ziman M.
- Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.Clin Transl Oncol.2011 Mar;13(3):194-203. doi: 10.1007/s12094-011-0640-y.
- OBJECTIVE: Pax3 and Pax7 are closely related genes that are involved in commitment of cells to a myogenic lineage during skeletal muscle development and regeneration. Several Pax3 and Pax7 transcripts are expressed from the genes, generating different isoforms with potentially distinct DNA binding a
- PMID 21421465
- Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma.
- Oesch S1, Walter D, Wachtel M, Pretre K, Salazar M, Guzmán M, Velasco G, Schäfer BW.
- Molecular cancer therapeutics.Mol Cancer Ther.2009 Jul;8(7):1838-45. doi: 10.1158/1535-7163.MCT-08-1147. Epub 2009 Jun 9.
- Gene expression profiling has revealed that the gene coding for cannabinoid receptor 1 (CB1) is highly up-regulated in rhabdomyosarcoma biopsies bearing the typical chromosomal translocations PAX3/FKHR or PAX7/FKHR. Because cannabinoid receptor agonists are capable of reducing proliferation and indu
- PMID 19509271
- Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors.
- Makawita S1, Ho M, Durbin AD, Thorner PS, Malkin D, Somers GR.
- Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.Pediatr Dev Pathol.2009 Mar-Apr;12(2):127-35. doi: 10.2350/08-05-0477.1. Epub 2008 Sep 12.
- Recent studies have shown a significant involvement of insulin-like growth factor (IGF) signaling components in the pathogenesis of rhabdomyosarcoma (RMS). Furthermore, there has been some evidence to indicate that differential expression of IGF pathway genes can distinguish RMS subtypes. The presen
- PMID 18788888
Japanese Journal
- Alveolar Rhabdomyosarcoma Mimicking Nasal Lymphoma at The Initial Presentation
- IHARA Tatsuya,OKAMURA Daisuke,TAKAHASHI Naoki,KOHRI Mika,KAYANO Hidekazu,TAMARU Jun-ichi,NIITSU Nozomi
- Journal of clinical and experimental hematopathology 48(2), 61-64, 2008-11-01
- … The patient was positive for the <I>PAX3-FKHR</I> … fusion gene. …
- NAID 10023917300
- Adult cutaneous alveolar rhabdomyosarcoma on the face diagnosed by the expression of PAX3-FKHR gene fusion transcripts
- NAKAGAWA Noboru,TSUDA Tatsuya,YAMAMOTO Mika,ITO Takaaki,FUTANI Hiroshi,YAMANISHI Kiyofumi
- Journal of dermatology 35(7), 462-467, 2008-07-01
- NAID 10024297532
Related Links
- PAX3-FOXO1 (formerly known as PAX3-FKHR) was cloned in 1993, after identification and further characterization of the t(2;13)(q35;q14) translocation, and also proven to generate the predicted fusion protein[5;6]. As with other fusion ...
- ... on its expression pattern in well-established tumor samples. Thus, we have taken the first step towards characterizing FKHR-PAX3 fusion gene products and their potential role in oncogenic transformation and tumorogenesis ...
★リンクテーブル★
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- 微生物学:粒子凝集法(particle agglutination test)
- 薬理学:
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- 関
- fused gene