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1. 薬理ゲノム学の概要 overview of pharmacogenomics
2. 直接トロンビン阻害剤および直接Xa因子阻害剤による抗凝固療法 anticoagulation with direct thrombin inhibitors and direct factor xa inhibitors
3. 2型糖尿病の治療のためのジペプチジルペプチダーゼ4（DPP-4）阻害剤 dipeptidyl peptidase 4 dpp 4 inhibitors for the treatment of type 2 diabetes mellitus
4. 急性痛風の治療 treatment of acute gout
5. 薬と肝臓：代謝および肝障害の機序 drugs and the liver metabolism and mechanisms of injury

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.

Hendrikx JJ, Lagas JS, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.SourceDepartment of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Jeroen.Hendrikx@slz.nl.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 May 15;132(10):2439-47. doi: 10.1002/ijc.27912. Epub 2012 Nov 14.
Paclitaxel is avidly transported by P-glycoprotein (P-gp/MDR1/ABCB1). This results in low oral bioavailability, which can be boosted by coadministration of P-gp inhibitors. Unlike paclitaxel, docetaxel is extensively metabolized by CYP3A4 and its oral bioavailability can be enhanced in mice and huma
PMID 23090875

P-glycoprotein (PGP) Polymorphisms and Sexual Dysfunction in Female Patients With Depression and SSRI-Associated Sexual Side Effects.

Bly MJ, Bishop JR, Thomas KL, Ellingrod VL.Sourcea College of Pharmacy , University of Michigan , Ann Arbor , Michigan , USA.
Journal of sex & marital therapy.J Sex Marital Ther.2013 May;39(3):280-8. doi: 10.1080/0092623X.2011.615896. Epub 2013 Jan 28.
Sexual dysfunction is common with selective serotonin reuptake inhibitor use for major depressive disorder. Studies have shown associations between genetic variation in the adenosine triphosphate (ATP)-binding cassette, subfamily B, member 1 gene (ABCB1), which encodes the drug efflux transporter P-
PMID 23356581

Interaction between electrical modulation of the brain and pharmacotherapy to control pharmacoresistant epilepsy.

Rocha L.SourcePharmacobiology Department, Center for Research and Advanced Studies, Calz. Tenorios 235, Col. Granjas Coapa, Mexico City 14330, Mexico. Electronic address: lrocha@cinvestav.mx.
Pharmacology & therapeutics.Pharmacol Ther.2013 May;138(2):211-28. doi: 10.1016/j.pharmthera.2013.01.009. Epub 2013 Jan 24.
In spite of the high success rate of many surgical procedures for pharmacoresistant epilepsy, a substantial number of patients do not become seizure-free. Different strategies for electrical modulation of the brain such as Deep Brain Stimulation, Vagal Nerve Stimulation and Transcraneal Magnetic Sti
PMID 23353099

Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5

Arakawa Hiroshi,Shirasaka Yoshiyuki,Haga Makoto,Nakanishi Takeo,Tamai Ikumi
Biopharmaceutics and Drug Disposition 33(6), 332-341, 2012-09
… The disappeared and absorbed amount of ciprofloxacin from the intestinal lumen were increased markedly in the presence of 7,8-benzoflavone, a breast cancer resistance protein inhibitor, and ivermectin, a P-glycoprotein inhibitor, while it was decreased significantly in the presence of these inhibitors in combination with naringin, an Oatp1a5 inhibitor. …
NAID 120004997009

Lack of Contribution of P-Glycoprotein-Mediated Transport to Renal Excretion of Pilsicainide in Humans

SHIGA Tsuyoshi,HASHIGUCHI Masayuki,TANAKA Takanori,MOROZUMI Naomi,IRIE Shin,MOCHIZUKI Mayumi,HAGIWARA Nobuhisa,KASANUKI Hiroshi
臨床薬理 = Japanese journal of clinical pharmacology 43(3), 157-164, 2012-05-31
NAID 10030763575