関: L-NMMA、omega-N-methylarginine

WordNet

the 12th letter of the Roman alphabet (同)l
the 14th letter of the Roman alphabet (同)n
a bitter tasting amino acid found in proteins and necessary for nutrition; its absence from the diet leads to a reduced production of spermatozoa

PrepTutorEJDIC

lira(イタリアの貨幣単位リラ)
nitrogenの化学記号
liter[s]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/21 17:04:25」(JST)

wiki en

N-Methylarginine is an inhibitor of nitric oxide synthase.^[1]^[2] Chemically, it is a methyl derivative of the amino acid arginine. It is used as a biochemical tool in the study of physiological role of nitric oxide.

The inhibiting effect of N-methylarginine on vasodilation is lower in hypertensive patients than in normal subjects, indicating endothelial dysfunction.^[3] The inhibiting effect of N-methylarginine on vasodilation declines progressively with age, but has been restored with vitamin C (except in the oldest subjects).^[3]

References

^ Toutouzas, K.; Riga, M.; Stefanadi, E.; Stefanadis, C. (2008). "Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance". Hormone and Metabolic Research 40 (9): 655–659. doi:10.1055/s-0028-1083814. PMID 18792879.
^ Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH (1994). "N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats". Arthritis & Rheumatology 37 (7): 1062–1069. PMID 7517676.
^ ^a ^b Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A (2012). "Age-related reduction of NO availability and oxidative stress in human". Hypertension 38 (2): 274–279. PMID 11509489.

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English Journal

Cystathionine-β-Synthase Gene Transfer Into Rostral Ventrolateral Medulla Exacerbates Hypertension via Nitric Oxide in Spontaneously Hypertensive Rats.

Duan XC1, Liu SY2, Guo R3, Xiao L2, Xue HM2, Guo Q2, Jin S2, Wu YM4.
American journal of hypertension.Am J Hypertens.2015 Sep;28(9):1106-13. doi: 10.1093/ajh/hpu299. Epub 2015 Jan 26.
BACKGROUND: Rostral ventrolateral medulla (RVLM) plays a crucial role in the central regulation of cardiovascular functions. Cystathionine-β-synthase (CBS) is a major hydrogen sulfide (H2S)-generating enzyme that has been identified mainly in the brain. The present study was designed to examine CBS
PMID 25628417

Nitric Oxide Inhibitors Hit Target for Triple-Negative Breast Cancer.

Firger J.
Journal of the National Cancer Institute.J Natl Cancer Inst.2015 Aug 4;107(8). pii: djv235. doi: 10.1093/jnci/djv235. Print 2015 Aug.
PMID 26243205

Exaggerated Exercise Blood Pressure Response and Future Cardiovascular Disease.

Tzemos N1, Lim PO2, Mackenzie IS2, MacDonald TM2.
Journal of clinical hypertension (Greenwich, Conn.).J Clin Hypertens (Greenwich).2015 Aug 3. doi: 10.1111/jch.12629. [Epub ahead of print]
Exaggerated blood pressure (BP) response to exercise predicts future hypertension. However, there is considerable lack of understanding regarding the mechanism of how this abnormal response is generated, and how it relates to the future establishment of cardiovascular disease. The authors studied 82
PMID 26235814

Japanese Journal

Reduction of Nitric Oxide-Mediated γ-Amino Butyric Acid Release in Rostral Ventrolateral Medulla Is Involved in Superoxide-Induced Sympathoexcitation of Hypertensive Rats

SHINOHARA Keisuke,HIROOKA Yoshitaka,KISHI Takuya,SUNAGAWA Kenji
Circulation journal : official journal of the Japanese Circulation Society 76(12), 2814-2821, 2012-11-25
… Microinjection of NG-monomethyl-L-arginine (L-NMMA), an NO synthase inhibitor, into the RVLM increased AP, HR, and RSNA with a decrease in GABA release in the RVLM. … Prior microinjection of L-NMMA into the RVLM attenuated the tempol-induced changes in AP, HR, RSNA, and GABA release in the RVLM. …
NAID 10031126053

Inhibition of L-Arginine Metabolizing Enzymes by L-Arginine-Derived Advanced Glycation End Products

Lai Ying-Ling,Aoyama Sae,Nagai Ryoji,Miyoshi Noriyuki,Ohshima Hiroshi
Journal of Clinical Biochemistry and Nutrition 46(2), 177-185, 2010
… Nω-Carboxymethyl-arginine (CMA), Nω-carboxyethyl-arginine (CEA) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) have been identified as L-arginine-derived advanced glycation end products (AGEs) formed by non-enzymatic reactions between reducing sugars such as glucose and amino groups in proteins. …
NAID 130004466608

Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease

Higashi Yukihito,Goto Chikara,Hidaka Takayuki,Soga Junko,Nakamura Shuji,Fujii Yuichi,Hata Takaki,Idei Naomi,Fujimura Noritaka,Chayama Kazuaki,Kihara Yasuki,Taguchi Akira
Atheroscierosis 206(2), 604-610, 2009-10
… Periodontal therapy reduced serum concentrations of C-reactive protein from 2.7 +/- 1.9 to 1.8 +/- 0.9 mg/L (P < … 0.05) and interleukin-6 from 2.6 +/- 3.4 to 1.6 +/- 2.6 ng/L (P < … After administration of NG-monomethyl-l-arginine, a nitric oxide synthase inhibitor, FBF response to ACh was similar before and after treatment. …
NAID 120001898374

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★リンクテーブル★

リンク元	「L-NMMA」「omega-N-methylarginine」
関連記事	「L」「N」「NG」「ng」

「L-NMMA」

Methylarginine
	; (S)-Methylarginine
Names
	Other names 2-Amino-5-[(N’-methylcarbamimidoyl)amino]pentanoic acid; N-Monomethylarginine; omega-N-Methylarginine
Identifiers
Beilstein Reference	2262067 (R)
CAS Registry Number	17035-90-4 (S)
ChEBI	CHEBI:28229
ChEMBL	ChEMBL312870 ; ChEMBL109350 ; ChEMBL256147
ChemSpider	4213 ; 2015298 (R) ; 117259 (S)
	InChI InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11) ; Key: NTNWOCRCBQPEKQ-UHFFFAOYSA-N ;
Jmol-3D images	Image; Image
KEGG	C03884
MeSH	omega-N-Methylarginine
PubChem	4366; 2733510 (R); 132862 (S)
	SMILES C[nH]:c(:[nH]):[nH]CCCC(N)c(:[o]):[oH] ; CNC(=N)NCCCC(N)C(O)=O ;
Properties
Molecular formula	C7H16N4O2
Molar mass	188.23 g·mol−1
log P	−0.63
Acidity (pKa)	2.512
Basicity (pKb)	11.488
Related compounds
Related alkanoic acids	Asymmetric dimethylarginine; N-Propyl-L-arginine;
Related compounds	Buformin; Acecarbromal;
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	verify (what is: /?)
	Infobox references

　　[★]

NG-モノメチル-L-アルギニン

関: NG-monomethyl-L-arginine、omega-N-methylarginine

「omega-N-methylarginine」

　　[★]

ω-N-メチルアルギニン

関: L-NMMA、NG-monomethyl-L-arginine

「L」

　　[★]

「N」

　　[★]

アスパラギン asparagine
窒素(原子、分子)

「NG」

　　[★] 腫瘍。新生物 new growth

「ng」

　　[★]

ナノグラム

関: nanogram

[1] Toutouzas, K.; Riga, M.; Stefanadi, E.; Stefanadis, C. (2008). "Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance". Hormone and Metabolic Research 40 (9): 655–659. doi:10.1055/s-0028-1083814. PMID 18792879.

[pmid7517676-2] Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH (1994). "N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats". Arthritis & Rheumatology 37 (7): 1062–1069. PMID 7517676.

[pmid11509489-3] Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A (2012). "Age-related reduction of NO availability and oxidative stress in human". Hypertension 38 (2): 274–279. PMID 11509489.

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案内

案内

NG-monomethyl-L-arginine