関: NG-monomethyl-L-arginine、omega-N-methylarginine

WordNet

the 12th letter of the Roman alphabet (同)l

PrepTutorEJDIC

lira(イタリアの貨幣単位リラ)
liter[s]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/12 01:29:22」(JST)

wiki en

N-Methylarginine is an inhibitor of nitric oxide synthase.^[1]^[2] Chemically, it is a methyl derivative of the amino acid arginine. It is used as a biochemical tool in the study of physiological role of nitric oxide.

The inhibiting effect of N-methylarginine on vasodilation is lower in hypertensive patients than in normal subjects, indicating endothelial dysfunction.^[3] The inhibiting effect of N-methylarginine on vasodilation declines progressively with age, but has been restored with vitamin C (except in the oldest subjects).^[3]

References

^ Toutouzas, K.; Riga, M.; Stefanadi, E.; Stefanadis, C. (2008). "Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance". Hormone and Metabolic Research. 40 (9): 655–659. doi:10.1055/s-0028-1083814. PMID 18792879.
^ Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH (1994). "N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats". Arthritis & Rheumatology. 37 (7): 1062–1069. PMID 7517676.
^ ^a ^b Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A (2012). "Age-related reduction of NO availability and oxidative stress in human". Hypertension. 38 (2): 274–279. PMID 11509489.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 昇圧剤および強心剤の使用 use of vasopressors and inotropes
2. 急性心筋梗塞を合併する心原性ショックの予後および治療 prognosis and treatment of cardiogenic shock complicating acute myocardial infarction
3. 成人における緊張型頭痛：病態生理、臨床的特徴、および診断 tension type headache in adults pathophysiology clinical features and diagnosis
4. 一酸化窒素と腎臓 nitric oxide and the kidney
5. 中毒性巨大結腸症 toxic megacolon

English Journal

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species.

Gage MC, Yuldasheva NY, Viswambharan H, Sukumar P, Cubbon RM, Galloway S, Imrie H, Skromna A, Smith J, Jackson CL, Kearney MT, Wheatcroft SB.SourceDivision of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, United Kingdom.
Atherosclerosis.Atherosclerosis.2013 Sep;230(1):131-9. doi: 10.1016/j.atherosclerosis.2013.06.017. Epub 2013 Jun 29.
OBJECTIVE: Systemic insulin resistance is associated with a portfolio of risk factors for atherosclerosis development. We sought to determine whether insulin resistance specifically at the level of the endothelium promotes atherosclerosis and to examine the potential involvement of reactive oxygen s
PMID 23958265

Activation of RAW264.7 mouse macrophage cells in vitro through treatment with recombinant ricin toxin-binding subunit B: Involvement of protein tyrosine, NF-κB and JAK-STAT kinase signaling pathways.

Xu N, Yuan H, Liu W, Li S, Liu Y, Wan J, Li X, Zhang R, Chang Y.SourceDepartment of Immunology, Norman Bethune College of Medical Science, Jilin University, Jilin, P.R. China.
International journal of molecular medicine.Int J Mol Med.2013 Sep;32(3):729-35. doi: 10.3892/ijmm.2013.1426. Epub 2013 Jul 2.
Ricin toxin-binding subunit B (RTB) is a galactose-binding lectin protein. In the present study, we investigated the effects of RTB on inducible nitric oxide (NO) synthase (iNOS), interleukin (IL)-6 and tumor necrosis factor (TNF)-α, as well as the signal transduction mechanisms involved in recombi
PMID 23820591

Administration of telmisartan reduced systolic blood pressure and oxidative stress probably through the activation of PI3K/Akt/eNOS pathway and NO release in spontaneously hypertensive rats.

Xu L, Liu Y.SourceSecond Department of Cardiology, Tianjin Chest Hospital, Tianjin, China. wmccp2008@126.com.
Physiological research / Academia Scientiarum Bohemoslovaca.Physiol Res.2013 Aug 21;62(4):351-9. Epub 2013 Apr 16.
We investigated the effects of telmisartan, the blocker of angiotensin II receptor 1, on the regulation of systolic blood pressure (SBP) and oxidative stress through endothelial nitric oxide (NO) release in spontaneously hypertensive rats (SHRs). SHRs randomly received placebo, oral feeding of telmi
PMID 23590610

Japanese Journal

Promotion of Endothelial Wound Healing by the Chalcones 4-hydroxyderricin and Xanthoangelol, and the Molecular Mechanism of This Effect

Journal of Developments in Sustainable Agriculture 12(1), 25-33, 2017
NAID 130005681163

ビスフェノールＡによるニトロシル化を介した脳神経系への影響解析

日本毒性学会学術年会 43.1(0), O-51, 2016
NAID 130005260646

Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor

Acta Medica Okayama 69(5), 279-290, 2015-10
NAID 120005666066

Related Pictures

★リンクテーブル★

リンク元	「NG-monomethyl-L-arginine」「omega-N-methylarginine」
関連記事	「L」「NM」

「NG-monomethyl-L-arginine」

Methylarginine
	; (S)-Methylarginine
Names
	Other names 2-Amino-5-[(N’-methylcarbamimidoyl)amino]pentanoic acid; N-Monomethylarginine; omega-N-Methylarginine
Identifiers
CAS Number	17035-90-4 (S)
Beilstein Reference	2262067 (R)
ChEBI	CHEBI:28229
ChEMBL	ChEMBL312870 ; ChEMBL109350 ; ChEMBL256147
ChemSpider	4213 ; 2015298 (R) ; 117259 (S)
Jmol 3D model	Interactive image; Interactive image
KEGG	C03884
MeSH	omega-N-Methylarginine
PubChem	4366; 2733510 (R); 132862 (S)
	InChI InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11) Key: NTNWOCRCBQPEKQ-UHFFFAOYSA-N ;
	SMILES C[nH]:c(:[nH]):[nH]CCCC(N)c(:[o]):[oH] ; CNC(=N)NCCCC(N)C(O)=O ;
Properties
Chemical formula	C7H16N4O2
Molar mass	188.23 g·mol−1
log P	−0.63
Acidity (pKa)	2.512
Basicity (pKb)	11.488
Related compounds
Related alkanoic acids	Asymmetric dimethylarginine; N-Propyl-L-arginine;
Related compounds	Buformin; Acecarbromal;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

NG-モノメチル-L-アルギニン

関: L-NMMA、omega-N-methylarginine

「omega-N-methylarginine」

　　[★]

ω-N-メチルアルギニン

関: L-NMMA、NG-monomethyl-L-arginine

「L」

　　[★]

「NM」

　　[★]

[1] Toutouzas, K.; Riga, M.; Stefanadi, E.; Stefanadis, C. (2008). "Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance". Hormone and Metabolic Research. 40 (9): 655–659. doi:10.1055/s-0028-1083814. PMID 18792879.

[pmid7517676-2] Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH (1994). "N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats". Arthritis & Rheumatology. 37 (7): 1062–1069. PMID 7517676.

[pmid11509489-3] Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A (2012). "Age-related reduction of NO availability and oxidative stress in human". Hypertension. 38 (2): 274–279. PMID 11509489.

匿名

検索

案内

案内

L-NMMA