NADPHジアホラーゼ、NADPHジアフォラーゼ
- 関
- NADPH dehydrogenase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/08 03:30:20」(JST)
[Wiki en表示]
NADPH dehydrogenase |
X-ray structure of Xenobiotic Reductase A from Pseudomonas putida. PDB entry 3l5l
|
Identifiers |
EC number |
1.6.99.1 |
CAS number |
9001-68-7 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
In enzymology, a NADPH dehydrogenase (EC 1.6.99.1) is an enzyme that catalyzes the chemical reaction
- NADPH + H+ + acceptor NADP+ + reduced acceptor
The 3 substrates of this enzyme are NADPH, H+, and acceptor, whereas its two products are NADP+ and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADPH:acceptor oxidoreductase. Other names in common use include NADPH2 diaphorase, NADPH diaphorase, OYE, diaphorase, dihydronicotinamide adenine dinucleotide phosphate dehydrogenase, NADPH-dehydrogenase, NADPH-diaphorase, NADPH2-dehydrogenase, old yellow enzyme, reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, TPNH dehydrogenase, TPNH-diaphorase, triphosphopyridine diaphorase, triphosphopyridine nucleotide diaphorase, NADPH2 dehydrogenase, and NADPH:(acceptor) oxidoreductase. It has 2 cofactors: FAD, and FMN.
References
- Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 477-494.
- AVRON M, JAGENDORF AT (1957). "Some further investigations on chloroplast TPNH diaphorase". Arch. Biochem. Biophys. 72 (1): 17–24. doi:10.1016/0003-9861(57)90169-8. PMID 13471057.
- Jagendorf AT (1963). "Chloroplast TPNH diaphorase". Methods Enzymol. 6: 430–434.
- Theorell H (1935). "Das gelbe Oxydationsferment". Biochem. Z. 278: 263–290.
- Theorell H and Akesson A (1956). "Molecular weight and FMN content of crystalline "old yellow enzyme"". Arch. Biochem. Biophys. 65 (1): 439–448. doi:10.1016/0003-9861(56)90204-1. PMID 13373435.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Anagliptin protects neuronal cells against endogenous amyloid β (Aβ)-induced cytotoxicity and apoptosis.
- Chen Z, Tao S, Li X, Zeng X, Zhang M, Yao Q.
- Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)2213-2220.
- Excessive generation and accumulation of amyloid-β (Aβ) fragments by familial mutations of amyloid precursor protein (APP) and presenilin 1 (PS1) play a key role in causing oxidative stress, mitochondrial abnormalities and neuronal apoptosis in Alzheimer's disease (AD). Anagliptin, a novel DPP-4 i
- PMID 31159590
- Orexin A ameliorates HBV X protein-induced cytotoxicity and inflammatory response in human hepatocytes.
- Wang L, He T, Wan B, Wang X, Zhang L.
- Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)2003-2009.
- Hepatitis B virus is one of the main causes of hepatitis and hepatocellular carcinoma (HCC). Hepatitis B virus-encoded X protein (HBx) has been shown to be involved in many aspects of the pathogenicity of liver diseases. Orexin A is a small peptide produced in the hippocampus. Orexin A and its recep
- PMID 31106596
- Vascular protection of salicin on IL-1β-induced endothelial inflammatory response and damages in retinal endothelial cells.
- Song Y, Tian X, Wang X, Feng H.
- Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1995-2002.
- Retinal endothelial cells (RECs) are involved in many ocular diseases such as age-related macular degeneration (AMD) and diabetic retinopathy. Salicin is the major ingredient of willow bark extract, and it has been shown to be a potent anti-inflammatory agent. We aim to explore whether salicin has a
- PMID 31106593
Japanese Journal
- Localization of eNOS in the Olfactory Epithelium of the Rat
- ENDO Daisuke,YAMAMOTO Yoshio,YAMAGUCHI-YAMADA Misuzu,NAKAMUTA Nobuaki,TANIGUCHI Kazuyuki
- Journal of Veterinary Medical Science advpub(0), 1010280379, 2010
- … The activity of NADPH-diaphorase was also examined as a marker of NOS. In the dorsomedial region of the nasal cavity, intensely positive reactions for NADPH-diaphorase were observed in the entire cytoplasm of sensory cells (olfactory cells). …
- NAID 130000444379
- Nitric oxide-cGMP signaling regulates axonal elongation during optic nerve regeneration in the goldfish in vitro and in vivo
- Koriyama Yoshiki,Yasuda Rie,Homma Keiko,Mawatari Kazuhiro,Nagashima Mikiko,Sugitani Kayo,Matsukawa Toru,Kato Satoru
- Journal of Neurochemistry 110(3), 890-901, 2009-08
- … NADPH diaphorase staining revealed that nitric oxide synthase (NOS) activity was up-regulated primarily in the retinal ganglion cells (RGCs) 5-40 days after axotomy. …
- NAID 120001450994
Related Links
- I.U.B.: 1.6.99.1 C.A.S.: 9001-68-7 NADPH: (acceptor) oxidoreductase Enzymatic Reaction (image will open in a new window) The diaphorases are a ubiquitous class of flavin-bound enzymes that catalyze the reduction of various dyes ...
- Proc. Natl. Acad. Sci. USA88(1991) 2813 with0.5MNaCl.SomeNADPHdiaphoraseactivitydidelute inthesaltwash;however,thisactivitywasnotrecognizedby the NADPH diaphorase-specific antibody and, therefore, does not correspond to ...
★リンクテーブル★
[★]
- 英
- NADPH diaphorase
- 関
- NADPHデヒドロゲナーゼ、NADPHジアホラーゼ
[★]
NADPH脱水素酵素、NADPHデヒドロゲナーゼ
- 関
- NADPH diaphorase
[★]
- 英
- NADPH diaphorase
- 関
- NADPHジアフォラーゼ
[★]
- 関
- nicotinamide adenine dinucleotide phosphate
- グルタチオンの還元に必要。
- 足らなくなると、フリーラジカルや過酸化物を無毒化できなくなる。
- 赤血球の場合でNADPHが足らないと、fava beans, sulfonamides, primaquineおよび抗結核薬などの酸化剤によって溶血性貧血を起こす。
[★]
[★]
ニコチンアミドアデニンジヌクレオチドリン酸 nicotinamide adenine dinucleotide phosphate
[★]
ジアホラーゼ、ジアフォラーゼ
- 関
- dihydrolipoamide dehydrogenase