N-acetylmuramoyl-L-alanine amidase

N-アセチルムラモイル-L-アラニンアミダーゼ

関

autolysin

WordNet

1. the 12th letter of the Roman alphabet (同)l
2. the 14th letter of the Roman alphabet (同)n
3. a crystalline amino acid that occurs in many proteins

PrepTutorEJDIC

1. lira(イタリアの貨幣単位リラ)
2. nitrogenの化学記号
3. neodymiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/29 10:01:14」(JST)

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[Wiki en表示]

N-acetylmuramoyl-L-alanine amidase
Identifiers
EC number	3.5.1.28
CAS number	9013-25-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Amidase_2
crystal structure of the c-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein ialpha
Identifiers
Symbol	Amidase_2
Pfam	PF01510
InterPro	IPR002502
SCOP	1lba
SUPERFAMILY	1lba
OPM superfamily	438
OPM protein	1sk4
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Amidase_3
structure of the catalytic domain of cwlv, n-acetylmuramoyl-l-alanine amidase from bacillus(paenibacillus) polymyxa var.colistinus
Identifiers
Symbol	Amidase_3
Pfam	PF01520
Pfam clan	CL0035
InterPro	IPR002508
SCOP	1jwq
SUPERFAMILY	1jwq
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Amidase_5
Identifiers
Symbol	Amidase_5
Pfam	PF05382
Pfam clan	CL0125
InterPro	IPR008044
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Amidase02_C
Identifiers
Symbol	Amidase02_C
Pfam	PF12123
InterPro	IPR021976
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In enzymology, a N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) is an enzyme that catalyzes a chemical reaction that cleaves the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-nitrogen bonds other than peptide bonds in linear amides. The systematic name of this enzyme class is peptidoglycan amidohydrolase. Other names in common use include acetylmuramyl-L-alanine amidase, N-acetylmuramyl-L-alanine amidase, N-acylmuramyl-L-alanine amidase, acetylmuramoyl-alanine amidase, N-acetylmuramic acid L-alanine amidase, acetylmuramyl-alanine amidase, N-acetylmuramylalanine amidase, N-acetylmuramoyl-L-alanine amidase type I, and N-acetylmuramoyl-L-alanine amidase type II. This enzyme participates in peptidoglycan biosynthesis. Autolysins and some phage lysins are examples of N-acetylmuramoyl-L-alanine amidases.

See also

• Phage lysins
• Autolysins
• PGLYRP2

References

• Campbell JN; Dierickx, L; Coyette, J; Leyh-Bouille, M; Guinand, M; Campbell, JN (1969). "An improved technique for the preparation of Streptomyces peptidases and N-acetylmuramyl-l-alanine amidase active on bacterial wall peptidoglycans". Biochemistry. 8 (1): 213–22. doi:10.1021/bi00829a031. PMID 5777325. 
• Herbold DR, Glaser L (1975). "Interaction of N-acetylmuramic acid L-alanine amidase with cell wall polymers". J. Biol. Chem. 250 (18): 7231–8. PMID 809432. 
• Herbold DR, Glaser L (1975). "Bacillus subtilis N-acetylmuramic acid L-alanine amidase". J. Biol. Chem. 250 (5): 1676–82. PMID 803507. 
• Ward JB, Curtis CA, Taylor C, Buxton RS (1982). "Purification and characterization of two phage PBSX-induced lytic enzymes of Bacillus subtilis 168: an N-acetylmuramoyl-L-alanine amidase and an N-acetylmuramidase". J. Gen. Microbiol. 128 (6): 1171–8. doi:10.1099/00221287-128-6-1171. PMID 6126517. 

UpToDate Contents

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English Journal

• Structure-based modification of a Clostridium difficile-targeting endolysin affects activity and host range.

• Mayer MJ, Garefalaki V, Spoerl R, Narbad A, Meijers R.SourceInstitute of Food Research, Colney, Norwich NR4 7UA, United Kingdom. Melinda.Mayer@BBSRC.ac.uk
• Journal of bacteriology.J Bacteriol.2011 Oct;193(19):5477-86. Epub 2011 Jul 29.
• Endolysin CD27L causes cell lysis of the pathogen Clostridium difficile, a major cause of nosocomial infection. We report a structural and functional analysis of the catalytic activity of CD27L against C. difficile and other bacterial strains. We show that truncation of the endolysin to the N-termin
• PMID 21803993

• LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly.

• Frankel MB, Hendrickx AP, Missiakas DM, Schneewind O.SourceDepartment of Microbiology, University of Chicago, Chicago, Illinois 60637, USA.
• The Journal of biological chemistry.J Biol Chem.2011 Sep 16;286(37):32593-605. Epub 2011 Jul 22.
• Cell cycle progression for the spherical microbe Staphylococcus aureus requires the coordinated synthesis and remodeling of peptidoglycan. The majority of these rearrangements takes place at the mid-cell, in a compartment designated the cross-wall. Secreted polypeptides endowed with a YSIRK-G/S sign
• PMID 21784864

Japanese Journal

• Porphyromonas gingivalisの自己融解酵素変異株の性状

• 鎌口 有秀,宮川 博史,中澤 太
• 北海道医療大学歯学会雑誌 24(1), 41-46, 2005-06-30
• … The results of a BLAST search for autolysin indicated that one ORF was indentified as an autolysin which had 39% homology (58/147 amino acids) with the N-acetylmuramoyl-L-alanine amidase like protein of Clostridium tetani. …
• NAID 110004622817

• Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase

• WANG Z. M.
• Journal of Biological Chemistry 278, 49044-49052, 2003
• NAID 80016373310

• Overexpression, Purification, and Characteriaztion of Bacillus subtilis N-Acetylmuramoyl-L-alanine Amidase CwlC

• Shida Toshio,Hattori Hiromi,Ise Fuminori [他],SEKIGUCHI Junichi
• Bioscience, biotechnology, and biochemistry 64(7), 1522-1525, 2000-07-23
• … N-acetylmuramoyl-L-alanine amidase CwlC of Bacillus subtilis was overproduced in Escherichia coli and purified 21-fold. … The amidase hydrolyzed type A cell walls such as B. … The amidase bound slightly to the Microbacterium lacticum cell wall (type B), but did not entirely hydrolyze it. …
• NAID 110002680123

Related Links

• N-Acetylmuramoyl-L-alanine Amidase - RightDiagnosis.com

N-Acetylmuramoyl-L-alanine Amidase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: N-Acetylmuramoyl-L-alanine Amidase Description of N ...

• N-Acetylmuramoyl-L-alanine Amidase | BU Profiles

"N-Acetylmuramoyl-L-alanine Amidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ... Definition | Details | More General Concepts | Related ...

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★リンクテーブル★

リンク元	「N-アセチルムラモイル-L-アラニンアミダーゼ」
関連記事	「n」「L」「N」「alanine」「Nd」

「N-アセチルムラモイル-L-アラニンアミダーゼ」

　　[★]

英

N-acetylmuramoyl-L-alanine amidase

関

自己溶菌酵素

「n」

　　[★]

• n.

• 例数

関

number of experiment、sample size

• pの前の[n]はmと記載する。synptom→symptom

「L」

　　[★]

• リシジン
• リンキング数
• ロイシン
• free ligand concentration

　 　

「N」

　　[★]

• アスパラギン asparagine
• 窒素(原子、分子)

　 　

「alanine」

　　[★]

アラニン

関

A、Ala、alanyl、L-alanine

　

「Nd」

　　[★] ネオジム neodymium