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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/04 16:02:30」(JST)

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An autolysin is an enzyme (EC 3.4.24.38, gametolysin, Chlamydomonas cell wall degrading protease, lysin, Chlamydomonas reinhardtii metalloproteinase, gamete lytic enzyme, gamete autolysin) that hydrolyzes (and breaks down) the components of a biological cell or a tissue in which it is produced.^[1]^[2]^[3] It is similar in function to a lysozyme. This enzyme catalyses the following chemical reaction

Cleavage of the proline- and hydroxyproline-rich proteins of the Chlamydomonas cell wall; also cleaves azocasein, gelatin and Leu-Trp-Met-Arg-Phe-Ala

This glycoprotein is present in Chlamydomonas reinhardtii gametes.

Autolysins exist in all bacteria containing peptidoglycan. The peptidoglycan matrix is very rigid, so these enzymes break down the peptidoglycan matrix in small sections so that growth and division of cells can occur. Autolysins do this by hydrolyzing the β-(1,4) bond between N-acetylmuramic acid and N-acetylglucosamine molecules. Autolysins are naturally produced by peptidoglycan containing bacteria, but excessive amounts will degrade the peptidoglycan matrix and cause the cell to burst due to osmotic pressure. Gram-positive bacteria regulate autolysins with teichoic acid molecules attached to the tetrapeptide of the peptidoglycan matrix.^[4]

Tariq Bangash Microbiology Kohat University of Science & Technology 2014

References

^ Jaenicke, L., Kunhe, W., Spessert, R., Wahle, U. and Waffenschmidt, S. (1987). "Cell-wall lytic enzymes (autolysins) of Chlamydomonas reinhardtii are (hydroxy)proline-specific proteases". Eur. J. Biochem. 170: 485–491. doi:10.1111/j.1432-1033.1987.tb13725.x. PMID 3319620.
^ Buchanan, M.J., Imam, S.H., Eskue, W.A. and Snell, W.J. (1989). "Activation of the cell wall degrading protease, lysin, during sexual signalling in Chlamydomonas: the enzyme is stored as an inactive, higher relative molecular mass precursor in the periplasm". J. Cell. Biol. 108: 199–207. doi:10.1083/jcb.108.1.199. PMID 2910877.
^ Matsuda, Y. (1998). "Gametolysin". In Barrett, A.J., Rawlings, N.D. & Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. pp. 1140–1143.
^ Smith, Thomas; Steve Blackman; Simon Foster (2000). "Autolysins of Bacillus subtilis: multiple enzymes with multiple functions". Microbiology (Reading: Society for General Microbiology). 146 ( Pt 2) (146): 249–262. doi:10.1099/00221287-146-2-249. PMID 10708363. Retrieved 2007-10-07.

Bao Quoc Tran. Autolysin and its affect on herpes. Microbiology text book ed 5 2012

External links

Gametolysin at the US National Library of Medicine Medical Subject Headings (MeSH)

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リンク元	「自己溶菌酵素」「N-acetylmuramoyl-L-alanine amidase」

「自己溶菌酵素」

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Gametolysin
Identifiers
EC number	3.4.24.38
CAS number	97089-74-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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NCBI	proteins