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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/04 16:02:30」(JST)
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Gametolysin |
Identifiers |
EC number |
3.4.24.38 |
CAS number |
97089-74-2 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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An autolysin is an enzyme (EC 3.4.24.38, gametolysin, Chlamydomonas cell wall degrading protease, lysin, Chlamydomonas reinhardtii metalloproteinase, gamete lytic enzyme, gamete autolysin) that hydrolyzes (and breaks down) the components of a biological cell or a tissue in which it is produced.[1][2][3] It is similar in function to a lysozyme. This enzyme catalyses the following chemical reaction
- Cleavage of the proline- and hydroxyproline-rich proteins of the Chlamydomonas cell wall; also cleaves azocasein, gelatin and Leu-Trp-Met-Arg-Phe-Ala
This glycoprotein is present in Chlamydomonas reinhardtii gametes.
Autolysins exist in all bacteria containing peptidoglycan. The peptidoglycan matrix is very rigid, so these enzymes break down the peptidoglycan matrix in small sections so that growth and division of cells can occur. Autolysins do this by hydrolyzing the β-(1,4) bond between N-acetylmuramic acid and N-acetylglucosamine molecules. Autolysins are naturally produced by peptidoglycan containing bacteria, but excessive amounts will degrade the peptidoglycan matrix and cause the cell to burst due to osmotic pressure. Gram-positive bacteria regulate autolysins with teichoic acid molecules attached to the tetrapeptide of the peptidoglycan matrix.[4]
Tariq Bangash Microbiology Kohat University of Science & Technology 2014
References
- ^ Jaenicke, L., Kunhe, W., Spessert, R., Wahle, U. and Waffenschmidt, S. (1987). "Cell-wall lytic enzymes (autolysins) of Chlamydomonas reinhardtii are (hydroxy)proline-specific proteases". Eur. J. Biochem. 170: 485–491. doi:10.1111/j.1432-1033.1987.tb13725.x. PMID 3319620.
- ^ Buchanan, M.J., Imam, S.H., Eskue, W.A. and Snell, W.J. (1989). "Activation of the cell wall degrading protease, lysin, during sexual signalling in Chlamydomonas: the enzyme is stored as an inactive, higher relative molecular mass precursor in the periplasm". J. Cell. Biol. 108: 199–207. doi:10.1083/jcb.108.1.199. PMID 2910877.
- ^ Matsuda, Y. (1998). "Gametolysin". In Barrett, A.J., Rawlings, N.D. & Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. pp. 1140–1143.
- ^ Smith, Thomas; Steve Blackman; Simon Foster (2000). "Autolysins of Bacillus subtilis: multiple enzymes with multiple functions". Microbiology (Reading: Society for General Microbiology). 146 ( Pt 2) (146): 249–262. doi:10.1099/00221287-146-2-249. PMID 10708363. Retrieved 2007-10-07.
Bao Quoc Tran. Autolysin and its affect on herpes. Microbiology text book ed 5 2012
External links
- Gametolysin at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Domain function dissection and catalytic properties of Listeria monocytogenes p60 protein with bacteriolytic activity.
- Yu M1, Zuo J1, Gu H1, Guo M2, Yin Y1.
- Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2015 Dec;99(24):10527-37. doi: 10.1007/s00253-015-6967-5. Epub 2015 Sep 12.
- The major extracellular protein p60 of Listeria monocytogenes (Lm-p60) is an autolysin that can hydrolyze the peptidoglycan of bacterial cell wall and has been shown to be required for L. monocytogenes virulence. The predicted three-dimensional structure of Lm-p60 showed that Lm-p60 could be split i
- PMID 26363556
- Important Contribution of the Novel Locus comEB to Extracellular DNA-Dependent Staphylococcus lugdunensis Biofilm Formation.
- Rajendran NB1, Eikmeier J1, Becker K2, Hussain M1, Peters G2, Heilmann C3.
- Infection and immunity.Infect Immun.2015 Dec;83(12):4682-92. doi: 10.1128/IAI.00775-15. Epub 2015 Sep 28.
- The coagulase-negative species Staphylococcus lugdunensis is an emerging cause of serious and potentially life-threatening infections, such as infective endocarditis. The pathogenesis of these infections is characterized by the ability of S. lugdunensis to form biofilms on either biotic or abiotic s
- PMID 26416910
- Exoproteome analysis reveals higher abundance of proteins linked to alkaline stress in persistent Listeria monocytogenes strains.
- Rychli K1, Grunert T2, Ciolacu L3, Zaiser A4, Razzazi-Fazeli E5, Schmitz-Esser S6, Ehling-Schulz M7, Wagner M8.
- International journal of food microbiology.Int J Food Microbiol.2015 Nov 10;218:17-26. doi: 10.1016/j.ijfoodmicro.2015.11.002. [Epub ahead of print]
- The foodborne pathogen Listeria monocytogenes, responsible for listeriosis a rare but severe infection disease, can survive in the food processing environment for month or even years. So-called persistent L. monocytogenes strains greatly increase the risk of (re)contamination of food products, and a
- PMID 26594790
Japanese Journal
- 3Ca14 枯草菌細部壁溶解酵素阻害タンパク質IseAの立体構造解析 : 特徴的な阻害ループを持つ弓鋸新規構造の解明(酵素学,酵素工学,一般講演)
- 1PT106 枯草菌細胞壁溶解酸素阻害タンパク質IseAの立体構造解析 : 特徴的な阻害ループを持つ弓鋸型新規構造の解明(日本生物物理学会第50回年会(2012年度))
- 2P-1019 枯草菌細胞伸長におけるLytE,CwlO細胞壁溶解酵素の機能解析(1b遺伝子工学,一般講演,遺伝学,分子生物学および遺伝子工学,伝統の技と先端科学技術の融合)
Related Links
- Autolysin definition, any agent producing autolysis. See more. Thesaurus Translate Puzzles & Games Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In follow Dictionary.com Dictionary Thesaurus ...
- autolysin [aw-tol´ĭ-sin] a lysin originating in an organism and capable of destroying its own cells and tissues. au·tol·y·sin (aw-tol'i-sin), An antibody that in the presence of complement causes lysis of the cells and tissues in the body of ...
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