WordNet

the 14th letter of the Roman alphabet (同)n
the organic group of acetic acid (CH3CO-) (同)acetyl_group, acetyl radical, ethanoyl group, ethanoyl radical
an amino derivative of glucose that is a component of many polysaccharides

PrepTutorEJDIC

nitrogenの化学記号
neodymiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/29 01:02:08」(JST)

wiki en

N-Acetylglucosamine (N-acetyl-D-glucosamine, or GlcNAc, or NAG) is a monosaccharide derivative of glucose. It is an amide between glucosamine and acetic acid. It has a molecular formula of C₈H₁₅NO₆, a molar mass of 221.21 g/mol, and it is significant in several biological systems.

It is part of a biopolymer in the bacterial cell wall, built from alternating units of GlcNAc and N-acetylmuramic acid (MurNAc), cross-linked with oligopeptides at the lactic acid residue of MurNAc. This layered structure is called peptidoglycan (formerly called murein).

GlcNAc is the monomeric unit of the polymer chitin, which forms the outer coverings of insects and crustaceans. It is the main component of the radulas of mollusks, the beaks of cephalopods, and a major component of the cell walls of most Fungi.

Polymerized with glucuronic acid, it forms hyaluronan.

GlcNAc has been reported to be an inhibitor of elastase release from human polymorphonulear leukocytes (range 8 - 17% inhibition), however this is much weaker than the inhibition seen with N-acetyl-galactosamine (range 92 - 100%).^[1]

Medical uses

It has been proposed as a treatment for autoimmune diseases,^[2] and recent tests have claimed some success.^[3]

References

^ Kamel, M; Hanafi, M; Bassiouni, M (1991). "Inhibition of elastase enzyme release from human polymorphonuclear leukocytes by N-acetyl-galactosamine and N-acetyl-glucosamine". Clinical and experimental rheumatology 9 (1): 17–21. PMID 2054963. edit
^ "Sugar supplement may treat immune disease - health - 07 June 2007 - New Scientist". Retrieved 2007-06-08.
^ "Glucosamine-Like Supplement Suppresses Multiple Sclerosis Attacks, Study Suggests". Science Daily.

External links

Re Multiple Sclerosis

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. マンノース結合レクチン mannose binding lectin
2. 急性リウマチ熱の疫学および病因 epidemiology and pathogenesis of acute rheumatic fever
3. シデナム舞踏病 sydenham chorea
4. 漢方薬および栄養補助食品の概要 overview of herbal medicine and dietary supplements
5. 亜急性および慢性腰痛：薬物治療と非侵襲的治療 subacute and chronic low back pain pharmacologic and noninterventional treatment

English Journal

Single cell profiling of surface carbohydrates on Bacillus cereus.

Wang C1, Ehrhardt CJ2, Yadavalli VK3.
Journal of the Royal Society, Interface / the Royal Society.J R Soc Interface.2015 Feb 6;12(103). pii: 20141109. doi: 10.1098/rsif.2014.1109.
Cell surface carbohydrates are important to various bacterial activities and functions. It is well known that different types of Bacillus display heterogeneity of surface carbohydrate compositions, but detection of their presence, quantitation and estimation of variation at the single cell level hav
PMID 25505137

Effect of the urease-derived peptide Jaburetox on the central nervous system of Triatoma infestans (Insecta: Heteroptera).

Galvani GL1, Fruttero LL2, Coronel MF3, Nowicki S4, Demartini DR5, Defferrari MS6, Postal M7, Canavoso LE8, Carlini CR9, Settembrini BP10.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Feb;1850(2):255-62. doi: 10.1016/j.bbagen.2014.11.008. Epub 2014 Nov 13.
BACKGROUND: Triatoma infestans is the main vector of Chagas'disease in Southern Cone countries. In triatomines, symptoms suggesting neurotoxicity were observed after treatment with Jaburetox (Jbtx), the entomotoxic peptide obtained from jackbean urease. Here, we study its effect in the central nervo
PMID 25445710

An optimal glucose feeding strategy integrated with step-wise regulation of the dissolved oxygen level improves N-acetylglucosamine production in recombinant Bacillus subtilis.

Zhu Y1, Liu Y2, Li J3, Shin HD4, Du G5, Liu L6, Chen J7.
Bioresource technology.Bioresour Technol.2015 Feb;177:387-92. doi: 10.1016/j.biortech.2014.11.055. Epub 2014 Nov 20.
In our previous work, a recombinant Bacillus subtilis strain for the microbial production of N-acetylglucosamine (GlcNAc) was constructed through modular pathway engineering. In this study, to enhance GlcNAc production, glucose feeding approaches and dissolved oxygen (DO) control methods in fed-batc
PMID 25499147

Japanese Journal

Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling.

Babazada Hasan,Yamashita Fumiyoshi,Yanamoto Shinya,Hashida Mitsuru
Journal of controlled release 194, 332-340, 2014-11-28
… In line with these findings, 6-O-sulfate groups of d-glucosamine residue were essential for effective inhibition, while removal of 2-O-sulfo and 3-O-sulfo groups as well as replacement of N-sulfo groups with N-acetyl did not alter anti-inflammatory activity. …
NAID 120005512273

Characterization of Mannose Isomerase from a Cellulolytic Actinobacteria Thermobifida fusca MBL10003

Kasumi Takafumi,Mori Sumiko,Kaneko Satoshi,Matsumoto Hitoshi,Kobayashi Yousuke,Koyama Yoshiyuki
Journal of Applied Glycoscience 61(1), 21-25, 2014
… It showed activity on D-mannose and also on D-lyxose, but not on N-acetyl D-glucosamine, suggesting that it is functionally different from N-acyl D-glucosamine 2-epimerase despite the sequence similarity. …
NAID 130004481035

Modulation of acceptor specificity of Ruminococcus albus cellobiose phosphorylase through site-directed mutagenesis

Hamura Ken,Saburi Wataru,Matsui Hirokazu,Mori Haruhide
Carbohydrate research 379, 21-25, 2013-09-20
… C485A showed higher preference for D-glucosamine than the wild type. … Y648V had synthetic activity toward N-acetyl-D-glucosamine, while the other variants did not. … C485A produced 4-O-beta-D-glucopyranosyl-D-glucosamine from 10 mM Glc1P and D-glucosamine at a rate similar to the wild type. …
NAID 120005348940

「N-アセチルグルコサミン」

N-Acetylglucosamine
Names
	IUPAC name 2-(Acetylamino)-2-deoxy-D-glucose
	Other names N-Acetyl-D-Glucosamine; GlcNAc; NAG
Identifiers
CAS Registry Number	7512-17-6
ChEBI	CHEBI:28009
ChEMBL	ChEMBL447878
ChemSpider	22563
	InChI InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1 ; Key: OVRNDRQMDRJTHS-FMDGEEDCSA-N ; InChI=1/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1; Key: OVRNDRQMDRJTHS-FMDGEEDCBL ;
Jmol-3D images	Image
PubChem	24139
	SMILES O=C(N[C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@H]1O)CO)C ;
UNII	V956696549
Properties
Chemical formula	C8H15NO6
Molar mass	221.21
Melting point	211
Hazards
S-phrases	S24/25
Related compounds
Related Monosaccharides	N-Acetylgalactosamine
Related compounds	Glucosamine; Glucose
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is: /?)
	Infobox references

　　[★]

英: N-acetylglucosamine, N-acetyl glucosamine, GlcNAc, NAG
同: N-アセチル-D-グルコサミン N-acetyl-D-glucosamine、N-アセチルキトサミン N-acetylchitosamine
関: N-アセチルグルコサミニダーゼ

「NAG」

　　[★]

「n」

　　[★]

n.

例数

関: number of experiment、sample size

pの前の[n]はmと記載する。synptom→symptom

「N」

　　[★]

アスパラギン asparagine
窒素(原子、分子)

「Nd」

　　[★] ネオジム neodymium 　

「acetyl」

　　[★]

アセチル

関: Ac

[1] Kamel, M; Hanafi, M; Bassiouni, M (1991). "Inhibition of elastase enzyme release from human polymorphonuclear leukocytes by N-acetyl-galactosamine and N-acetyl-glucosamine". Clinical and experimental rheumatology 9 (1): 17–21. PMID 2054963. edit

[2] "Sugar supplement may treat immune disease - health - 07 June 2007 - New Scientist". Retrieved 2007-06-08.

[3] "Glucosamine-Like Supplement Suppresses Multiple Sclerosis Attacks, Study Suggests". Science Daily.

リンク元	「N-アセチルグルコサミン」「NAG」
関連記事	「n」「N」「Nd」「acetyl」

匿名

検索

案内

案内

N-acetyl glucosamine