メチルメチオニンスルホニウムクロリド methylmethionine sulfonium chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/04 14:03:07」(JST)

English Journal

Stable Genetic Alterations of β-Catenin and ROR2 Regulate the Wnt Pathway, Affect the Fate of MSCs.

Cai SX1, Liu AR, He HL, Chen QH, Yang Y, Guo FM, Huang YZ, Liu L, Qiu HB.Author information 1Department of Critical Care Medicine, Nanjing Zhong-da Hospital, School of Medicine, Southeast University, Nanjing, P.R. China.AbstractThe Wnt pathways have been shown to be critical for the fate of mesenchymal stem cells (MSCs) in vitro, but their roles in MSCs in vivo remain poorly characterized due to the lack of stable alterations in their signaling. In the present study, we constructed long-term and stable mMSCs lines with activated and inactivated β-catenin (the key molecule of the canonical Wnt signaling pathway) or ROR2 (the key molecule of the noncanonical Wnt5a/ROR2 signaling pathway) modifications with lentiviral vectors. We found that the transduction efficiencies mediated by the lentiviral vectors were 92.61-97.04% and were maintained over 20 passages of mMSCs. Transfection by lentiviral vectors not only regulated the mRNA and protein expression of β-catenin or ROR2 but also regulated nuclear β-catenin accumulation or the Wnt5a/JNK and Wnt5a/PKC pathways belonging to the canonical Wnt and noncanonical Wnt5a/ROR2 pathways, respectively. β-Catenin or ROR2 gene overexpression promoted mMSC proliferation, migration and differentiation into osteoblasts, while inhibiting the adipogenic differentiation of mMSCs. In contrast, inactivation of the β-catenin or ROR2 genes resulted in the opposite effects. Therefore, these results confirm that lentiviral vector transduction can facilitate sustained and efficient gene modification of the Wnt pathway in mMSCs. This study provides a method to investigate the effects of the Wnt pathway on the fate of mMSCs in vivo and for the further improvement of MSC-based therapies. J. Cell. Physiol. 229: 791-800, 2014. © 2013 Wiley Periodicals, Inc.
Journal of cellular physiology.J Cell Physiol.2014 Jun;229(6):791-800. doi: 10.1002/jcp.24500.
The Wnt pathways have been shown to be critical for the fate of mesenchymal stem cells (MSCs) in vitro, but their roles in MSCs in vivo remain poorly characterized due to the lack of stable alterations in their signaling. In the present study, we constructed long-term and stable mMSCs lines with act
PMID 24590964

Wound bed preparation 2014 update: management of critical colonization with a gentian violet and methylene blue absorbent antibacterial dressing and elevated levels of matrix metalloproteases with an ovine collagen extracellular matrix dressing.

Sibbald RG1, Ovington LG, Ayello EA, Goodman L, Elliott JA.Author information 1R. Gary Sibbald, BSc, MD, MEd, FRCPC(Med Derm), MACP, FAAD, MAPWCA, is Professor of Public Health and Medicine, University of Toronto, Ontario, Canada; Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana School of Public Health, University of Toronto; Past President, World Union of Wound Healing Societies; Course Coordinator, International Interprofessional Wound Care Course at New York University Medical Center, and Clinical Editor, Advances in Skin & Wound Care, Philadelphia, Pennsylvania. Liza G. Ovington, PhD, FACCWS, is Director, Medical Operations, Global Surgery Group, Ethicon Inc, Somerville, New Jersey. Elizabeth A. Ayello, PhD, RN, ACNS-BC, CWON, ETN, MAPCWA, FAAN, is Faculty, Excelsior College of Nursing, Albany, New York; Senior Advisor, The John A. Hartford Institute for Geriatric Nursing, New York; President, Ayello, Harris & Associates, New York; Course Coordinator, International Interprofessional Wound Care Course at New York University Medical Center; and Clinical Editor, Advances in Skin & Wound Care, Philadelphia, Pennsylvania. Laurie Goodman, MHScN, BA, RN, IIWCC (Toronto), is an Advanced Practice Nurse and Wound Educator, Toronto Regional Wound Healing Clinics, Ontario, Canada. James A. Elliott, MMsc, BSc, is an independent researcher, Toronto, Canada. Dr Sibbald has disclosed that his employer, the University of Toronto, is the recipient of an unconditional educational grant from Hollister Inc, research grants from Healthpoint Biotherapeutics, Systagenix, and Exiton, and was the recipient of research grants from the Government of Ontario, 3M, BSN, CIDA, Coloplast, Covidien, Gaymar, KCI, Johnson & Johnson, Registered Nurses Association of Ontario, Mölnlycke, Hollister Limited, Valeant, Shire, Galderma, Leo, Stiefel, Abbott, and Mississauga Halton Community Care Access Center; he is a board member of 3M, BSN, Coloplast, Covidien, Gaymar, KCI, Systagenix, MölnAbstractWound bed preparation (WBP) is a paradigm for holistic patient care that includes treatment of the cause along with patient-centered concerns before optimizing the components of local wound care (debridement, infection/inflammation, moisture balance, and, when required, the edge effect). This review incorporates a methylene blue and gentian violet bound foam dressing for critical colonization and an ovine collagen extracellular matrix dressing for reduction of elevated levels of matrix metalloproteases into the WBP paradigm.
Advances in skin & wound care.Adv Skin Wound Care.2014 Mar;27(3 Suppl 1):1-6. doi: 10.1097/01.ASW.0000443269.63406.f9.
Wound bed preparation (WBP) is a paradigm for holistic patient care that includes treatment of the cause along with patient-centered concerns before optimizing the components of local wound care (debridement, infection/inflammation, moisture balance, and, when required, the edge effect). This review
PMID 24521847

An electrochemical investigation of TMJ implant metal alloys in an artificial joint fluid environment: The influence of pH variation.

Royhman D1, Radhakrishnan R2, Yuan JC3, Mathew MT1, Mercuri LG4, Sukotjo C5.Author information 1University of Illinois at Chicago College of Dentistry, Department of Restorative Dentistry (Head: Dr. Stephen Campbell, DDS, MMSc), 801 S. Paulina Ave, Chicago, IL 60612, USA; Rush University Medical Center, Department of Orthopedics (Head: Dr. Joshua Jacobs, MD), 1611 W. Harrison St., Chicago, IL 60612, USA.2Rush University Medical Center, Department of Orthopedics (Head: Dr. Joshua Jacobs, MD), 1611 W. Harrison St., Chicago, IL 60612, USA.3University of Illinois at Chicago College of Dentistry, Department of Restorative Dentistry (Head: Dr. Stephen Campbell, DDS, MMSc), 801 S. Paulina Ave, Chicago, IL 60612, USA.4Rush University Medical Center, Department of Orthopedics (Head: Dr. Joshua Jacobs, MD), 1611 W. Harrison St., Chicago, IL 60612, USA; TMJ Concepts, 2233 Knoll Drive, Ventura, CA 93003, USA.5University of Illinois at Chicago College of Dentistry, Department of Restorative Dentistry (Head: Dr. Stephen Campbell, DDS, MMSc), 801 S. Paulina Ave, Chicago, IL 60612, USA. Electronic address: csukotjo@uic.edu.AbstractOBJECTIVE: To investigate the corrosion behaviour of commonly used TMJ implants alloys (CoCrMo and Ti6Al4V) under simulated physiological conditions.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.J Craniomaxillofac Surg.2014 Jan 23. pii: S1010-5182(14)00031-6. doi: 10.1016/j.jcms.2014.01.029. [Epub ahead of print]
OBJECTIVE: To investigate the corrosion behaviour of commonly used TMJ implants alloys (CoCrMo and Ti6Al4V) under simulated physiological conditions.METHODS: Corrosion behaviour was evaluated using standard electrochemical corrosion techniques and galvanic corrosion techniques as per ASTM standards.
PMID 24548869

Japanese Journal

胃粘膜傷害における胃・十二指腸ムチンの量的・質的変動に対するメチルメチオニンスルホニウムクロライド(MMSC)後投与の効果

伊東祐子,岡田諭起,三枝陽一,岩井知久,市川尊文,五艘行信,池澤智明,石原和彦
潰瘍 = Ulcer research 35(2), 126-131, 2008-12-25
NAID 10025371302

ラット塩酸アスピリン胃粘膜傷害における胃十二指腸ムチンの量的質的変動に対するメチルメチオニンスルホニウムクロライド (MMSC) 後投与の効果

伊東祐子
薬理と治療 35, 41-49, 2007
NAID 80018714072

メチルメチオニンスルホニウムクロライド (MMSC) のラット胃粘膜細胞に対する保護作用について

岡部進
Therapeutic Res. 17, 3663-3669, 1996
NAID 80009197689

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