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the 13th letter of the Roman alphabet (同)m

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Mach number / mark[s] / Monsieur

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/15 19:32:01」(JST)

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1. 慢性閉塞性肺疾患（COPD）：危険因子およびリスク低減 chronic obstructive pulmonary disease risk factors and risk reduction
2. 変形性関節症の病因 pathogenesis of osteoarthritis
3. 腹部大動脈瘤の疫学、危険因子、病因および自然経過 epidemiology risk factors pathogenesis and natural history of abdominal aortic aneurysm

English Journal

Metalloproteinases in metabolic syndrome.

Berg G, Miksztowicz V, Schreier L.AbstractExperimental and clinical evidence supports the concept that metalloproteinases (MMPs), beyond different physiologic functions, also play a role in the development and rupture of the atherosclerotic plaque. Interest in MMPs has been rapidly increasing during the last years, especially as they have been proposed as biomarkers of vulnerable plaques. Different components of the metabolic syndrome (MS) have been identified as possible stimulus for the synthesis and activity of MMPs, like pro-inflammatory and pro-oxidant state, hyperglycemia, hypertension and dyslipidemia. On the other hand, anti-inflammatory cytokines like adiponectin are inversely associated with MMPs. Among the several MMPs studied, collagenases (MMP-1 and MMP-8) and gelatinases (MMP-2 and MMP-9) are the most associated with MS. Our aim was to summarize and discuss the relation between different components of the MS on MMPs, as well as the effect of the cluster of the metabolic alterations itself. It also highlights the necessity of further studies, in both animals and humans, to elucidate the function of novel MMPs identified, as well as the role of the known enzymes in different steps of metabolic diseases. Understanding the mechanisms of MS impact on MMPs and vice versa is an interesting area of research that will positively enhance our understanding of the complexity of MS and atherosclerosis.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2011 Sep 18;412(19-20):1731-9. Epub 2011 Jun 17.
Experimental and clinical evidence supports the concept that metalloproteinases (MMPs), beyond different physiologic functions, also play a role in the development and rupture of the atherosclerotic plaque. Interest in MMPs has been rapidly increasing during the last years, especially as they have b
PMID 21703252

Consistent alterations of circulating matrix metalloproteinases levels in untreated hypertensives and in spontaneously hypertensive rats: a relevant pharmacological target.

Fontana V, Silva PS, Belo VA, Antonio RC, Ceron CS, Biagi C, Gerlach RF, Tanus-Santos JE.SourceDepartment of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil Department of Pharmacology, Faculty of Medicinal Sciences, University of Campinas, State University of Campinas, Campinas, SP, Brazil Santa Casa of Aracatuba, Aracatuba, SP, Brazil Department of Morphology, Estomatology and Physiology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Basic & clinical pharmacology & toxicology.Basic Clin Pharmacol Toxicol.2011 Aug;109(2):130-7. doi: 10.1111/j.1742-7843.2011.00698.x. Epub 2011 Apr 4.
Inconsistent matrix metalloproteinases (MMPs) levels have been reported in hypertension, with higher, similar and lower MMPs levels reported in hypertensives compared with normotensives. Differences between studies may reflect lack of control of drug effects, accompanying diseases and pre-analytical
PMID 21401887

Japanese Journal

Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Down's syndrome

Yamazaki-Kubota T,Miyamoto M,Sano Y,Kusumoto M,Yonezu T,Sugita K,Okuda K,Yakushiji M,Ishihara K
Journal of periodontal research 45(2), 170-176, 2010-04
NAID 120002165339

Bone mineral density, bone mineral content, gingival crevicular fluid (matrix metalloproteinases, cathepsin K, osteocalcin), and salivary and serum osteocalcin levels in human mandible and alveolar bone under conditions of simulated microgravity

Rai Balwant,Kaur Jasdeep,Catalina Maria
Journal of Oral Science 52(3), 385-390, 2010
… matrix metalloproteinase (MMP)-8, MMP-9, cathepsin K, and osteocalcin levels in gingival crevicular fluid (GCF); … GCF (ie, MMP-8, MMP-9, cathepsin K, and osteocalcin) and salivary and serum osteocalcin levels were measured by enzyme-linked immunosorbent assays. …
NAID 130000438417