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Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.

Gencer S, Cebeci A, Irmak-Yazicioglu MB.SourceDepartment of Genetics and Bioengineering, Faculty of Engineering, Fatih University, Istanbul 34500, Turkey; ; Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul 34662, Turkey;
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu.Chin J Cancer Res.2013 Jun;25(3):322-33. doi: 10.3978/j.issn.1000-9604.2013.06.05.
OBJECTIVE: Oxidative stress is linked to increased risk of gastric cancer and matrix metalloproteinases (MMPs) are important in the invasion and metastasis of gastric cancer. We aimed to analyze the effect of the accumulation of oxidative stress in the gastric cancer MKN-45 and 23132/87 cells follow
PMID 23825909

Multiple steps of HLA-G in ovarian carcinoma metastasis: alter NK cytotoxicity and induce matrix metalloproteinase-15 (MMP-15) expression.

Lin A, Xu HH, Xu DP, Zhang X, Wang Q, Yan WH.SourceMedical Research Center, Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang 317000, PR China.
Human immunology.Hum Immunol.2013 Apr;74(4):439-46. doi: 10.1016/j.humimm.2012.11.021. Epub 2012 Dec 8.
Previous study showed that aberrant HLA-G expression in cancer cells plays important roles in disease progression and it was associated with tumor metastasis and with poor survival in an animal model with ovarian cancer; however, the mechanisms remain to be explored. In this study, we found that HLA
PMID 23228395

Differentiated expression of membrane type metalloproteinases (MMP-14, MMP-15) and pro-MMP2 in laryngeal squamous cell carcinoma. A novel mechanism.

Bodnar M, Szylberg L, Kazmierczak W, Marszalek A.SourceDepartment of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Bydgoszcz, Poland.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.J Oral Pathol Med.2013 Mar;42(3):267-74. doi: 10.1111/jop.12000. Epub 2012 Sep 23.
Cancer progression involves multiple proteolytic interactions, with metalloproteinases (MMPs) performing a crucial role. MMP-2, a major MMP, plays a key role in the degradation of basement membranes. Mechanisms underlying MMP-2 activation had to be investigated. Membrane-type matrix metalloproteinas
PMID 22998427