WordNet

PrepTutorEJDIC

Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide specific binding pocket that distinguishes N-glycan phosphorylation in a branch specific manner.

Blackler RJ1, Evans DW1, Smith DF2, Cummings RD2, Brooks CL1, Braulke T3, Liu X4, Evans SV5, Müller-Loennies S6.
Glycobiology.Glycobiology.2015 Oct 26. pii: cwv093. [Epub ahead of print]
The acquisition of mannose 6-phosphate (Man6P) on N-linked glycans of lysosomal enzymes is a structural requirement for their transport from the Golgi apparatus to lysosomes mediated by the mannose 6-phosphate receptors, MPR300 and MPR46. Here we report that the single-chain variable domain (scFv) M
PMID 26503547

Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of subclinical atherosclerosis in Chinese patients with newly diagnosed type 2 diabetes: A cross-sectional study.

Zheng TP1, Liu YH2, Yang LX3, Qin SH4, Liu HB5.
Atherosclerosis.Atherosclerosis.2015 Oct;242(2):580-8. doi: 10.1016/j.atherosclerosis.2015.07.042. Epub 2015 Jul 26.
OBJECTIVE: Hyperglycemia, insulin resistance, dislipidemia, oxidative stress and inflammation are well-documented risk factors for subclinical atherosclerosis. Dipeptidyl peptidase-4(DPP4) is a newly identified adipokine related to these risk factors. Hence, we aimed to investigate the association b
PMID 26318108

Blanz J1, Zunke F1, Markmann S2, Damme M1, Braulke T2, Saftig P1, Schwake M3.
Traffic (Copenhagen, Denmark).Traffic.2015 Oct;16(10):1127-36. doi: 10.1111/tra.12313. Epub 2015 Sep 1.
The lysosomal integral membrane protein type 2 (LIMP-2/SCARB2) has been described as a mannose 6-phosphate (M6P)-independent trafficking receptor for β-glucocerebrosidase (GC). Recently, a putative M6P residue in a crystal structure of a recombinantly expressed LIMP-2 ectodomain has been reported.
PMID 26219725