ドロキシドパ
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 起立性低血圧および食後低血圧の治療treatment of orthostatic and postprandial hypotension [show details]
…midodrine. L-dihydroxyphenylserine (DOPS, droxidopa) is a synthetic amino acid, identical to levodopa but with an added hydroxyl group. After oral administration, droxidopa is decarboxylated to norepinephrine …
- 2. パーキンソン病とパーキンソン症候群への対症療法palliative approach to parkinson disease and parkinsonian disorders [show details]
…binders), and exercise. Pharmacologic therapy includes medications such as fludrocortisone, midodrine, droxidopa, and pyridostigmine. Slowed gastrointestinal motility is a prominent nonmotor feature of PD related…
- 3. パーキンソン病の非運動症状のマネージメントmanagement of nonmotor symptoms in parkinson disease [show details]
…treatments are reserved for symptomatic patients who do not respond to these measures. Options include droxidopa, fludrocortisone, and midodrine, though these may lead to supine hypertension . Pyridostigmine may…
- 4. 糖尿病性自律神経障害diabetic autonomic neuropathy [show details]
…severe supine hypertension, so patients should not use midodrine within six hours of bedtime. Droxidopa, an orally administered norepinephrine prodrug, has received regulatory approval in the United States …
- 5. 多系統萎縮症：予後および治療multiple system atrophy prognosis and treatment [show details]
…include the alpha-1 adrenergic agonist, midodrine, and the norepinephrine precursor, droxidopa. The efficacy of droxidopa was demonstrated in two small studies that included patients with MSA . Supine hypertension…
English Journal
- Ear2 deletion causes early memory and learning deficits in APP/PS1 mice.
- Kummer MP, Hammerschmidt T, Martinez A, Terwel D, Eichele G, Witten A, Figura S, Stoll M, Schwartz S, Pape HC, Schultze JL, Weinshenker D, Heneka MT, Urban I.
- The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Jun;34(26)8845-54.
- To assess the consequences of locus ceruleus (LC) degeneration and subsequent noradrenaline (NA) deficiency in early Alzheimer's disease (AD), mice overexpressing mutant amyloid precursor protein and presenilin-1 (APP/PS1) were crossed with Ear2(-/-) mice that have a severe loss of LC neurons projec
- PMID 24966384
- Optimal production of L-threo-2,3-dihydroxyphenylserine (L-threo-DOPS) on a large scale by diastereoselectivity-enhanced variant of L-threonine aldolase expressed in Escherichia coli.
- Gwon HJ, Yoshioka H, Song NE, Kim JH, Song YR, Jeong DY, Baik SH.
- Preparative biochemistry & biotechnology. 2012 ;42(2)143-54.
- This study examined the efficient production and optimal separation procedures for pure L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) from a mixture of diastereomers synthesized by whole-cell aldol condensation reaction, harboring diastereoselectivity-enhanced L-threonine aldolase in Escherichia
- PMID 22394063
- Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.
- Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP.
- Proceedings of the National Academy of Sciences of the United States of America. 2010 Mar;107(13)6058-63.
- Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on Alzheimer's disease pathology, we evaluated NE effects on microglial key functions. NE stimulation of mouse microglia suppressed Abet
- PMID 20231476
Japanese Journal
- 虚血誘発ラット前庭神経内側核ニューロン活動抑制の L-threo-DOPS による回復作用
- 笹 征史,厳 海燉,石原 熊寿,天野 託,関 貴弘
- 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 22(6), 287, 2002-12-25
- NAID 10012589867
- パーキンソン病の起立性低血圧に対する L-threo-DOPS の効果
- 透析患者の起立性低血圧症状に対する L-threo-DOPS の臨床効果-多施設共同二重盲検比較法による第3相試験-
- 越川 昭三,秋澤 忠男,飯田 喜俊,丸茂 文昭,川口 良人,白井 大禄,今田 聰雄,山崎 親雄,鈴木 正司,椿原 美治,秋葉 隆,中島 光好
- 日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 30(7), 941-959, 1997-07-28
- NAID 10006358401
Related Links
- ドプスの名前の由来は、一般名のドロキシドパ((－)-threo-3-(3,4-dihydroxyphenyl)-L-serine)の下線部から DOPS：ドプス となったようです。 ドプスは主に パーキンソン病におけるすくみ足、たちくらみ に対して用いられます。
- 抄録 l-norepinephrine （NE）の合成前駆物質であるL-threo−3,4-dihydroxyphenylserine。L-DOPS）の痙攣発作に及ぼす影響を，マウスの電撃痙攣モデルを用いて検討した。薬物は全て腹腔内に投与した。L-DOPS （200,400mg／kg）は ...
- L-DOPS, also called L-threo 3,4-Dihydroxyphenylserine or droxidopa is a catecholamine. L-DOPS has many clinical advantages and may be useful for treating norepinephrine deficiency. It is used for treating neurogenic orthostatic
★リンクテーブル★
[★]
- 英
- droxidopa
- 同
- L-threo-dops L-スレオドプス L-threo-dihydroxyphenylserine
- 商
- ドプス
- 関
- 抗パーキンソン剤。パーキンソン病
概念
- ノルアドレナリンの前駆体であって、体内でL-aromatic amino acid decarboxylase(AADC)で脱炭酸され、norepinephrineに変換される。
- パーキンソン病患者ではノルアドレナリンが減少し、すくみ足やsudden transient freezing-upを改善すると言われている。
適応
副作用
[★]
- 関
- carry out、conduct、execute、make、perform、practice、undertake
[★]