WordNet

direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
street names for ketamine (同)jet, super acid, special K, honey oil, green, cat valium, super C
the 11th letter of the Roman alphabet (同)k
a light soft silver-white metallic element of the alkali metal group; oxidizes rapidly in air and reacts violently with water; is abundant in nature in combined forms occurring in sea water and in carnallite and kainite and sylvite (同)K, atomic number 19
official routes of communication; "you have to go through channels"

PrepTutorEJDIC

〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
Kelvin / Kindergarten / (チェスの)King / kalium(ラテン語)(=potassium)の化学記号
ポタシウム,カリウム(金属元素;化学記号はK)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/12 05:08:33」(JST)

wiki en

Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or K_v1.5, is a protein that in humans is encoded by the KCNA5 gene.^[1]

Function

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12.^[1] Mutations in this gene have been related to both atrial fibrillation ^[2] and sudden cardiac death.^[3] KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

Interactions

KCNA5 has been shown to interact with DLG4^[4]^[5] and Actinin, alpha 2.^[4]^[6]

References

^ ^a ^b "Entrez Gene: KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5".
^ Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M, Sattiraju S, Ballew JD, Jahangir A, Terzic A (Jul 2006). "Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation". Human Molecular Genetics 15 (14): 2185–91. doi:10.1093/hmg/ddl143. PMID 16772329.
^ Nielsen NH, Winkel BG, Kanters JK, Schmitt N, Hofman-Bang J, Jensen HS, Bentzen BH, Sigurd B, Larsen LA, Andersen PS, Haunsø S, Kjeldsen K, Grunnet M, Christiansen M, Olesen SP (Mar 2007). "Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients". Biochemical and Biophysical Research Communications 354 (3): 776–82. doi:10.1016/j.bbrc.2007.01.048. PMID 17266934.
^ ^a ^b Eldstrom J, Choi WS, Steele DF, Fedida D (Jul 2003). "SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism". FEBS Letters 547 (1-3): 205–11. doi:10.1016/S0014-5793(03)00668-9. PMID 12860415.
^ Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Letters 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. PMID 12435606.
^ Maruoka ND, Steele DF, Au BP, Dan P, Zhang X, Moore ED, Fedida D (May 2000). "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS Letters 473 (2): 188–94. doi:10.1016/S0014-5793(00)01521-0. PMID 10812072.

External links

Kv1.5 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNA5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 肺動脈性肺高血圧症（グループ1）の疫学と発症機序 the epidemiology and pathogenesis of pulmonary arterial hypertension group 1
2. 赤血球水分量の制御 control of red blood cell hydration
3. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
4. QT延長症候群の病態生理 pathophysiology of the long qt syndrome
5. 心筋活動電位および抗不整脈剤の作用 myocardial action potential and action of antiarrhythmic drugs

English Journal

Disease and region-related cardiac fibroblast potassium current variations and potential functional significance.

Wu CT1, Qi XY2, Huang H2, Naud P2, Dawson K3, Yeh YH4, Harada M5, Kuo CT4, Nattel S6.
Cardiovascular research.Cardiovasc Res.2014 Jun 1;102(3):487-96. doi: 10.1093/cvr/cvu055. Epub 2014 Mar 4.
AIMS: Fibroblasts, which play an important role in cardiac function/dysfunction, including arrhythmogenesis, have voltage-dependent (Kv) currents of unknown importance. Here, we assessed the differential expression of Kv currents between atrial and ventricular fibroblasts from control dogs and dogs
PMID 24596399

Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2.

Wang T1, Hogan-Cann A, Kang Y, Cui Z, Guo J, Yang T, Lamothe SM, Li W, Ma A, Fisher JT, Zhang S.
Molecular pharmacology.Mol Pharmacol.2014 Jun;85(6):877-86. doi: 10.1124/mol.113.091553. Epub 2014 Mar 31.
The human ether-à-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel, which is important for cardiac repolarization. Reduction of hERG current due to genetic mutations or drug interferences causes long QT syndrome, leading to car
PMID 24688054

Design, synthesis and evaluation of phenethylaminoheterocycles as Kv1.5 inhibitors.

Johnson JA1, Xu N2, Jeon Y2, Finlay HJ2, Kover A2, Conder ML3, Sun H3, Li D3, Levesque P3, Hsueh MM4, Harper TW4, Wexler RR2, Lloyd J2.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 May 20. pii: S0960-894X(14)00535-6. doi: 10.1016/j.bmcl.2014.05.035. [Epub ahead of print]
Phenethylaminoheterocycles have been prepared and assayed for inhibition of the Kv1.5 potassium ion channel as a potential approach to the treatment of atrial fibrillation. A diverse set of heterocycles were identified as potent Kv1.5 inhibitors and were advanced to pharmacodynamic evaluation based
PMID 24881565

Japanese Journal

Identification of Verapamil Binding Sites Within Human Kv1.5 Channel Using Mutagenesis and Docking Simulation.

DING Wei-guang,Tano Ayami,Mi Xinya,小嶋亜希子,SETO Tomoyoshi,MATSUURA Hiroshi
Cellular physiology and biochemistry : international journal of experimental cellular physiology 52(2), 302-314, 2019-02-28
… BACKGROUND/The phenylalkylamine class of L-type Ca2+ channel antagonist verapamil prolongs the effective refractory period (ERP) of human atrium, which appears to contribute to the efficacy of verapamil in preventing reentrant-based atrial arrhythmias including atrial fibrillation. …
NAID 120006602350

肺高血圧症の病態と新規治療をカリウムチャネル制御から探る

早渕康信
日本小児循環器学会雑誌 32(3), 189-198, 2016
… domainカリウムチャネルの1種であるKCNK3（TASK1）の遺伝子変異がPAHの原因遺伝子であると証明され，第5回肺高血圧国際シンポジウム（ニース国際会議）で追加された．また，PAHでは発症原因にかかわらず，電位依存性カリウムチャネル，特にKCNA5（Kv1.5）の発現低下と活性抑制が認められ，肺動脈収縮と血管リモデリングを促進することが示されている．さ …
NAID 130005157528

Endocytic Regulation of Voltage-Dependent Potassium Channels in the Heart

Ishii Kuniaki,Norota Ikuo,Obara Yutaro
Journal of pharmacological sciences 120(4), 264-269, 2012-12-20
… Functional changes have been extensively investigated for many ion channels including cardiac voltage-dependent potassium channels. … By contrast, the regulation of ion channel numbers has not been widely examined, particularly with respect to acute modulation of ion channels. … This article briefly summarizes stimulus-induced endocytic regulation of major voltage-dependent potassium channels in the heart. …
NAID 10031147574

「Kv1.5カリウムチャネル」

Potassium channel, voltage gated shaker related subfamily A, member 5
Identifiers
Symbols	KCNA5 ; ATFB7; HCK1; HK2; HPCN1; KV1.5; PCN1
External IDs	OMIM: 176267 MGI: 96662 HomoloGene: 1683 IUPHAR: 542 ChEMBL: 4306 GeneCards: KCNA5 Gene
Gene ontology
Molecular function	• receptor binding; • delayed rectifier potassium channel activity; • protein binding; • outward rectifier potassium channel activity; • potassium channel inhibitor activity; • protein kinase binding; • alpha-actinin binding; • voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization; • voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; • voltage-gated potassium channel activity involved in SA node cell action potential repolarization; • scaffold protein binding;
Cellular component	• endoplasmic reticulum; • Golgi apparatus; • cytosol; • plasma membrane; • integral component of plasma membrane; • caveola; • voltage-gated potassium channel complex; • intercalated disc; • Z disc; • potassium channel complex; • membrane raft; • intracellular canaliculus; • perinuclear region of cytoplasm;
Biological process	• response to hypoxia; • potassium ion transport; • synaptic transmission; • response to mechanical stimulus; • response to organic substance; • regulation of vasoconstriction; • regulation of membrane potential; • response to hydrogen peroxide; • regulation of potassium ion transport; • negative regulation of potassium ion transport; • regulation of insulin secretion; • protein homooligomerization; • negative regulation of cytosolic calcium ion concentration; • potassium ion homeostasis; • response to hyperoxia; • membrane hyperpolarization; • regulation of atrial cardiac muscle cell membrane repolarization; • potassium ion export; • potassium ion transmembrane transport; • atrial cardiac muscle cell action potential; • membrane repolarization during bundle of His cell action potential; • membrane repolarization during SA node cell action potential; • regulation of heart rate by cardiac conduction; • positive regulation of G1/S transition of mitotic cell cycle; • positive regulation of myoblast proliferation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;