Kv1.4カリウムチャネル
WordNet
- direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
- a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
- a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
- (often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
- a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
- a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
- street names for ketamine (同)jet, super acid, special K, honey oil, green, cat valium, super C
- the 11th letter of the Roman alphabet (同)k
- a light soft silver-white metallic element of the alkali metal group; oxidizes rapidly in air and reacts violently with water; is abundant in nature in combined forms occurring in sea water and in carnallite and kainite and sylvite (同)K, atomic number 19
- official routes of communication; "you have to go through channels"
PrepTutorEJDIC
- 〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
- Kelvin / Kindergarten / (チェスの)King / kalium(ラテン語)(=potassium)の化学記号
- ポタシウム,カリウム(金属元素;化学記号はK)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/19 18:28:50」(JST)
[Wiki en表示]
| Potassium voltage-gated channel, shaker-related subfamily, member 4 |
PDB rendering based on 1kn7. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1kn7, 1zto
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| Identifiers |
| Symbols |
KCNA4 ; HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; PCN2 |
| External IDs |
OMIM: 176266 MGI: 96661 HomoloGene: 20514 IUPHAR: Kv1.4 ChEMBL: 4205 GeneCards: KCNA4 Gene |
| Gene ontology |
| Molecular function |
• voltage-gated potassium channel activity
• delayed rectifier potassium channel activity
• protein binding
• potassium ion binding
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| Cellular component |
• plasma membrane
• voltage-gated potassium channel complex
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| Biological process |
• potassium ion transport
• synaptic transmission
• regulation of ion transmembrane transport
• protein homooligomerization
• potassium ion transmembrane transport
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
3739 |
16492 |
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| Ensembl |
ENSG00000182255 |
ENSMUSG00000042604 |
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| UniProt |
P22459 |
Q61423 |
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| RefSeq (mRNA) |
NM_002233 |
NM_021275 |
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| RefSeq (protein) |
NP_002224 |
NP_067250 |
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| Location (UCSC) |
Chr 11:
30.03 – 30.04 Mb |
Chr 2:
107.29 – 107.3 Mb |
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| PubMed search |
[1] |
[2] |
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| Potassium channel Kv1.4 tandem inactivation domain |
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solution structure of the tandem inactivation domain (residues 1-75) of potassium channel rck4 (kv1.4)
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| Identifiers |
| Symbol |
K_channel_TID |
| Pfam |
PF07941 |
| InterPro |
IPR012897 |
| SCOP |
1kn7 |
| SUPERFAMILY |
1kn7 |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
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Potassium voltage-gated channel subfamily A member 4 also known as Kv1.4 is a protein that in humans is encoded by the KCNA4 gene.[1][2][3] It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.[4]
Contents
- 1 Description
- 2 Interactions
- 3 See also
- 4 References
- 5 Further reading
- 6 External links
Description
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1 in humans.[3]
KCNA4 (Kv1.4) contains a tandem inactivation domain at the N terminus. It is composed of two subdomains. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway, as is the case with a classical ball domain. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that probably serves to attach ID1 to the cytoplasmic face of the channel. In this way, it can promote rapid access of ID1 to the receptor site in the open channel. ID1 and ID2 function together to bring about fast inactivation of the Kv1.4 channel, which is important for the role of the channel in short-term plasticity.[5]
Interactions
KCNA4 has been shown to interact with DLG4,[6][7][8][9] KCNA2[10] and DLG1.[6][8][11]
See also
- Voltage-gated potassium channel
- Voltage-gated potassium-channel Kv1.4 IRES
References
- ^ Philipson LH, Schaefer K, LaMendola J, Bell GI, Steiner DF (Feb 1991). "Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4". Nucleic Acids Res 18 (23): 7160. doi:10.1093/nar/18.23.7160. PMC 332806. PMID 2263489.
- ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
- ^ a b "Entrez Gene: KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4".
- ^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.
- ^ Wissmann R, Bildl W, Oliver D, Beyermann M, Kalbitzer HR, Bentrop D, Fakler B (May 2003). "Solution structure and function of the "tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4". J. Biol. Chem. 278 (18): 16142–50. doi:10.1074/jbc.M210191200. PMID 12590144.
- ^ a b Inanobe, Atsushi; Fujita Akikazu; Ito Minoru; Tomoike Hitonobu; Inageda Kiyoshi; Kurachi Yoshihisa (Jun 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. (United States) 282 (6): C1396–403. doi:10.1152/ajpcell.00615.2001. ISSN 0363-6143. PMID 11997254.
- ^ Niethammer, M; Valtschanoff J G; Kapoor T M; Allison D W; Weinberg R J; Craig A M; Sheng M (Apr 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron (UNITED STATES) 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. ISSN 0896-6273. PMID 9581762.
- ^ a b Kim, E; Sheng M (1996). "Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases". Neuropharmacology (ENGLAND) 35 (7): 993–1000. doi:10.1016/0028-3908(96)00093-7. ISSN 0028-3908. PMID 8938729.
- ^ Eldstrom, Jodene; Doerksen Kyle W; Steele David F; Fedida David (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Lett. (Netherlands) 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. ISSN 0014-5793. PMID 12435606.
- ^ Coleman, S K; Newcombe J; Pryke J; Dolly J O (Aug 1999). "Subunit composition of Kv1 channels in human CNS". J. Neurochem. (UNITED STATES) 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. ISSN 0022-3042. PMID 10428084.
- ^ Eldstrom, Jodene; Choi Woo Sung; Steele David F; Fedida David (Jul 2003). "SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism". FEBS Lett. (Netherlands) 547 (1–3): 205–11. doi:10.1016/S0014-5793(03)00668-9. ISSN 0014-5793. PMID 12860415.
Further reading
- Scott HS, Litjens T, Hopwood JJ, Morris CP (1993). "PCR detection of two RFLPs in exon I of the alpha-L-iduronidase (IDUA) gene.". Hum. Genet. 90 (3): 327. doi:10.1007/bf00220095. PMID 1362562.
- Gessler M, Grupe A, Grzeschik KH, Pongs O (1993). "The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene.". Hum. Genet. 90 (3): 319–21. doi:10.1007/bf00220091. PMID 1487251.
- Philipson LH, Hice RE, Schaefer K, et al. (1991). "Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.". Proc. Natl. Acad. Sci. U.S.A. 88 (1): 53–7. doi:10.1073/pnas.88.1.53. PMC 50746. PMID 1986382.
- Tamkun MM, Knoth KM, Walbridge JA, et al. (1991). "Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle.". FASEB J. 5 (3): 331–7. PMID 2001794.
- Kim E, Niethammer M, Rothschild A, et al. (1995). "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.". Nature 378 (6552): 85–8. doi:10.1038/378085a0. PMID 7477295.
- Klocke R, Roberds SL, Tamkun MM, et al. (1994). "Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.". Genomics 18 (3): 568–74. doi:10.1016/S0888-7543(05)80358-1. PMID 7905852.
- Philipson LH, Eddy RL, Shows TB, Bell GI (1993). "Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4→q14.1.". Genomics 15 (2): 463–4. doi:10.1006/geno.1993.1094. PMID 8449523.
- Niethammer M, Kim E, Sheng M (1996). "Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases.". J. Neurosci. 16 (7): 2157–63. PMID 8601796.
- Kim E, Sheng M (1997). "Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases.". Neuropharmacology 35 (7): 993–1000. doi:10.1016/0028-3908(96)00093-7. PMID 8938729.
- Kim E, Naisbitt S, Hsueh YP, et al. (1997). "GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules.". J. Cell Biol. 136 (3): 669–78. doi:10.1083/jcb.136.3.669. PMC 2134290. PMID 9024696.
- Niethammer M, Valtschanoff JG, Kapoor TM, et al. (1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.". Neuron 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762.
- Brenman JE, Topinka JR, Cooper EC, et al. (1998). "Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A.". J. Neurosci. 18 (21): 8805–13. PMID 9786987.
- Coleman SK, Newcombe J, Pryke J, Dolly JO (1999). "Subunit composition of Kv1 channels in human CNS.". J. Neurochem. 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084.
- D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M (1999). "Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function.". FASEB J. 13 (11): 1335–45. PMID 10428758.
- Hogan A, Shepherd L, Chabot J, et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.". J. Biol. Chem. 276 (28): 26526–33. doi:10.1074/jbc.M104156200. PMID 11352924.
- Cukovic D, Lu GW, Wible B, et al. (2001). "A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2.". FEBS Lett. 498 (1): 87–92. doi:10.1016/S0014-5793(01)02505-4. PMID 11389904.
- Imamura F, Maeda S, Doi T, Fujiyoshi Y (2002). "Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel.". J. Biol. Chem. 277 (5): 3640–6. doi:10.1074/jbc.M106940200. PMID 11723117.
- Piserchio A, Pellegrini M, Mehta S, et al. (2002). "The PDZ1 domain of SAP90. Characterization of structure and binding.". J. Biol. Chem. 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.
External links
- Kv1.4 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
- KCNA4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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PDB gallery
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1kn7: Solution structure of the tandem inactivation domain (residues 1-75) of potassium channel RCK4 (Kv1.4)
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1zto: INACTIVATION GATE OF POTASSIUM CHANNEL RCK4, NMR, 8 STRUCTURES
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Membrane transport protein: ion channels (TC 1A)
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Ca2+: Calcium channel
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| Ligand-gated |
- Inositol trisphosphate receptor
- Ryanodine receptor
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| Voltage-gated |
- L-type/Cavα
- N-type/Cavα2.2
- P-type/Cavα
- Q-type/Cavα2.1
- R-type/Cavα2.3
- T-type/Cavα
- α2δ-subunits
- β-subunits
- γ-subunits
- Cation channels of sperm
- Two-pore channel
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Na+: Sodium channel
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| Constitutively active |
- Epithelial sodium channel
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| Proton-gated |
- Amiloride-sensitive cation channel
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| Voltage-gated |
- Navα
- 1.1
- 1.2
- 1.3
- 1.4
- 1.5
- 1.6
- 1.7
- 1.8
- 1.9
- 7A
- Navβ
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K+: Potassium channel
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| Calcium-activated |
- BK channel
- SK channel
- IK channel
- KCa
- 1.1
- 2.1
- 2.2
- 2.3
- 3.1
- 4.1
- 4.2
- 5.1
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| Inward-rectifier |
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| Tandem pore domain |
- K2P
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 9
- 10
- 12
- 13
- 15
- 16
- 17
- 18
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| Voltage-gated |
- Kvα1-6
- 1.1
- 1.2
- 1.3
- 1.4
- 1.5
- 1.6
- 1.7
- 1.8
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- Kvβ
- KCNIP
- minK/ISK
- minK/ISK-like
- MiRP
- Shaker gene
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Miscellaneous
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| Cl-: Chloride channel |
- Calcium-activated chloride channels
- Anoctamin
- Bestrophin
- Chloride Channel Accessory
- CFTR
- CLCN
- CLIC
- CLNS
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| H+: Proton channel |
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| M+: CNG cation channel |
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| M+: TRP cation channel |
- TRPA (1)
- TRPC
- TRPM
- TRPML
- TRPN
- TRPP
- TRPV
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| H2O (+ solutes): Porin |
- Aquaporin
- Voltage-dependent anion channel
- General bacterial porin family
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| Cytoplasm: Gap junction |
- Connexin: A
- GJA1
- GJA3
- GJA4
- GJA5
- GJA8
- GJA9
- GJA10
- B
- GJB1
- GJB2
- GJB3
- GJB4
- GJB5
- GJB6
- GJB7
- C
- D
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By gating mechanism
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| Ion channel class |
- Ligand-gated
- Light-gated
- Voltage-gated
- Stretch-activated
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see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article incorporates text from the public domain Pfam and InterPro IPR012897
UpToDate Contents
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English Journal
- Increase in the titer of lentiviral vectors expressing potassium channels by current blockade during viral vector production.
- Okada M1, Andharia N2, Matsuda H3.
- BMC neuroscience.BMC Neurosci.2015 May 5;16:30. doi: 10.1186/s12868-015-0159-1.
- BACKGROUND: High titers of lentiviral vectors are required for the efficient transduction of a gene of interest. During preparation of lentiviral the vectors, the protein of interest is inevitably expressed in the viral vector-producing cells. This expression may affect the production of the lentivi
- PMID 25940378
- Inhalational anesthetics disrupt postsynaptic density protein-95, Drosophila disc large tumor suppressor, and zonula occludens-1 domain protein interactions critical to action of several excitatory receptor channels related to anesthesia.
- Tao F1, Chen Q, Sato Y, Skinner J, Tang P, Johns RA.
- Anesthesiology.Anesthesiology.2015 Apr;122(4):776-86. doi: 10.1097/ALN.0000000000000609.
- BACKGROUND: The authors have shown previously that inhaled anesthetics disrupt the interaction between the second postsynaptic density protein-95, Drosophila disc large tumor suppressor, and zonula occludens-1 (PDZ) domain of postsynaptic density protein-95 (PSD-95) and the C-terminus of N-methyl-D-
- PMID 25654436
- The degree of N-glycosylation affects the trafficking and cell surface expression levels of Kv1.4 potassium channels.
- Watanabe I1, Zhu J, Recio-Pinto E, Thornhill WB.
- The Journal of membrane biology.J Membr Biol.2015 Apr;248(2):187-96. doi: 10.1007/s00232-014-9756-7. Epub 2014 Nov 22.
- Kv1.4 potassium channels are heavily glycosylated proteins involved in shaping action potentials and in neuronal excitability and plasticity. Kv1.4 N354Q, without an N-glycan, exhibited decreased protein stability and trafficking to the cell surface (Watanabe et al. in J Biol Chem 279:8879-8885, 200
- PMID 25416425
Japanese Journal
- 重症筋無力症における味覚障害と抗電位依存性カリウムチャンネル(Kv)1.4抗体
- 蒲澤 千昌,清水 優子,鈴木 重明 [他],内山 真一郎,KABASAWA Chiaki,SHIMIZU Yuko,SUZUKI Shigeaki,UCHIYAMA Shinichiro
- 東京女子医科大学雑誌 83(4), 242-248, 2013-08-25
- … 緒言:近年、重症筋無力症(MG)患者に新規抗体が報告され、その一つである抗電位依存性カリウムチャンネル(Kv)1.4抗体陽性のMG患者では重症度と相関すると言われている.MGの非運動性障害の一つに味覚障害が報告されているが、有症率や発症機序は不明である.今回、多施設共同研究によりMGの味覚障害を検討した. …
- NAID 110009610660
- New clinical entity of myasthenia gravis with autoimmune targets of heart and skeletal muscles
- 鈴木 重明
- 臨床神経学 52(11), 1312-1314, 2012
- … All patients showed severe symptoms with bulbar involvement accompanied by myasthenic crisis in 5 and invasive thymoma in 4. … Seven patients had one of these anti-striational autoantibodies (those to titin, ryanodine receptor, muscular voltage-gated potassium channel, Kv1.4). …
- NAID 130004505145
- The Effects of Ginsenoside Rg_3 on Human Kv1.4 Channel Currents without the N-Terminal Rapid Inactivation Domain(Pharmacology)
- Lee Jun-Ho,Choi Sun-Hye,Lee Byung-Hwan [他],SHIN Tae-Joon,PYO Mi Kyung,HWANG Sung-Hee,KIM Bo-Ra,LEE Sang-Mok,BAE Dong-Ho,RHIM Hyewhon,NAH Seung-Yeol
- Biological & pharmaceutical bulletin 32(4), 614-618, 2009-04-01
- … Kv1.4 channel belongs to the family of voltage-gated potassium channels that mediate transient and rapidly inactivating A-type currents and N-type inactivation. …
- NAID 110007160693
Related Links
- Kv1.4 (encoded by the gene KCNA4), a prominent member of the Kv1 family, is a fast inactivation A-type Kv channel which is widely distributed in the central nervous system, where it is concentrated in axonal membranes or near ...
- Potassium channels are the most diverse group of the ion channel family [PMID: 1772658, PMID: 1879548]. They are important in shaping the action potential, and in neuronal excitability and plasticity [PMID: 2451788].
Related Pictures
★リンクテーブル★
[★]
- 英
- Kv1.4 potassium channel
[★]
- 川床、川底。水路、河道
- 海峡
- 水管、導管
- 溝
- 経路、ルート。道筋、方向
- 関
- ion channel、ionic channel
[★]