WordNet

direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
street names for ketamine (同)jet, super acid, special K, honey oil, green, cat valium, super C
the 11th letter of the Roman alphabet (同)k
a light soft silver-white metallic element of the alkali metal group; oxidizes rapidly in air and reacts violently with water; is abundant in nature in combined forms occurring in sea water and in carnallite and kainite and sylvite (同)K, atomic number 19
official routes of communication; "you have to go through channels"

PrepTutorEJDIC

〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
Kelvin / Kindergarten / (チェスの)King / kalium(ラテン語)(=potassium)の化学記号
ポタシウム,カリウム(金属元素;化学記号はK)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/30 21:59:50」(JST)

wiki en

Potassium voltage-gated channel subfamily A member 2 also known as K_v1.2 is a protein that in humans is encoded by the KCNA2 gene.^[1]^[2]

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.^[2]

Interactions

KCNA2 has been shown to interact with KCNA4,^[3] DLG4,^[4] PTPRA,^[5] KCNAB2,^[3]^[6] RHOA^[7] and Cortactin.^[8]

References

^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
^ ^a ^b "Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2".
^ ^a ^b Coleman, S K; Newcombe J; Pryke J; Dolly J O (Aug 1999). "Subunit composition of Kv1 channels in human CNS". J. Neurochem. (UNITED STATES) 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. ISSN 0022-3042. PMID 10428084.
^ Eldstrom, Jodene; Doerksen Kyle W; Steele David F; Fedida David (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Lett. (Netherlands) 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. ISSN 0014-5793. PMID 12435606.
^ Tsai, W; Morielli A D; Cachero T G; Peralta E G (Jan 1999). "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity". EMBO J. (ENGLAND) 18 (1): 109–18. doi:10.1093/emboj/18.1.109. ISSN 0261-4189. PMC 1171107. PMID 9878055.
^ Nakahira, K; Shi G; Rhodes K J; Trimmer J S (Mar 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". J. Biol. Chem. (UNITED STATES) 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. ISSN 0021-9258. PMID 8636142.
^ Cachero, T G; Morielli A D; Peralta E G (Jun 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel". Cell (UNITED STATES) 93 (6): 1077–85. doi:10.1016/S0092-8674(00)81212-X. ISSN 0092-8674. PMID 9635436.
^ Hattan, David; Nesti Edmund; Cachero Teresa G; Morielli Anthony D (Oct 2002). "Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". J. Biol. Chem. (United States) 277 (41): 38596–606. doi:10.1074/jbc.M205005200. ISSN 0021-9258. PMID 12151401.

External links

Kv1.2 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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English Journal

Subunit-Dependent Axonal Trafficking of Distinct {alpha} Heteromeric Potassium Channel Complexes.

Jenkins PM, McIntyre JC, Zhang L, Anantharam A, Vesely ED, Arendt KL, Carruthers CJ, Kerppola TK, Iniguez-Lluhi JA, Holz RW, Sutton MA, Martens JR.SourceDepartments of Pharmacology, Molecular and Integrative Physiology, and Biological Chemistry, Molecular and Behavioral Neuroscience Institute, and Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2011 Sep 14;31(37):13224-35.
Voltage-gated potassium (Kv) channels are critical for neuronal excitability and are targeted to specific subcellular compartments to carry out their unique functions. While it is widely believed that Kv channels exist as heteromeric complexes in neurons, direct tests of the hypothesis that specific
PMID 21917805

Charybdotoxin Unbinding from the mKv1.3 Potassium Channel: A Combined Computational and Experimental Study.

Khabiri M, Nikouee A, Cwiklik L, Grissmer S, Ettrich R.SourceInstitute of Nanobiology and Structural Biology of GCRC, Academy of Sciences of the Czech Republic , and Faculty of Sciences, University of South Bohemia in Ceske Budejovice , Zamek 136, CZ-373 33 Nove Hrady, Czech Republic.
The journal of physical chemistry. B.J Phys Chem B.2011 Sep 13. [Epub ahead of print]
Charybdotoxin, belonging to the group of so-called scorpion toxins, is a short peptide able to block many voltage-gated potassium channels, such as mKv1.3, with high affinity. We use a reliable homology model based on the high-resolution crystal structure of the 94% sequence identical homologue Kv1.
PMID 21877740

Japanese Journal

動脈管におけるATP感受性カリウムチャンネル,膜電位依存性カリウムチャンネルの発現

呉翆嬌
東京女子医科大学雑誌 76(5/6), 212-218, 2006-06
… The ATP-sensitive potassium (K_<ATP>) channel may contribute to determination of the membrane potential in smooth muscle cells of the ductus arteriosus (DA) and, thus, to regulation of contractile tone in response to oxygen. … Oxygen-sensitive, voltage-gated potassium channels (Kv) may also be important in the regulation of ductal tone. …
NAID 110007525449

Different Gene Expression of Potassium Channels by Thyroid Hormone and an Antithyroid Drug Between the Atrium and Ventricle of Rats

Ma Mei Lei,Watanabe Kenichi,Watanabe Hiroshi,Hosaka Yukio,Komura Satoru,Aizawa Yoshifusa,Yamamoto Tadashi
Japanese Heart Journal 44(1), 101-110, 2003
… Thyroid hormone has been shown to modulate the gene expression of cardiac potassium channels, however, it is not known if gene expression is different between the atrium and the ventricle. … The levels of mRNA of Kv1.2, Kv1.4, Kv1.5, Kv2.1, Kv4.2, erg, LQT1, and minK were assayed by RNase protection assay. …
NAID 130000067390

Related Pictures

★リンクテーブル★

リンク元	「Kv1.2カリウムチャネル」
関連記事	「channel」「K」

「Kv1.2カリウムチャネル」

Potassium channel, voltage gated shaker related subfamily A, member 2
	PDB rendering based on 1dsx.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1dsx, 1exb, 1qdv, 1qdw, 2a79
Identifiers
Symbols	KCNA2 ; EIEE32; HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2
External IDs	OMIM: 176262 MGI: 96659 HomoloGene: 21034 IUPHAR: 539 ChEMBL: 2086 GeneCards: KCNA2 Gene
Gene ontology
Molecular function	• voltage-gated potassium channel activity; • delayed rectifier potassium channel activity; • potassium channel activity; • protein binding; • outward rectifier potassium channel activity;
Cellular component	• endoplasmic reticulum membrane; • plasma membrane; • integral component of plasma membrane; • voltage-gated potassium channel complex; • lamellipodium; • cell junction; • axon; • dendrite; • lamellipodium membrane; • neuronal cell body membrane; • presynaptic membrane; • perikaryon; • axon terminus; • juxtaparanode region of axon;
Biological process	• potassium ion transport; • synaptic transmission; • regulation of dopamine secretion; • neuronal action potential; • sensory perception of pain; • optic nerve structural organization; • regulation of ion transmembrane transport; • regulation of circadian sleep/wake cycle, non-REM sleep; • protein homooligomerization; • potassium ion transmembrane transport;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;