- 関
- IGF-binding protein、insulin-like growth factor binding protein
- 関
- IGF binding protein
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/18 06:00:01」(JST)
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Insulin-like growth factor
binding protein |
|
Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5).[1]
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| Identifiers |
| Symbol |
IGFBP |
| Pfam |
PF00219 |
| InterPro |
IPR000867 |
| SMART |
SM00121 |
| PROSITE |
PDOC00194 |
| SCOP |
1boe |
| SUPERFAMILY |
1boe |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1 (IGF-1).[2]
Contents
- 1 Function
- 2 Family members
- 3 See also
- 4 References
- 5 External links
Function
Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1.
IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR.[3]
The IGFBPs help to lengthen the half-life of circulating IGFs in all tissues, including the prostate.[4] Individual IGFBPs may act to enhance or attenuate IGF signaling depending on their physiological context (i.e. cell type). Even with these similarities, some characteristics are different: chromosomal location, heparin binding domains, RGD recognition site, preference for binding IGF-I or IGF-II, and glycosylation and phosphorylation differences.[5] These structural differences can have a tremendous impact on how the IGFBPs interact with cellular basement membranes.
Family members
In humans, IGFBPs are transcribed from the following seven genes:
- IGFBP1
- IGFBP2
- IGFBP3
- IGFBP4
- IGFBP5
- IGFBP6
- IGFBP7
See also
- Insulin-like growth factor receptor
References
- ^ Kalus W, Zweckstetter M, Renner C, et al. (November 1998). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions". EMBO J. 17 (22): 6558–72. doi:10.1093/emboj/17.22.6558. PMC 1171003. PMID 9822601.
- ^ Hwa V, Oh Y, Rosenfeld RG (December 1999). "The insulin-like growth factor-binding protein (IGFBP) superfamily". Endocr. Rev. 20 (6): 761–87. doi:10.1210/er.20.6.761. PMID 10605625.
- ^ Clemmons DR, Busby WH, Arai T, Nam TJ, Clarke JB, Jones JI, Ankrapp DK (1995). "Role of insulin-like growth factor binding proteins in the control of IGF actions". Prog. Growth Factor Res. 6 (2–4): 357–66. doi:10.1016/0955-2235(95)00013-5. PMID 8817679.
- ^ Stewart CE, Bates PC, Calder TA, Woodall SM, Pell JM (September 1993). "Potentiation of insulin-like growth factor-I (IGF-I) activity by an antibody: supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins". Endocrinology 133 (3): 1462–5. doi:10.1210/en.133.3.1462. PMID 7689959.
- ^ Gregory CW, DeGeorges A, Sikes RA (2001). "The IGF axis in the development and progression of prostate cancer". Recent Research Developments in Cancer: 437–462. ISBN 81-7895-002-2.
External links
- Insulin-like growth factor binding proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
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Proteins: carrier proteins
|
|
| Fatty acid |
- FABP1
- FABP2
- FABP3
- FABP4
- FABP5
- FABP6
- FABP7
|
|
| Hormone |
- peptide hormone: Follistatin
- Growth hormone binding protein
- Insulin-like growth factor binding protein
- IGFBP1
- IGFBP2
- IGFBP3
- IGFBP4
- IGFBP5
- IGFBP6
- IGFBP7
- Neurophysins
- steroid hormone: Sex hormone binding globulin/Androgen binding protein
- Transcortin
- Thyroxine-binding globulin
- Transthyretin
|
|
| Metal/element |
- calcium
- Calcium-binding protein
- Calmodulin-binding proteins
- copper
- iron
- Iron-binding proteins
- Transferrin receptor
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|
| Vitamin |
- Retinol binding protein
- Transcobalamin
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|
| Pigment |
- Plant Light-Harvesting Complex
- Orange Carotenoid Protein
- Phycobiliprotein
- Photosynthetic Reaction Centers
- Phytochrome
- Rhodopsin
|
|
| Other |
- Acyl carrier protein
- Adaptor protein
- Cholesterylester transfer protein
- F-box protein
- GTP-binding protein
- Latent TGF-beta binding protein
- Major urinary proteins
- Membrane transport protein
- Odorant binding protein
|
|
UpToDate Contents
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English Journal
- Insulin-like growth factor binding protein-2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis.
- Ding H1, Kharboutli M1, Saxena R2, Wu T1.
- Clinical and experimental immunology.Clin Exp Immunol.2016 Apr;184(1):11-8. doi: 10.1111/cei.12743. Epub 2016 Jan 11.
- Lupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus. Invasive renal biopsy remains the gold standard for the diagnosis and management of LN. The objective of this study is to validate serum insulin-like growth factor binding protein-2 (IGFBP-2) as a novel b
- PMID 26616478
- Cord IGF-I concentrations in Indian newborns: associations with neonatal body composition and maternal determinants.
- Wiley AS1, Lubree HG2, Joshi SM2, Bhat DS2, Ramdas LV2, Rao AS2, Thuse NV2, Deshpande VU2, Yajnik CS2.
- Pediatric obesity.Pediatr Obes.2016 Apr;11(2):151-7. doi: 10.1111/ijpo.12038. Epub 2015 May 8.
- BACKGROUND: Indian newborns have been described as 'thin-fat' compared with European babies, but little is known about how this phenotype relates to the foetal growth factor IGF-I (insulin-like growth factor I) or its binding protein IGFBP-3.OBJECTIVE: To assess cord IGF-I and IGFBP-3 concentrations
- PMID 25955285
- Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3.
- Kartal Ö1,2, Aydınöz S2, Kartal AT1,3, Kelestemur T1, Caglayan AB1, Beker MC1, Karademir F2, Süleymanoğlu S2, Kul M2, Yulug B1, Kilic E4.
- Metabolic brain disease.Metab Brain Dis.2016 Mar 4. [Epub ahead of print]
- Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturban
- PMID 26943480
Japanese Journal
- 乳がん細胞株におけるビタミンB_6の遺伝子発現調節作用
- 叶内 宏明,岡 達三
- ビタミン 86(8), 425-431, 2012-08-25
- … On the other hand, Insulin-like growth factor-binding protein-3 (IGFBP-3) is one of genes up-regulated by B_6. … The induction of IGFBP by B_6 could be inhibited by a specific p53 inhibitor, pifithrin-α. …
- NAID 110009489785
- 早産に関連した臨床検査 (今月の主題 周産期の臨床検査)
Related Links
- インスリン様成長因子結合蛋白3型, IGFBP‐3（insulin-like growth factor binding protein-3) 試薬販売中止のため（平成24年3月30日まで） 測定法： RIA-2 抗体法 IRMA法(固相法）平成17年3月25日まで 外注会社 ...
- 日本生殖内分泌学会雑誌（2006）11：21-25 21 研究フロンティア はじめに Insulin-like growth factor-I（IGF-I）結合蛋白質 （IGFBP）は，体液中のIGFが高分子複合体として存在 することからIGFに結合する蛋白質として同定された分 子 ...
Related Pictures
★リンクテーブル★
[★]
- 英
- insulin-like growth factor binding protein、IGFBP
- 関
- インスリン様成長因子結合蛋白質、インスリン様成長因子結合蛋白、インスリン様成長因子結合タンパク、インスリン様増殖因子結合タンパク質、IGF結合タンパク質
[★]
- 英
- insulin-like growth factor binding protein, IGFBP
- 関
- インスリン様成長因子結合タンパク質, インスリン様成長因子結合蛋白質, インスリン様成長因子結合蛋白, インスリン様成長因子結合タンパク
- 関
- IGF binding protein
[★]
- 関
- IGFBP、insulin-like growth factor binding protein
[★]
- 関
- insulin-like growth factor binding protein 3
- 同
- insulin-like growth factor binding protein-3
[★]
- 関
- insulin-like growth factor binding protein 2
[★]
- 関
- insulin-like growth factor binding protein 5
[★]
- 関
- insulin-like growth factor binding protein 6
[★]