WordNet
- an impairment of health or a condition of abnormal functioning
- a series with a definite pattern of advance (同)patterned advance
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
- the 8th letter of the Roman alphabet (同)h
- infection by the human immunodeficiency virus
PrepTutorEJDIC
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- 〈U〉前進,進行;進歩,進展 / 〈U〉(でき事などの)連続,連鎖 / 〈C〉数列
- 病気にかかった / 病的な,不健全な(morbid)
- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
UpToDate Contents
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- 1. HIVの進行に影響を与える因子 factors affecting hiv progression
- 2. 青年および成人におけるHIV感染の自然経過および臨床的特徴 the natural history and clinical features of hiv infection in adults and adolescents
- 3. HIV感染およびAIDSの神経精神学的側面の概要 overview of the neuropsychiatric aspects of hiv infection and aids
- 4. Pediatric HIV infection: Classification, clinical manifestations, and outcome
- 5. HIV感染患者における心血管疾患の病因およびバイオマーカー pathogenesis and biomarkers of cardiovascular disease in hiv infected patients
English Journal
- Progression of anal high-grade squamous intraepithelial lesions to invasive anal cancer among HIV-infected men who have sex with men.
- Berry JM, Jay N, Cranston RD, Darragh TM, Holly EA, Welton ML, Palefsky JM.Author information Department of Medicine, University of California San Francisco, San Francisco, CA.AbstractThe incidence of anal cancer is elevated in human immunodeficiency virus (HIV)-infected men-who-have-sex-with-men (MSM) compared to the general population. Anal high-grade squamous intraepithelial lesions (HSIL) are common in HIV-infected MSM and the presumed precursors to anal squamous cell cancer; however, direct progression of HSIL to anal cancer has not been previously demonstrated. The medical records were reviewed of 138 HIV-infected MSM followed up at the University of California, San Francisco, who developed anal canal or perianal squamous cancer between 1997 and 2011. Men were followed up regularly with digital anorectal examination (DARE), high-resolution anoscopy (HRA) and HRA-guided biopsy. Although treatment for HSIL and follow-up were recommended, not all were treated and some were lost to follow-up. Prevalent cancer was found in 66 men. Seventy-two HIV-infected MSM developed anal cancer while under observation. In 27 men, anal cancer developed at a previously biopsied site of HSIL. An additional 45 men were not analyzed in this analysis due to inadequate documentation of HSIL in relation to cancer location. Of the 27 men with documented progression to cancer at the site of biopsy-proven HSIL, 20 men progressed from prevalent HSIL identified when first examined and seven men from incident HSIL. Prevalent HSIL progressed to cancer over an average of 57 months compared to 64 months for incident HSIL. Most men were asymptomatic, and cancers were detected by DARE. Anal HSIL has clear potential to progress to anal cancer in HIV-infected MSM. Early diagnosis is facilitated by careful follow-up. Carefully controlled studies evaluating efficacy of screening for and treatment of HSIL to prevent anal cancer are needed.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 1;134(5):1147-55. doi: 10.1002/ijc.28431. Epub 2013 Sep 14.
- The incidence of anal cancer is elevated in human immunodeficiency virus (HIV)-infected men-who-have-sex-with-men (MSM) compared to the general population. Anal high-grade squamous intraepithelial lesions (HSIL) are common in HIV-infected MSM and the presumed precursors to anal squamous cell cancer;
- PMID 23934991
- Human T cell leukaemia virus type 2 tax protein mediates CC-chemokine expression in peripheral blood mononuclear cells via the nuclear factor kappa B canonical pathway.
- Barrios CS, Castillo L, Zhi H, Giam CZ, Beilke MA.Author information Infectious Diseases Division, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA; Research Service 151-I, Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA.AbstractRetroviral co-infections with human immunodeficiency virus type-1 (HIV-1) and human T cell leukaemia virus type 1 (HTLV-1) or type 2 (HTLV-2) are prevalent in many areas worldwide. It has been observed that HIV-1/HTLV-2 co-infections are associated with slower rates of CD4(+) T cell decline and delayed progression to AIDS. This immunological benefit has been linked to the ability of Tax2, the transcriptional activating protein of HTLV-2, to induce the expression of macrophage inflammatory protein (MIP)-1α/CCL3, MIP-1β/CCL4 and regulated upon activation normal T cell expressed and secreted (RANTES)/CCL5 and to down-regulate the expression of the CCR5 co-receptor in peripheral blood mononuclear cells (PBMCs). This study aimed to assess the role of Tax2-mediated activation of the nuclear factor kappa B (NF-κB) signalling pathway on the production of the anti-viral CC-chemokines MIP-1α, MIP-1β and RANTES. Recombinant Tax1 and Tax2 proteins, or proteins expressed via adenoviral vectors used to infect cells, were tested for their ability to activate the NF-κB pathway in cultured PBMCs in the presence or absence of NF-κB pathway inhibitors. Results showed a significant release of MIP-1α, MIP-1β and RANTES by PBMCs after the activation of p65/RelA and p50. The secretion of these CC-chemokines was significantly reduced (P < 0·05) by canonical NF-κB signalling inhibitors. In conclusion, Tax2 protein may promote innate anti-viral immune responses through the activation of the canonical NF-κB pathway.
- Clinical and experimental immunology.Clin Exp Immunol.2014 Jan;175(1):92-103. doi: 10.1111/cei.12213.
- Retroviral co-infections with human immunodeficiency virus type-1 (HIV-1) and human T cell leukaemia virus type 1 (HTLV-1) or type 2 (HTLV-2) are prevalent in many areas worldwide. It has been observed that HIV-1/HTLV-2 co-infections are associated with slower rates of CD4(+) T cell decline and dela
- PMID 24116893
- Kidney transplantation in HIV-positive adults: the UK experience.
- Gathogo EN, Hamzah L, Hilton R, Marshall N, Ashley C, Harber M, Levy JB, Jones R, Boffito M, Khoo SH, Drage M, Bhagani S, Post FA; UK HIV/Kidney Transplantation Study Group (see appendix).Author information King's College London, London, UK.AbstractHIV-positive patients are at increased risk of end-stage kidney disease (ESKD). Kidney transplantation (KT) is an established treatment modality for ESKD in the general population. Recent data have confirmed the feasibility of kidney transplantation in HIV-positive patients, and kidney transplantation is increasingly offered to ESKD patients with well-controlled HIV infection. We report clinical outcomes in a national cohort study of kidney transplantation in HIV-positive patients. In all, 35 HIV-positive KT recipients who had undergone KT up to December 2010 (66% male, 74% black ethnicity) were identified; the median CD4 cell count was 366, all had undetectable HIV RNA levels at kidney transplantation, and 44% received a kidney from a live donor. Patient survival at 1 and 3 years was 91.3%, and graft survival 91.3% and 84.7%, respectively. At one-year post-kidney transplantation, the cumulative incidence of acute rejection was 48%, and the median (IQR) eGFR was 64 (46, 78) mL/min/1.73 m(2). Although HIV viraemia and HIV disease progression were uncommon, renal complications were relatively frequent. Our study corroborates the feasibility of kidney transplantation in HIV-positive patients. The high rates of acute rejection suggest that the optimal immune suppression strategy in this population remains to be refined.
- International journal of STD & AIDS.Int J STD AIDS.2014 Jan;25(1):57-66. doi: 10.1177/0956462413493266. Epub 2013 Jul 19.
- HIV-positive patients are at increased risk of end-stage kidney disease (ESKD). Kidney transplantation (KT) is an established treatment modality for ESKD in the general population. Recent data have confirmed the feasibility of kidney transplantation in HIV-positive patients, and kidney transplantati
- PMID 23970634
Japanese Journal
- Evaluation of non-viral surrogate markers as predictive indicators for monitoring progression of HIV infection, Eight-year analysis in a regional center
- , , , , , , , ,
- Japanese Journal of Infectious Diseases advpub(0), 2015
- … Suitable methods for clinical monitoring of HIV-infected patients are very crucial in resource-poor setting areas. … Demographic data, clinical staging and laboratory findings for 112 HIV asymptomatic subjects were assessed at the first admission and the last visit from 2002 to 2010. … On Cox regression analysis, hemoglobin (Hb) (HR=0.643, p=0.021) was predictive indicator for disease progression, however; …
- NAID 130005069402
- Regulatory B cells correlate with HIV disease progression
- Jiao Yanmei,Wang Xi,Zhang Tong [他]
- Microbiology and immunology 58(8), 449–455, 2014-08
- NAID 40020164475
- Development of Primary Central Nervous System Lymphoma Associated with Human Immunodeficiency Virus and JC Virus Infection
- , , , , , , , , , , , , ,
- Journal of Clinical and Experimental Hematopathology 54(3), 211-217, 2014
- … We report here a case of a 37-year-old man with human immunodeficiency virus (HIV) infection followed by JC virus (JCV) infection and primary central nervous system lymphoma (PCNSL). … The patient had been infected with HIV type 1 due to blood products for hemophilia A during infancy. … He had progression of nervous symptoms and was diagnosed with progressive multifocal leukoencephalopathy (PML) clinically at the age of 36, when his CD4-positive lymphocyte counts ranged between 350 and 450/μl. …
- NAID 130004705268
Related Pictures
★リンクテーブル★
| リンク元 | 「HIV疾患進行」 |
| 関連記事 | 「disease」「progression」「HIV」「H」「disease progression」 |
「HIV疾患進行」
「disease」
- n.
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 注意
「progression」
- n.
- n.
- (～から/～への)進行、前進(progress)(from/to)
- 進歩、発達、発展(progress)
- (天文)(惑星の)順行
- 連続、継続(sequence)
- (数学)数列
「HIV」
[★] human immunodeficiency virus HIVウイルス ヒト免疫不全ウイルス
「H」