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1. ファブリー病の臨床的特徴および診断 clinical features and diagnosis of fabry disease
2. ファブリー病の治療 treatment of fabry disease
3. ファブリー病の神経症状 neurologic manifestations of fabry disease
4. 心疾患を伴うファブリー病の臨床的特徴、診断、およびマネージメント clinical features diagnosis and management of patients with fabry disease with cardiac disease
5. 腎臓学および高血圧の最新情報 whats new in nephrology and hypertension

Binding profiles and cytokine-inducing effects of fish rhamnose-binding lectins on Burkitt's lymphoma Raji cells.

Hosono M1, Sugawara S, Matsuda A, Tatsuta T, Koide Y, Hasan I, Ozeki Y, Nitta K.
Fish physiology and biochemistry.Fish Physiol Biochem.2014 Oct;40(5):1559-72. doi: 10.1007/s10695-014-9948-1. Epub 2014 May 27.
Rhamnose-binding lectin (RBL) is one of the animal lectin categories which take part in the innate immune responses of fish. Osmerus lanceolatus lectin (OLL) from shishamo smelt eggs is an RBL composed of two tandem-repeated domains, both of which are considered to be a carbohydrate-recognition doma
PMID 24861899

Using Hydrogen-Deuterium Exchange to Monitor Protein Structure in the Presence of Gold Nanoparticles.

Wang A, Vo T, Le VH, Fitzkee NC.
The journal of physical chemistry. B.J Phys Chem B.2014 Sep 29. [Epub ahead of print]
The potential applications of protein-functionalized gold nanoparticles (AuNPs) have motivated many studies characterizing protein-AuNP interactions. However, the lack of detailed structural information has hindered our ability to understand the mechanism of protein adsorption on AuNPs. In order to
PMID 25265213

Protein apparent dielectric constant and its temperature dependence from remote chemical shift effects.

An L1, Wang Y, Zhang N, Yan S, Bax A, Yao L.
Journal of the American Chemical Society.J Am Chem Soc.2014 Sep 17;136(37):12816-9. doi: 10.1021/ja505852b. Epub 2014 Sep 5.
A NMR protocol is introduced that permits accurate measurement of minute, remote chemical shift perturbations (CSPs), caused by a mutation-induced change in the electric field. Using protein GB3 as a model system, (1)H(N) CSPs in K19A and K19E mutants can be fitted to small changes in the electric f
PMID 25192058

Spontaneous Accumulation of Globotriaosylceramide (Gb3) in Proximal Renal Tubules in an ICR Mouse

Mutsuga Mayu,Asaoka Yoshiji,Togashi Yuko [他],Imura Naoko,Miyoshi Tomoya,Miyamoto Yohei
Journal of Toxicologic Pathology 26(4), 429-432, 2013
… These histopathological features are similar to those in α-galactosidase A-deficient mice, in which globotriaosylceramide (Gb3), a glycosphingolipid, accumulates in lysosomes. … When we performed immunohistochemical staining for Gb3, the contents of vacuoles were positively stained. … From these results, spontaneous cytoplasmic vacuolation in the proximal renal tubules in the mouse was identified as lysosomal accumulation of Gb3. …
NAID 130003382465

菅原栄紀,新谷香絵,細野雅祐 [他],立田岳生,仁田一雄
東北薬科大学研究誌 58, 41-46, 2011-12
… SAL also recognizes galactosylα-linked carbohydrate chains of not only glycoproteins but also glycosphingolipids, especially globotriaosylceramide(Gb3). … we studied whether SAL also enhances the cytotoxic effect of vinblastine and irinotecan in Gb3-expressing Raji or Gb3-negative K562 cells. …
NAID 110009512453