WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- a substance that retards or stops an activity
- restrictive of action; "a repressive regime"; "an overly strict and inhibiting discipline" (同)repressive, repressing
PrepTutorEJDIC
- 蛋白(たんばく)質
- 抑制する人(物) / 化学反応抑制剤
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- 1. プロテインC欠乏症：臨床症状および診断 protein c deficiency clinical manifestations and diagnosis
- 2. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
- 3. 幼児の食物蛋白誘発性直腸炎/大腸炎および腸疾患 food protein induced proctitis colitis and enteropathy of infancy
- 4. 第V因子ライデンおよび活性化プロテインC抵抗性：臨床症状および診断 factor v leiden and activated protein c resistance clinical manifestations and diagnosis
- 5. アポトーシスと自己免疫疾患 apoptosis and autoimmune disease
English Journal
- The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.
- Grunert M, Gottschalk K, Kapahnke J, Gündisch S, Kieser A, Jeremias I.SourceResearch Group Apoptosis, Department of Gene Vectors, Helmholtz Center Munich - German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany.
- Cell death & disease.Cell Death Dis.2012 Oct 25;3:e414. doi: 10.1038/cddis.2012.154.
- Besides inducing apoptosis, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates NF-κB. The apoptosis signaling pathway of TRAIL is well characterized involving TRAIL receptors, Fas-associated protein with death domain (FADD) and caspase-8. In contrast, the molecular mechanism
- PMID 23096115
- TNF signaling drives myeloid-derived suppressor cell accumulation.
- Zhao X, Rong L, Zhao X, Li X, Liu X, Deng J, Wu H, Xu X, Erben U, Wu P, Syrbe U, Sieper J, Qin Z.AbstractTNF, an inflammatory cytokine that is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. We previously reported that tumors implanted in TNF receptor-deficient (Tnfr-/-) mice are spontaneously rejected; however, the molecular mechanisms underlying this rejection are unclear. Here we report that TNF signaling drives the peripheral accumulation of myeloid-derived suppressor cells (MDSCs). MDSCs expand extensively during inflammation and tumor progression in mice and humans and can enhance tumor growth by repressing T cell-mediated antitumor responses. Peripheral accumulation of MDSCs was drastically impaired in Tnfr-/- mice. Signaling of TNFR-2, but not TNFR-1, promoted MDSC survival through upregulation of cellular FLICE-inhibitory protein (c-FLIP) and inhibition of caspase-8 activity. Loss of TNFRs impaired the induction of MDSCs from bone marrow cells, but this could be reversed by treatment with caspase inhibitors. These results demonstrate that TNFR-2 signaling promotes MDSC survival and accumulation and helps tumor cells evade the immune system.
- The Journal of clinical investigation.J Clin Invest.2012 Nov 1;122(11):4094-104. doi: 10.1172/JCI64115. Epub 2012 Oct 15.
- TNF, an inflammatory cytokine that is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. We previously reported that tumors implanted in TNF receptor-deficient (Tnfr-/-) mice are spontaneously rejected; however, the molecular mechanism
- PMID 23064360
Japanese Journal
- 抗アポトーシス因子・cellular FLICE-inhibitory protein (cFLIP)による哺乳類の卵胞選抜制御機構
- 松田 二子,眞鍋 昇
- 比較内分泌学 38(144), 27-32, 2012-02
- NAID 40019224514
- Implication of cytokines : Roles of tumor necrosis factor-α in liver injury
- NAGAKI Masahito,MORIWAKI Hisataka
- Hepatology research : the official journal of the Japan Society of Hepatology 38, 19, 2008-11-01
- NAID 10025323078
Related Links
- Caspase-eight-related protein; CASPER; Caspase homologue; CASH; Caspase-like apoptosis-regulatory protein; CLARP; Inhibitor of FLICE; I-FLICE; Fas-associated death domain; FADD-like antiapoptotic molecule 1; FLAME-1 ...
- The apoptosis cascade that plays a central role in normal and pathological processes is strictly controlled, in part by FLIP (Fas-associated death domain-like interleukin-1β-converting enzyme-inhibitory protein), an inhibitor of caspase ...
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★リンクテーブル★
| リンク元 | 「FLICE抑制タンパク質」「FLIP」「CASP8 and FADD-like apoptosis regulating protein」 |
| 関連記事 | 「inhibitor」「inhibitory」「inhibitory protein」「FLICE」 |
「FLICE抑制タンパク質」
-FLIP
「FLIP」
「CASP8 and FADD-like apoptosis regulating protein」
「inhibitor」
- n.
「inhibitory」
- 抑制性の、抑制的な、阻害性の