関: FLICE-inhibitory protein

WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animals survival (同)programmed_cell_death, caspase-mediated cell death
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
蛋白(たんばく)質
(…の)『好み』,趣味《+『for』(『to』)+『名』》

UpToDate Contents

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1. アポトーシスと自己免疫疾患 apoptosis and autoimmune disease
2. 糸球体の免疫障害の機序 mechanisms of immune injury of the glomerulus
3. 多発性骨髄腫の病理生物学 pathobiology of multiple myeloma
4. 前立腺癌の分子生物学 molecular biology of prostate cancer
5. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia

English Journal

BIN1 tumor suppressor regulates Fas/Fas ligand-mediated apoptosis through c-FLIP in cutaneous T-cell lymphoma.

Esmailzadeh S1, Huang Y2, Su MW3, Zhou Y3, Jiang X1.
Leukemia.Leukemia.2015 Jun;29(6):1402-13. doi: 10.1038/leu.2015.9. Epub 2015 Jan 12.
The bridging integrator 1 (BIN1) tumor suppressor encodes multiple alternatively spliced isoforms implicated in DNA repair, cell-cycle control, apoptosis and membrane dynamics. BIN1 attenuation has been reported in several solid tumors; however, the role of BIN1 in lymphomagenesis remains unexplored
PMID 25578476

Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11.

Dao P1, Smith N1, Scott-Algara D2, Garbay C1, Herbeuval JP1, Chen H3.
Cancer letters.Cancer Lett.2015 Apr 28;360(1):48-59. doi: 10.1016/j.canlet.2015.02.016. Epub 2015 Feb 12.
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a
PMID 25684663

Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10.

Allen JE1, Prabhu VV1, Talekar M1, van den Heuvel AP1, Lim B1, Dicker DT1, Fritz JL1, Beck A2, El-Deiry WS3.
Cancer research.Cancer Res.2015 Apr 15;75(8):1668-74. doi: 10.1158/0008-5472.CAN-14-2356. Epub 2015 Feb 13.
ONC201/TIC10 is a small-molecule inducer of the TRAIL gene under current investigation as a novel anticancer agent. In this study, we identify critical molecular determinants of ONC201 sensitivity offering potential utility as pharmacodynamic or predictive response markers. By screening a library of
PMID 25681273