同: FKBP

WordNet

executed with proper legal authority; "a binding contract"
the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
strip sewn over or along an edge for reinforcement or decoration
the capacity to attract and hold something
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 6th letter of the Roman alphabet (同)f

PrepTutorEJDIC

義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
蛋白(たんばく)質

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. シクロスポリンおよびタクロリムスの薬理学pharmacology of cyclosporine and tacrolimus [show details]
…family of cytoplasmic proteins present in most cells: cyclophilins for cyclosporine and FK-binding proteins for tacrolimus. The drug-receptor complex specifically and competitively binds to and inhibits calcineurin …
2. 成人における肝移植：免疫抑制の概要liver transplantation in adults overview of immunosuppression [show details]
…(FDA) for renal transplantation in 1999 . It is structurally similar to tacrolimus and binds the same target (FK-binding protein) but does not inhibit calcineurin. Instead, it blocks the transduction signal …
3. 移植片対宿主病の予防prevention of graft versus host disease [show details]
…Mechanism of action – Both CsA and Tac bind cyclophilin-related proteins (ie, cyclophilin and FK binding proteins [FKBP], respectively). The CNI-cyclophilin complex binds and inhibits calcineurin, which blocks …
4. 成人における心臓移植：免疫抑制療法の導入期と維持期heart transplantation in adults induction and maintenance of immunosuppressive therapy [show details]
…profile. Tacrolimus (Prograf), previously known as FK-506, is a macrolide compound derived from the fungus Streptomyces tsukubaensis. It binds to a cytoplasmic protein called FK binding protein and inhibits …
5. 肺移植後の免疫抑制の維持maintenance immunosuppression following lung transplantation [show details]
…immunosuppression by more than 90 percent of lung transplant recipients . TAC binds with the cytoplasmic immunophilin, FK binding protein 12 (FKBP-12), and inactivates calcineurin, thus inhibiting both IL-2 and …

English Journal

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

Spiekerkoetter E1, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M.
The Journal of clinical investigation.J Clin Invest.2013 Aug 1;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high-throughput luciferase reporter assay to screen 3,756 FDA-approved drugs and bioactive compounds for induction of BMPR2 sign
PMID 23867624

Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization.

Hopper JT1, Rawlings A, Afonso JP, Channing D, Layfield R, Oldham NJ.
Journal of the American Society for Mass Spectrometry.J Am Soc Mass Spectrom.2012 Oct;23(10):1757-67. Epub 2012 Jul 14.
It is now well established that electrospray ionization (ESI) is capable of introducing noncovalent protein assemblies into a desolvated environment, thereby allowing their analysis by mass spectrometry. The degree to which native interactions from the solution phase are preserved in this environmen
PMID 22797884

Avidity binding of human adenovirus serotypes 3 and 7 to the membrane cofactor CD46 triggers infection.

Trinh HV1, Lesage G, Chennamparampil V, Vollenweider B, Burckhardt CJ, Schauer S, Havenga M, Greber UF, Hemmi S.
Journal of virology.J Virol.2012 Feb;86(3):1623-37. doi: 10.1128/JVI.06181-11. Epub 2011 Nov 30.
The species B human adenoviruses (HAdVs) infect cells upon attaching to CD46 or desmoglein 2 (DSG-2) by one or several of their 12 fiber knob trimers (FKs). To test whether DSG-2 and CD46 simultaneously serve as virus receptors for adenovirus type 3 (Ad3), we performed individual and combined CD46/D
PMID 22130529

Related Links

FK506-Binding Proteins and Their Diverse Functions - PubMed

FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/trans peptidyl prolyl isomerase (PPIase) that catalyzes interconversion between prolyl cis/trans conformations.

Characterization of high molecular weight FK-506 binding ...

The immunoregulant FK-506 potently inhibits particular calcium-associated signal transduction events that occur early during T-lymphocyte activation and during IgE receptor-mediated exocytosis in mast cells. FK-506 binds to a growing family of receptors termed FK-506-binding proteins (FKBPs), the most abundant being a 12-kDa cytosolic receptor, FKBP12. To date, there is no formal evidence ...

Comparative analysis of FKBP family protein: evaluation ...

Background FK506-binding proteins (FKBPs) have become the subject of considerable interest in several fields, leading to the identification of several cellular and molecular pathways in which FKBPs impact prenatal development and pathogenesis of many human diseases. Main body This analysis revealed differences between how mammalian and Drosophila FKBPs mechanisms function in relation to the ...