細胞外シグナル制御キナーゼカスケード
WordNet
- arrange (open windows) on a computer desktop so that they overlap each other, with the title bars visible
- a small waterfall or series of small waterfalls
- a succession of stages or operations or processes or units; "progressing in severity as though a cascade of genetic damage was occurring"; "separation of isotopes by a cascade of processes"
- rush down in big quantities, like a cascade (同)cascade down
- the 5th letter of the Roman alphabet (同)e
PrepTutorEJDIC
- (いく筋にもなって落ちる)小滝,(庭園などの)人工滝 / 滝状になった物 / 小滝となって(小滝のように)落ちる
UpToDate Contents
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English Journal
- Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation.
- Wiebe JP1, Pawlak KJ2, Kwok A3.
- The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Jan;155(Pt A):166-76. doi: 10.1016/j.jsbmb.2015.10.021. Epub 2015 Oct 28.
- Previous studies have shown that breast tissues and breast cell lines can convert progesterone to 5α-pregnane-3,20-dione (5aP), and that 5αP stimulates breast cell proliferation and detachment in vitro, and tumor formation in vivo, regardless of presence or absence of receptors for progesterone (P
- PMID 26519986
- Mouse hippocampal phosphorylation footprint induced by generalized seizures: Focus on ERK, mTORC1 and Akt/GSK-3 pathways.
- Gangarossa G1, Sakkaki S2, Lory P3, Valjent E4.
- Neuroscience.Neuroscience.2015 Dec 17;311:474-83. doi: 10.1016/j.neuroscience.2015.10.051. Epub 2015 Nov 3.
- Exacerbated hippocampal activity has been associated to critical modifications of the intracellular signaling pathways. We have investigated rapid hippocampal adaptive responses induced by maximal electroshock seizure (MES). Here, we demonstrate that abnormal and exacerbated hippocampal activity ind
- PMID 26545981
- MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma.
- Fernandes JD1, Hsieh R, de Freitas LA, Brandao MA, Lourenço SV, Sangueza M, Nico MM.
- The American Journal of dermatopathology.Am J Dermatopathol.2015 Dec;37(12):892-7. doi: 10.1097/DAD.0000000000000317.
- The etiology and pathogenesis of lentiginous acral melanomas are poorly understood. Recent studies have postulated that DNA repair mechanisms and cell growth pathways are involved in the development of melanoma, particularly changes in the MAPK pathways (RAS, BRAF, MEK 1/2, and ERK 1/2). The aim of
- PMID 26588333
Japanese Journal
- DA-9801 Promotes Neurite Outgrowth <i>via</i> ERK1/2-CREB Pathway in PC12 Cells
- In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines.
- DA-9801 Promotes Neurite Outgrowth <i>via</i> ERK1/2-CREB Pathway in PC12 Cells
Related Links
- The MAPK/ERK pathway is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell. The signal starts when a signaling molecule binds to the receptor on the cell ...
- 以下、RasはMAPキナーゼカスケードへとシグナルを伝えていくが、RasはMAP キナーゼキナーゼキナーゼ (MAPKKK) であるRafを、RafはMAPキナーゼキナーゼで あるMAPK/ERK kinase (MEK) を活性化し、このMEKによりERKの活性化が 引き起こされる。
★リンクテーブル★
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- 英
- extracellular signal-regulated kinase cascade, ERK cascade
- 関
- ERKカスケード
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- 同
- [[]] extracellular-signal-regulated kinase
- 関
- MAPキナーゼスーパーファミリーカスケード
- MAPKファミリーに含まれるERKファミリーを構成
- キナーゼサブドメインVIIIの活性化ループに存在するリン酸化部位の配列がTEY
- セリンスレオニンキナーゼ
- MAPKKであるMEK1,MEK2によってスレオニンとチロシン残基がリン酸化され、活性化される。
- ERK1/2の基質
- 同
- extracellular-signal-regulated kinase
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