DNAポリメラーゼδ
- 関
- DNAポリメラーゼIII、DNA polymerase III、Pol III
WordNet
- an object shaped like an equilateral triangle
- a low triangular area of alluvial deposits where a river divides before entering a larger body of water; "the Mississippi River delta"; "the Nile delta"
- the 4th letter of the Greek alphabet
- the 4th letter of the Roman alphabet (同)d
- an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA
PrepTutorEJDIC
- デルタ(ギリシア語アルファベットの第4字Δ,δ;英語D,dに相当) / (河口の)三角州,デルタ / 三角形をしたもの
- deuteriumの化学記号
- deoxyribonucleic acidディオキシリボ核酸
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/04 18:53:56」(JST)
[Wiki en表示]
| DNA-directed DNA polymerase |
| Identifiers |
| EC number |
2.7.7.7 |
| CAS number |
9012-90-2 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
DNA polymerase delta is an enzyme complex found in eukaryotes that is involved in DNA replication and repair. The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4.[1] DNA Pol δ is the enzyme used primarily for lagging strand synthesis. It exhibits increased processivity when interacting with the proliferating cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor C, through its role as the as clamp loader for PCNA (whichinvolves catalysing the loading of PCNA on to DNA) is important for DNA Pol δ function.
References
- ^ Liu G, Warbrick E (October 2006). "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins". Biochem. Biophys. Res. Commun. 349 (1): 360–6. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752.
External links
- DNA polymerase delta at the US National Library of Medicine Medical Subject Headings (MeSH)
|
DNA replication (comparing Prokaryotic to Eukaryotic)
|
|
| Initiation |
Prokaryotic
(initiation) |
|
|
Eukaryotic
(preparation in
G1 phase) |
- Origin recognition complex
- ORC1
- ORC2
- ORC3
- ORC4
- ORC5
- ORC6
- Minichromosome maintenance
- MCM2
- MCM3
- MCM4
- MCM5
- MCM6
- MCM7
- Autonomously replicating sequence
- Single-strand binding protein
|
|
| Both |
- Origin of replication/Ori/Replicon
- Replication fork
- Lagging and leading strands
- Okazaki fragment
- Primer
|
|
|
| Replication |
Prokaryotic
(elongation) |
- DNA polymerase III holoenzyme
- dnaC
- dnaE
- dnaH
- dnaN
- dnaQ
- dnaT
- dnaX
- holA
- holB
- holC
- holD
- holE
- Replisome
- DNA ligase
- DNA clamp
- Topoisomerase
- Prokaryotic DNA polymerase: DNA polymerase I
|
|
Eukaryotic
(synthesis in
S phase) |
- Replication factor C
- Flap endonuclease
- Topoisomerase
- Replication protein A
- Eukaryotic DNA polymerase:
- alpha
- delta
- epsilon
|
|
| Both |
- Movement: Processivity
- DNA ligase
|
|
|
| Termination |
|
|
See also: DNA replication and repair-deficiency disorder
- ''B bsyn: dna
- tscr
- fact
- tcrg
- nucl
- rnat
- rept
- ptts
- tltn
- pttl
- dnab
- stru
|
|
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
UpToDate Contents
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English Journal
- The current status and future directions of hepatitis B antiviral drug discovery.
- Tang L1, Zhao Q2, Wu S2, Cheng J2, Chang J2, Guo JT2.
- Expert opinion on drug discovery.Expert Opin Drug Discov.2017 Jan;12(1):5-15. Epub 2016 Nov 11.
- INTRODUCTION: The current standard care of chronic hepatitis B fails to induce a durable off-drug control of hepatitis B virus (HBV) replication in the majority of treated patients. The primary reasons are its inability to eliminate the covalently closed circular (ccc) DNA, the nuclear form of HBV g
- PMID 27797587
- A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity.
- Lin S1, Kang TS2, Lu L3, Wang W1, Ma DL4, Leung CH5.
- Biosensors & bioelectronics.Biosens Bioelectron.2016 Dec 15;86:849-57. doi: 10.1016/j.bios.2016.07.082. Epub 2016 Jul 25.
- Thymine DNA glycosylase (TDG) performs essential functions in maintaining genetic integrity and epigenetic regulation, which also plays an essential role in DNA demethylation. In this work, the novel iridium(III) complex 1 with an anchor tail was synthesized and employed to construct a G-quadruplex-
- PMID 27494808
- Simultaneous Identification of Four "Legal High" Plant Species in a Multiplex PCR High-Resolution Melt Assay.
- Elkins KM1, Perez AC1, Quinn AA1.
- Journal of forensic sciences.J Forensic Sci.2016 Dec 13. doi: 10.1111/1556-4029.13321. [Epub ahead of print]
- The international prevalence of "legal high" drugs necessitates the development of a method for their detection and identification. Herein, we describe the development and validation of a tetraplex multiplex real-time polymerase chain reaction (PCR) assay used to simultaneously identify morning glor
- PMID 27957736
Japanese Journal
- Molecular phylogenetic analyses support the monophyly of Hexapoda and suggest the paraphyly of Entognatha
- P-064 DNA polymerase κ遺伝子ノックインgpt deltaマウスにおいてmitomycin Cによって骨髄に誘発された変異の解析(ポスターセッション)
- P-063 DNAポリメラーゼκノックインマウスにおける自然突然変異の解析(ポスターセッション)
Related Links
- GeneTex社の 抗DNA polymerase deltaポリクローナル抗体(Anti-DNA polymerase delta) | DNA polymerase delta antibody (ウサギポリクローナル抗体)です。※本製品は研究目的にのみ販売しております。医薬品，診断医薬品，食品，食品 ...
- Prokaryotic DNA polymerase [edit] Pol I [edit] Prokaryotic Family A polymerases include the DNA polymerase I (Pol I) enzyme, which is encoded by the polA gene and ubiquitous among prokaryotes. This repair polymerase is ...
★リンクテーブル★
[★]
- 関
- DNA polymerase delta、DNA polymerase III、RNA polymerase III
[★]
[★]
- 英
- deoxyribonucleic acid
- 同
- デオキシリボ核酸
- 関
- リボ核酸 RNA
[★]
δ、デルタ