WordNet
- the 4th letter of the Roman alphabet (同)d
- any of the enzymes that catalyze biological oxidation
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- deuteriumの化学記号
- (おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/08/06 15:31:38」(JST)
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D-aspartate oxidase |
Identifiers |
EC number |
1.4.3.1 |
CAS number |
9029-20-3 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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In enzymology, a D-aspartate oxidase (EC 1.4.3.1) is an enzyme that catalyzes the chemical reaction
- D-aspartate + H2O + O2 oxaloacetate + NH3 + H2O2
The 3 substrates of this enzyme are D-aspartate, H2O, and O2, whereas its 3 products are oxaloacetate, NH3, and H2O2.
This enzyme belongs to the FAD dependent oxidoreductase family, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is D-aspartate:oxygen oxidoreductase (deaminating). Other names in common use include aspartic oxidase, and D-aspartic oxidase. This enzyme participates in alanine and aspartate metabolism. It employs one cofactor, FAD.
The enzyme is encoded by DDO gene.
References[edit source | edit]
- Dixon M, Kenworthy P (1967). "D-aspartate oxidase of kidney". Biochim. Biophys. Acta. 146 (1): 54–76. PMID 6060479.
- Still JL, Buell MV, Knox WE and Green DE (1949). "Studies on the cyclophorase system. VII. D-Aspartic oxidase". J. Biol. Chem. 179: 831–837.
- Still JL and Sperling E (1950). "On the prosthetic group of the D-aspartic oxidase". J. Biol. Chem. 182: 585–589.
CH-NH2 oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
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1.4.1: NAD/NADP acceptor |
- Glutamate dehydrogenase
- Glutamate synthase (NADPH)
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1.4.3: oxygen acceptor |
- D-amino acid oxidase
- Amine oxidase
- Lysyl oxidase
- Monoamine oxidase
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1.4.4: disulfide acceptor |
- Glycine decarboxylase complex
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1.4.99: other acceptors |
- D-amino acid dehydrogenase
- Amine dehydrogenase
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Changes in d-aspartic acid and d-glutamic acid levels in the tissues and physiological fluids of mice with various d-aspartate oxidase activities.
- Han H1, Miyoshi Y2, Koga R2, Mita M3, Konno R4, Hamase K5.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2015 Dec 10;116:47-52. doi: 10.1016/j.jpba.2015.05.013. Epub 2015 May 22.
- d-Aspartic acid (d-Asp) and d-glutamic acid (d-Glu) are currently paid attention as modulators of neuronal transmission and hormonal secretion. These two d-amino acids are metabolized only by d-aspartate oxidase (DDO) in mammals. Therefore, in order to design and develop new drugs controlling the d-
- PMID 26058797
- d-Aspartate: An endogenous NMDA receptor agonist enriched in the developing brain with potential involvement in schizophrenia.
- Errico F1, Mothet JP2, Usiello A3.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2015 Dec 10;116:7-17. doi: 10.1016/j.jpba.2015.03.024. Epub 2015 Mar 31.
- Free d-aspartate and d-serine occur at substantial levels in the mammalian brain. d-Serine is a physiological endogenous co-agonist for synaptic N-Methyl d-Aspartate (NMDA) receptors (NMDARs), and is involved in the pathophysiology of schizophrenia. Much less is known about the biological meaning of
- PMID 25868730
- Experimental approaches for elucidating co-agonist regulation of NMDA receptor in motor neurons: Therapeutic implications for amyotrophic lateral sclerosis (ALS).
- Paul P1, de Belleroche J2.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2015 Dec 10;116:2-6. doi: 10.1016/j.jpba.2014.12.040. Epub 2015 Jan 3.
- Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease characterised by selective loss of motor neurons leading to fatal paralysis. Although most cases are sporadic, approximately 10% of cases are familial and the identification of mutations in these kindred has greatly accelerated our under
- PMID 25604957
Japanese Journal
- Enzymatic Assay for D-Aspartic Acid Using D-Aspartate Oxidase and Oxaloacetate Decarboxylase
- KATO Shiro,IKUTA Tomoyuki,HEMMI Hisashi [他],TAKAHASHI Shoji,KERA Yoshio,YOSHIMURA Tohru
- Bioscience, biotechnology, and biochemistry 76(11), 2150-2152, 2012-11-23
- NAID 10031126525
- 3Cp03 酵母Cryptococcus humicola由来D-アスパラギン酸オキシダーゼの結晶構造解析(酵素学,酵素工学,一般講演)
- 高橋 祥司,後藤 勝,小森 広大,大河内 里美,阿部 勝正,解良 芳夫
- 日本生物工学会大会講演要旨集 64, 123, 2012-09-25
- NAID 110009609669
- FADおよびFADH₂存在下におけるD-アスパラギン酸酸化酵素とD-アスパラギン酸のドッキングシミュレーション
Related Links
- GoPubMed lists recent and important papers and reviews for DDO D-aspartate oxidase(D-aspartate oxidase) ... Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility. Usiello et al., Napoli, Italy.
- 1.1.|The d-aspartate oxidase (d-aspartate:oxygen oxidoreductase (deaminating), EC 1.4.3.1.) of rabbit kidney has been purified almost 100-fold. Although it is n ... Abstract 1. 1.|The d-aspartate oxidase (d-aspartate:oxygen ...
★リンクテーブル★
[★]
- 英
- D-aspartate oxidase
- 関
- D-アスパラギン酸オキシダーゼ
[★]
- 英
- D-aspartate oxidase
- 関
- D-アスパラギン酸酸化酵素
[★]
[★]
アスパラギン酸、アスパラギン酸塩
- 関
- Asp、aspartic、aspartic acid、D、L-aspartate、L-aspartic acid、magnesium aspartate、potassium aspartate
- aspartic acid