WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
- the 4th letter of the Roman alphabet (同)d
- pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
- the radical -NH2 (同)amino_group
- any of the enzymes that catalyze biological oxidation
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
- deuteriumの化学記号
- (おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/29 01:10:37」(JST)
[Wiki en表示]
| D-amino-acid oxidase |
3D structure of DAAO from yeast (monomer)
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| Identifiers |
| EC number |
1.4.3.3 |
| CAS number |
9000-88-8 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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| D-amino-acid oxidase |
| Identifiers |
| Symbol |
DAO (DAAO) |
| Entrez |
1610 |
| HUGO |
2671 |
| OMIM |
124050 |
| RefSeq |
NM_001917 |
| UniProt |
P14920 |
| Other data |
| EC number |
1.4.3.3 |
| Locus |
Chr. 12 q24 |
D-amino acid oxidase (DAAO; also DAO, OXDA, DAMOX) is a peroxisomal enzyme containing FAD as cofactor that is expressed in a wide range of species from yeasts to human.[1] It is not present in plants or in bacteria which instead use D-amino acid dehydrogenase. Its function is to oxidize D-amino acids to the corresponding imino acids, producing ammonia and hydrogen peroxide.
This enzyme belongs to the FAD dependent oxidoreductase family, and acts on the CH-NH2 group of D-amino acid donors with oxygen as acceptor. The enzyme is most active toward neutral D-amino acids, and not active toward acidic D-amino acids.
Recently, mammalian D-amino acid oxidase has been connected to the brain D-serine metabolism and to the regulation of the glutamatergic neurotransmission. In a postmortem study, the activity of DAAO was found to be two-fold higher in schizophrenia.[2]
DAAO is a candidate susceptibility gene[3] and together with G72 may play a role in the glutamatergic mechanisms of schizophrenia.[4]
DAAO is used as a biocatalyst in several biotechnological applications, such as the oxidation of cephalosporin C, the deracemition of racemic D-amino acid solutions and as the biological component in several biosensors for the determination of the content in D-amino acids of biological fluids.
This protein may use the morpheein model of allosteric regulation. [5]
See also[edit source | edit]
- D-amino acid oxidase activator
- D-amino acid dehydrogenase
- D-aspartate oxidase
External links[edit source | edit]
- D-Amino-Acid Oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
- http://www.calzyme.com/commerce/catalog/spcategory.jsp?category_id=1043
References[edit source | edit]
- ^ Pollegioni L, Piubelli L, Sacchi S, Pilone MS, Molla G (June 2007). "Physiological functions of D-amino acid oxidases: from yeast to humans". Cell. Mol. Life Sci. 64 (11): 1373–94. doi:10.1007/s00018-007-6558-4. PMID 17396222.
- ^ Madeira C, Freitas ME, Vargas-Lopes C, Wolosker H, Panizzutti R (April 2008). "Increased brain d-amino acid oxidase (DAAO) activity in schizophrenia". Schizophr. Res. 101 (1–3): 76–83. doi:10.1016/j.schres.2008.02.002. PMID 18378121.
- ^ Gene Overview of All Published Schizophrenia-Association Studies for DAAO - SZGene database.
- ^ Boks MP, Rietkerk T, van de Beek MH, Sommer IE, de Koning TJ, Kahn RS (September 2007). "Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia". Eur Neuropsychopharmacol 17 (9): 567–72. doi:10.1016/j.euroneuro.2006.12.003. PMID 17250995.
- ^ T. Selwood and E. K. Jaffe. (2011). "Dynamic dissociating homo-oligomers and the control of protein function.". Arch. Biochem. Biophys. 519 (2): 131–43. doi:10.1016/j.abb.2011.11.020. PMC 3298769. PMID 22182754.
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CH-NH2 oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
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| 1.4.1: NAD/NADP acceptor |
- Glutamate dehydrogenase
- Glutamate synthase (NADPH)
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| 1.4.3: oxygen acceptor |
- D-amino acid oxidase
- Amine oxidase
- Lysyl oxidase
- Monoamine oxidase
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| 1.4.4: disulfide acceptor |
- Glycine decarboxylase complex
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| 1.4.99: other acceptors |
- D-amino acid dehydrogenase
- Amine dehydrogenase
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Glycinergics
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Receptor
ligands |
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Agonists
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- Alanine
- Cycloserine
- Dimethylglycine
- Glycine
- Hypotaurine
- Methylglycine (Sarcosine)
- Milacemide
- Quisqualamine
- Serine
- Taurine
- Trimethylglycine (Betaine)
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Antagonists
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- Bicuculline
- Brucine
- Caffeine
- Picrotoxin
- Pitrazepin
- Strychnine
- Thiocolchicoside
- Tutin
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Reuptake
inhibitors |
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Plasmalemmal
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GlyT1 inhibitors
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Ethanol
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GlyT2 inhibitors
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Ethanol
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Vesicular
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Enzyme
inhibitors |
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Anabolism/Catabolism
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SHMT Inhibitors
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GDC Inhibitors
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DAAO Inhibitors
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| Others |
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Precursors
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- 3-Phosphoglyceric acid
- Serine
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Cofactors
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- Vitamin B6 (Pyridoxine
- pyridoxamine
- pyridoxal → pyridoxal phosphate)
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English Journal
- Graphene oxide nanoribbon-based sensors for the simultaneous bio-electrochemical enantiomeric resolution and analysis of amino acid biomarkers.
- Martín A1, Batalla P1, Hernández-Ferrer J2, Martínez MT2, Escarpa A3.
- Biosensors & bioelectronics.Biosens Bioelectron.2015 Jun 15;68:163-7. doi: 10.1016/j.bios.2014.12.030. Epub 2014 Dec 12.
- In this work, a straightforward in-situ measurement of L and D-amino acids (AAs) has been developed using disposable graphene oxide nanoribbon (GON) screen printed electrodes. For that, we took advantage of the electroactivity of certain clinically relevant AAs, such as tyrosine (Tyr) and methionine
- PMID 25562744
- Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity.
- Nickl-Jockschat T1, Stöcker T, Krug A, Markov V, Maximov II, Huang R, Schneider F, Habel U, Eickhoff SB, Zerres K, Nöthen MM, Rietschel M, Jon Shah N, Treutlein J, Kircher T.
- European archives of psychiatry and clinical neuroscience.Eur Arch Psychiatry Clin Neurosci.2015 Jun;265(4):291-301. doi: 10.1007/s00406-014-0516-6. Epub 2014 Jul 17.
- G72 (syn. DAOA, D-amino acid oxidase activator) is a susceptibility gene for both schizophrenia and bipolar disorder. Diffusion tensor imaging studies hint at changes in fiber tract integrity in both disorders. We aimed to investigate whether a G72 susceptibility haplotype causes changes in fiber tr
- PMID 25031104
- Enzyme-Based Microfluidic Chip Coupled to Graphene Electrodes for the Detection of D-Amino Acid Enantiomer-Biomarkers.
- Batalla P1, Martín A1, López MÁ1, González MC1, Escarpa A1.
- Analytical chemistry.Anal Chem.2015 May 2. [Epub ahead of print]
- An electrochemical microfluidic strategy for the separation and enantiomeric detection of d-methionine (d-Met) and d-leucine (d-Leu) is presented. These D-amino acids (D-AAs) act as biomarkers involved in relevant diseases caused by Vibrio cholerae. On a single layout microfluidic chip (MC), highly
- PMID 25870911
Japanese Journal
- Identification of two promoters for human D-amino acid oxidase gene : implication for the differential promoter regulation mediated by PAX5/PAX2
- Tran Diem Hong,Shishido Yuji,Chung Seong Pil [他]
- The journal of biochemistry 157(5), 377-387, 2015-05
- NAID 40020461475
- Characterization of the Enzymatic and Structural Properties of Human D-Aspartate Oxidase and Comparison with Those of the Rat and Mouse Enzymes
- Katane Masumi,Kawata Tomonori,Nakayama Kazuki [他],Saitoh Yuki,Kaneko Yuusuke,Matsuda Satsuki,Saitoh Yasuaki,Miyamoto Tetsuya,Sekine Masae,Homma Hiroshi
- Biological and Pharmaceutical Bulletin 38(2), 298-305, 2015
- … D-Aspartate (D-Asp), a free D-amino acid found in mammals, plays crucial roles in the neuroendocrine, endocrine, and central nervous systems. … Recent studies have implicated D-Asp in the pathophysiology of infertility and N-methyl-D-Asp receptor-related diseases. …
- NAID 130004872265
- ビタミンB群が担う脳内D-アミノ酸代謝システムの疾患酵素学研究(<特集>ビタミンB研究委員会平成25年度シンポジウム「ビタミンB群が担う脳内アミノ酸代謝と疾患をターゲットにした次世代学術研究-ビタミン研究が切り拓く疾患生命科学のフロンティア」)
- 福井 清
- ビタミン 88(10), 524-529, 2014-10-25
- … D-Amino acid oxidase (DAO) is a flavoenzyme that catalyses the oxidative deamination of D-amino acids. … D-Serine, one of the physiological substrates for DAO, is an endogenous co-agonist for N-methyl D-aspartate (NMDA) receptor and plays important roles in glutamate receptor-mediated neurotransmission. …
- NAID 110009891164
Related Links
- The schizophrenia-related protein G72 plays a unique role in the regulation of D-amino acid oxidase (DAO) in great apes. Several psychiatric diseases, including schizophrenia and bipolar disorder, are linked to overexpression of DAO ...
- D-amino Acid Oxidase , Find Complete Details about D-amino Acid Oxidase,D-amino Acid Oxidase from Supplier or Manufacturer-CHYG CHEMICALS Welcome Buy How to buy Post Buying Requests Download TradeManager ...
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