- 同
- Interleukin-5 receptor, α-chain
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/24 15:56:45」(JST)
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| Interleukin 5 receptor, alpha |
Rendering of IL5RA from PDB 1OBX |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1OBX, 1OBZ, 3QT2, 3VA2
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| Identifiers |
| Symbols |
IL5RA; CD125; CDw125; HSIL5R3; IL5R |
| External IDs |
OMIM: 147851 MGI: 96558 HomoloGene: 473 GeneCards: IL5RA Gene |
| Gene Ontology |
| Molecular function |
• interleukin-5 receptor activity
• protein binding
|
| Cellular component |
• extracellular space
• plasma membrane
• integral to membrane
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| Biological process |
• inflammatory response to antigenic stimulus
• signal transduction
• cell proliferation
• regulation of interleukin-5 production
• interleukin-5-mediated signaling pathway
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
3568 |
16192 |
|
| Ensembl |
ENSG00000091181 |
ENSMUSG00000005364 |
|
| UniProt |
Q01344 |
P21183 |
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| RefSeq (mRNA) |
NM_000564 |
NM_008370 |
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| RefSeq (protein) |
NP_000555 |
NP_032396 |
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| Location (UCSC) |
Chr 3:
3.11 – 3.17 Mb |
Chr 6:
106.71 – 106.75 Mb |
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| PubMed search |
[1] |
[2] |
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Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.[1]
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.[1]
Contents
- 1 Interactions
- 2 See also
- 3 References
- 4 Further reading
- 5 External links
Interactions[edit]
Interleukin 5 receptor alpha subunit has been shown to interact with Protein unc-119 homolog,[2] Interleukin 5,[3][4][5] SDCBP[6] and Janus kinase 2.[7]
See also[edit]
- Cluster of differentiation
References[edit]
- ^ a b "Entrez Gene: IL5RA interleukin 5 receptor, alpha".
- ^ Cen, Osman; Gorska Magdalena M, Stafford Susan J, Sur Sanjiv, Alam Rafeul (Mar. 2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases". J. Biol. Chem. (United States) 278 (10): 8837–45. doi:10.1074/jbc.M208261200. ISSN 0021-9258. PMID 12496276.
- ^ Woodcock, J M; Zacharakis B, Plaetinck G, Bagley C J, Qiyu S, Hercus T R, Tavernier J, Lopez A F (Nov. 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. (ENGLAND) 13 (21): 5176–85. ISSN 0261-4189. PMC 395466. PMID 7957082.
- ^ Johanson, K; Appelbaum E, Doyle M, Hensley P, Zhao B, Abdel-Meguid S S, Young P, Cook R, Carr S, Matico R (Apr. 1995). "Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins". J. Biol. Chem. (UNITED STATES) 270 (16): 9459–71. doi:10.1074/jbc.270.16.9459. ISSN 0021-9258. PMID 7721873.
- ^ Murata, Y; Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K (Feb. 1992). "Molecular cloning and expression of the human interleukin 5 receptor". J. Exp. Med. (UNITED STATES) 175 (2): 341–51. doi:10.1084/jem.175.2.341. ISSN 0022-1007. PMC 2119102. PMID 1732409.
- ^ Geijsen, N; Uings I J, Pals C, Armstrong J, McKinnon M, Raaijmakers J A, Lammers J W, Koenderman L, Coffer P J (Aug. 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science (United States) 293 (5532): 1136–8. doi:10.1126/science.1059157. ISSN 0036-8075. PMID 11498591.
- ^ Ogata, N; Kouro T, Yamada A, Koike M, Hanai N, Ishikawa T, Takatsu K (Apr. 1998). "JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation". Blood (UNITED STATES) 91 (7): 2264–71. ISSN 0006-4971. PMID 9516124.
Further reading[edit]
- Isobe M, Kumura Y, Murata Y, et al. (1992). "Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26.". Genomics 14 (3): 755–8. doi:10.1016/S0888-7543(05)80180-6. PMID 1427903.
- Tuypens T, Plaetinck G, Baker E, et al. (1993). "Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene.". Eur. Cytokine Netw. 3 (5): 451–9. PMID 1477296.
- Tavernier J, Tuypens T, Plaetinck G, et al. (1992). "Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.". Proc. Natl. Acad. Sci. U.S.A. 89 (15): 7041–5. doi:10.1073/pnas.89.15.7041. PMC 49641. PMID 1495999.
- Scott HS, Guo XH, Hopwood JJ, Morris CP (1992). "Structure and sequence of the human alpha-L-iduronidase gene.". Genomics 13 (4): 1311–3. doi:10.1016/0888-7543(92)90053-U. PMID 1505961.
- Murata Y, Takaki S, Migita M, et al. (1992). "Molecular cloning and expression of the human interleukin 5 receptor.". J. Exp. Med. 175 (2): 341–51. doi:10.1084/jem.175.2.341. PMC 2119102. PMID 1732409.
- Tavernier J, Devos R, Cornelis S, et al. (1991). "A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF.". Cell 66 (6): 1175–84. doi:10.1016/0092-8674(91)90040-6. PMID 1833065.
- Johanson K, Appelbaum E, Doyle M, et al. (1995). "Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins.". J. Biol. Chem. 270 (16): 9459–71. doi:10.1074/jbc.270.16.9459. PMID 7721873.
- Sun Z, Yergeau DA, Tuypens T, et al. (1995). "Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene.". J. Biol. Chem. 270 (3): 1462–71. doi:10.1074/jbc.270.3.1462. PMID 7836416.
- Hori K, Hirashima M, Ueno M, et al. (1993). "Regulation of eosinophil migration by adult T cell leukemia-derived factor.". J. Immunol. 151 (10): 5624–30. PMID 8228251.
- Huston MM, Moore JP, Mettes HJ, et al. (1996). "Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis.". J. Immunol. 156 (4): 1392–401. PMID 8568239.
- Monahan J, Siegel N, Keith R, et al. (1997). "Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor.". J. Immunol. 159 (8): 4024–34. PMID 9378992.
- Ogata N, Kouro T, Yamada A, et al. (1998). "JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.". Blood 91 (7): 2264–71. PMID 9516124.
- Tavernier J, Van der Heyden J, Verhee A, et al. (2000). "Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit.". Blood 95 (5): 1600–7. PMID 10688814.
- Czabotar PE, Holland J, Sanderson CJ (2000). "Identification of regions within the third FnIII-like domain of the IL-5Ralpha involved in IL-5 interaction.". Cytokine 12 (7): 867–73. doi:10.1006/cyto.1999.0663. PMID 10880230.
- Plugariu CG, Wu SJ, Zhang W, Chaiken I (2001). "Multisite mutagenesis of interleukin 5 differentiates sites for receptor recognition and receptor activation.". Biochemistry 39 (48): 14939–49. doi:10.1021/bi001467p. PMID 11101310.
- Geijsen N, Uings IJ, Pals C, et al. (2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.". Science 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591.
- Upham JW, Sehmi R, Hayes LM, et al. (2002). "Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells.". J. Allergy Clin. Immunol. 109 (2): 307–13. doi:10.1067/mai.2002.121527. PMID 11842302.
- Rizzo CA, Yang R, Greenfeder S, et al. (2002). "The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness.". J. Allergy Clin. Immunol. 109 (3): 404–9. doi:10.1067/mai.2002.122459. PMID 11897983.
- Scibek JJ, Evergren E, Zahn S, et al. (2003). "Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes.". Anal. Biochem. 307 (2): 258–65. doi:10.1016/S0003-2697(02)00043-X. PMID 12202242.
- Liu LY, Sedgwick JB, Bates ME, et al. (2002). "Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge.". J. Immunol. 169 (11): 6452–8. PMID 12444154.
External links[edit]
- IL5RA protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Cytokine receptors
|
|
Chemokine receptor
(GPCRs) |
| CC |
- CCR1/CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
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|
| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
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| Other |
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|
| TNF receptor |
| 1-10 |
- TNFRSF1 (CD120)
- TNFRSF1A (CD120a)
- TNFRSF1B (CD120b)
- TNFRSF3 (Lymphotoxin beta receptor)
- TNFRSF4 (CD134)
- TNFRSF5 (CD40)
- TNFRSF6 (FAS)
- TNFRSF6B
- TNFRSF7 (CD27)
- TNFRSF8 (CD30)
- TNFRSF9 (CD137)
|
|
| 11-20 |
- TNFRSF10A (CD261)
- TNFRSF10B (CD262)
- TNFRSF10C (CD263)
- TNFRSF10D (CD264)
- TNFRSF11A (CD265/RANK)
- TNFRSF11B (Osteoprotegerin)
- TNFRSF12A (CD266)
- TNFRSF13B (CD267)
- TNFRSF13C
- TNFRSF14 (CD268)
- TNFRSF16 (Nerve growth factor receptor)
- TNFRSF17 (CD269)
- TNFRSF18
- TNFRSF19
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| 21-25 |
- TNFRSF21
- TNFRSF25
- TNFRSF27
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| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R/IL2RA/IL2RB/IL15R
- IL4R/IL13R/IL13RA1/IL13RA2
- IL7R/IL7RA
- IL9R
- IL21R
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| β-chain |
- Interleukin receptors
- GM-CSF
|
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| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
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| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
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| Other |
- hormone receptor: GH
- prolactin
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| Type II |
- Interleukin receptors
- IL10R/IL10RA/IL10RB/IL22R/IL22RA2
- IL20R/IL20RA/IL20RB
- IL28R
- Interferon receptors
- -α/β/IFNAR1/IFNAR2
- -γ/IFNGR1/IFNGR2
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| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R/IL18R1
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| IL 17 family |
- IL-17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
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| S/T |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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English Journal
- Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The İstanbul Perspective.
- Karakaş Z, Koç B1, Temurhan S, Elgün T, Karaman S, Asker G, Gençay G, Timur Ç, Yıldırmak ZY, Celkan T, Devecioğlu Ö, Aydın F.
- Turkish journal of haematology : official journal of Turkish Society of Haematology.Turk J Haematol.2015 Dec 5;32(4):344-350. doi: 10.4274/tjh.2014.0204. Epub 2015 Aug 6.
- in
English, TurkishAmaç: Alfa talasemi sendromları, bir ya da daha fazla a-globin genindeki mutasyonlardan kaynaklanır. Mutasyonlar genelikle delesyonel olmakla birlikte non-delesyonel de olabilir. Bazı delesyonlar (3.7 ve 4.2) α+-talasemiye neden olurken bazıları da (-20.5, MED, THAI, FI
- Expansion of CD25+ Innate Lymphoid Cells Reduces Atherosclerosis.
- Engelbertsen D1, Foks AC1, Alberts-Grill N1, Kuperwaser F1, Chen T1, Lederer JA1, Jarolim P1, Grabie N1, Lichtman AH2.
- Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2015 Dec;35(12):2526-35. doi: 10.1161/ATVBAHA.115.306048. Epub 2015 Oct 22.
- OBJECTIVE: Innate lymphoid cells (ILCs) are a newly discovered subset of immune cells that promote tissue homeostasis and protect against pathogens. ILCs produce cytokines also produced by T lymphocytes that have been shown to affect atherosclerosis, but the influence of ILCs on atherosclerosis has
- PMID 26494229
- IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils.
- Esnault S1, Kelly EA2, Shen ZJ3, Johansson MW4, Malter JS3, Jarjour NN2.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Sep 15;195(6):2529-39. doi: 10.4049/jimmunol.1500871. Epub 2015 Aug 14.
- IL-5 is a major therapeutic target to reduce eosinophilia. However, all of the eosinophil-activating cytokines, such as IL-5, IL-3, and GM-CSF, are typically present in atopic diseases, including allergic asthma. As a result of the functional redundancy of these three cytokines on eosinophils and th
- PMID 26276876
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[★]
- 英
- interleukin-5, interleukin 5
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種類
発現組織
- 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)
分子量
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