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Ag-bearing liposomes engrafted with peptides that interact with CD11c/CD18 induce potent Ag-specific and antitumor immunity.

Faham A, Altin JG.SourceDivision of Biomedical Science and Biochemistry, Research School of Biology, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia.
International journal of cancer. Journal international du cancer.Int J Cancer.2011 Sep 15;129(6):1391-403. doi: 10.1002/ijc.25810. Epub 2011 Mar 25.
Dendritic cells (DCs) play key role in eliciting antigen (Ag)-specific immune responses, and crucial to this is the uptake of Ag via surface receptors including the heterodimeric integrin CD11c/CD18. Here we report that CD11c/CD18-interacting peptides can be used as targeting moieties to deliver lip
PMID 21128234

Trauma-Activated Polymorphonucleated Leukocytes Damage Endothelial Progenitor Cells: Probable Role of CD11b/CD18-CD54 Interaction and Release of Reactive Oxygen Species.

Henrich D, Zimmer S, Seebach C, Frank J, Barker J, Marzi I.SourceDepartment of Trauma, Hand and Reconstructive Surgery, Johann-Wolfgang-Goethe University, Frankfurt, Germany.
Shock (Augusta, Ga.).Shock.2011 Sep;36(3):216-22.
Endothelial progenitor cells (EPCs) and polymorphonucleated leukocytes (PMNLs) migrate to and accumulate at the site of tissue injury where they express complementary sets of surface receptors (CD11b/CD18, CD54), suggesting a possible cellular interaction. Trauma-activated PMNLs release inflammatory
PMID 21610569

Canine neutrophil dysfunction caused by downregulation of β2-integrin expression without mutation

Kobayashi Saori,Sato Reeko,Abe Yuya,Inanami Osamu,Yasui Hironobu,Omoe Ktsuhiko,Yasuda Jun,Hankanga Careen,Oda Shinichi,Sasaki Juso
Veterinary Immunology and Immunopathology 130(3-4), 187-196, 2009
… Canine leukocyte adhesion deficiency (CLAD) in Irish setters is caused by genetic defects of leukocyte integrin CD18 leading to recurrent bacterial infections. … There was also a profound decrease of surface expression of CD11b/CD18 and β2-integrin transcript level, detected by real-time RT-PCR without missense mutations unlike CLAD. …
NAID 120001700548