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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/21 13:11:20」(JST)

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C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.^[1]

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.^[2]

Interactions

CCR1 has been shown to interact with CCL5.^[3]^[4]

References

^ Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (Mar 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328.
^ "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".
^ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (Jul 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. (Germany) 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. ISSN 0014-2980. PMID 11449371.
^ Proudfoot, A E; Fritchley S; Borlat F; Shaw J P; Vilbois F; Zwahlen C; Trkola A; Marchant D; Clapham P R; Wells T N (Apr 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". J. Biol. Chem. (United States) 276 (14): 10620–6. doi:10.1074/jbc.M010867200. ISSN 0021-9258. PMID 11116158.

External links

"Chemokine Receptors: CCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

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English Journal

Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: molecular basis for recruitment of the granulocyte infiltrate.

Fundová P, Funda DP, Kovář D, Holý R, Navara M, Tlaskalová-Hogenová H.SourceENT Department of the 3rd Faculty of Medicine, Charles University and the Central Military Hospital, U vojenské nemocnice 1200, 169 02, Prague 6, Czech Republic, pdfunda@seznam.cz.
Folia microbiologica.Folia Microbiol (Praha).2013 May;58(3):219-24. doi: 10.1007/s12223-012-0194-6. Epub 2012 Oct 11.
Inflammatory processes play an important role in the development of nasal polyps (NP), but the etiology and, to a high degree also, the pathogenesis of NP are not fully understood. The role of several cytokines and chemokines such as eotaxins, IL-4, IL-5, IL-6, IL-8, and RANTES has been reported in
PMID 23054685

RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke.

Tokami H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, Kiyohara Y, Kamouchi M, Kitazono T; for the REBIOS Investigators.SourceDepartment of Clinical Science and Medicine, Graduate School of Medical Sciences, Kyushu University.
Brain research.Brain Res.2013 Apr 18. pii: S0006-8993(13)00535-0. doi: 10.1016/j.brainres.2013.04.022. [Epub ahead of print]
Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) is a well-known pro-inflammatory chemokine and its role in ischemic stroke remains controversial. We examined the significance of RANTES in ischemic stroke and aimed to elucidate the direct effect of RANTES on neurons. Plasma
PMID 23602964

Japanese Journal

Identification of Chemoattractive Factors Involved in the Migration of Bone Marrow-Derived Mesenchymal Stem Cells to Brain Lesions Caused by Prions

Song Chang-Hyun,Honmou Osamu,Furuoka Hidefumi,Horiuchi Motohiro
Journal of Virology 85(21), 11069-11078, 2011-11
… Additionally, hMSCs that had migrated to the right hippocampus of prion-infected mice expressed CCR1, CX3CR1, and CXCR4, implying the involvement of these chemokine receptors in hMSC functions after chemotactic migration. …
NAID 120004027230

Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC chemokine ligand 3/macrophage inflammatory protein-1á

Iida Noriho,Nakamoto Yasunari,Baba Tomohisa,Nakagawa Hidetoshi,Mizukoshi Eishiro,Naito Makoto,Mukaida Naofumi,Kaneko Shuichi
Cancer Research 70(16), 6556-6565, 2010-08-15
… Injection of ECI301 augmented RFA-induced antitumor effect against non-RFA-treated tumors when administered to wild-type or CCR5-deficient but not CCR1-deficient mice. … ECI301 also increased CCR1-expressing CD11c+ cells in peripheral blood and RFA-treated tumors after RFA. … Deficiency of CCR1 impairs accumulation of CD11c+, CD4+, and CD8+ cells in RFA-treated tumors. …
NAID 120002463532

Related Pictures

Fuji Ccr1 Carbon Ultegra Team Powercordz Antibody Target: CCR1

★リンクテーブル★

リンク元	「ケモカインレセプター」
拡張検索	「CCR10受容体」「CCR1受容体」「CCR10 receptor」「CCR1レセプター」「CCR1 receptor」
関連記事	「CC」「CCR」

「ケモカインレセプター」

Chemokine (C-C motif) receptor 1
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1Y5D
Identifiers
Symbols	CCR1 ; CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR; SCYAR1
External IDs	OMIM: 601159 MGI: 104618 HomoloGene: 20344 IUPHAR: 58 ChEMBL: 2413 GeneCards: CCR1 Gene
Gene ontology
Molecular function	• phosphatidylinositol phospholipase C activity; • chemokine receptor activity; • protein binding; • C-C chemokine receptor activity; • C-C chemokine binding; • chemokine (C-C motif) ligand 7 binding; • chemokine (C-C motif) ligand 5 binding;
Cellular component	• cytosol; • plasma membrane; • integral component of plasma membrane; • external side of plasma membrane;
Biological process	• dendritic cell chemotaxis; • calcium ion transport; • cellular calcium ion homeostasis; • exocytosis; • chemotaxis; • inflammatory response; • immune response; • cell adhesion; • cell surface receptor signaling pathway; • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • positive regulation of cytosolic calcium ion concentration; • cell-cell signaling; • response to wounding; • negative regulation of gene expression; • cytokine-mediated signaling pathway; • positive regulation of cell migration; • negative regulation of bone mineralization; • positive regulation of osteoclast differentiation; • positive regulation of calcium ion transport; • chemokine-mediated signaling pathway; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of monocyte chemotaxis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;