WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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1. 骨転移の機序 mechanisms of bone metastases
2. 移植免疫 transplantation immunobiology
3. 慢性関節リウマチにおける滑膜異常 synovial pathology in rheumatoid arthritis
4. RSウイルス感染：臨床的特徴および診断 respiratory syncytial virus infection clinical features and diagnosis
5. 関節リウマチの病因 pathogenesis of rheumatoid arthritis

Functional adaptation of presynaptic chemokine receptors in EAE mouse central nervous system.

Di Prisco S1, Merega E, Pittaluga A.
Synapse (New York, N.Y.).Synapse.2014 Aug 4. doi: 10.1002/syn.21774. [Epub ahead of print]
In cortical synaptosomes of Experimental Autoimmune Encephalomyelitis (EAE) mice at the early stage of disease (13 days post immunization, d.p.i.), the Regulated upon Activation Normal T cell Expressed and Secreted (RANTES, CCL5)-mediated control of [3 H]D-aspartate ([3 H]D-ASP) exocytosis elicited
PMID 25092801

RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice.

Pais R1, Zietek T2, Hauner H3, Daniel H2, Skurk T4.
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2014 Aug 1;307(3):G330-7. doi: 10.1152/ajpgi.00329.2013. Epub 2014 May 29.
Type 2 diabetes is associated with elevated circulating levels of the chemokine RANTES and with decreased plasma levels of the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 is a peptide secreted from intestinal L-cells upon nutrient ingestion. It enhances insulin secretion from pancreatic
PMID 24875103

Neutrophils from pulmonary tuberculosis patients show augmented levels of chemokines MIP-1α, IL-8 and MCP-1 which further increase upon in vitro infection with mycobacterial strains.

Hilda JN1, Narasimhan M2, Das SD3.
Human immunology.Hum Immunol.2014 Aug;75(8):914-22. doi: 10.1016/j.humimm.2014.06.020. Epub 2014 Jun 30.
Neutrophils being innate cells initiate the immune defence against mycobacteria by sending signals to other immune cells. Chemokines being the vital link in signaling processes, it is of interest to study their secretion by neutrophils as a response to tuberculosis infection. The levels of various c
PMID 24994463

杉山昌史,木下浩二,船内正憲
日本臨床免疫学会会誌 38(3), 135-141, 2015
ループス腎炎は全身性エリテマトーデスの重要な臓器合併症の一つである．ネフローゼ症候群や慢性腎臓病などその臨床像は多彩で，時に末期腎不全に進展することもある．病理学的には免疫複合体沈着型糸球体腎炎のことが多いが，病因の一つとしてマクロファージの機能異常，活性化が指摘されており，特に間質に浸潤するマクロファージは組織の線維化をきたし，腎予後について重要な役割を果たすと考えられている．種々のマクロフ …
NAID 130005089218

CCL5/RANTES is important for inducing osteogenesis of human mesenchymal stem cells and is regulated by dexamethasone

Liu Yu-Chuan,Kao Yu-Ting,Huang Wei-Kai,Lin Kun-Yi,Wu Shinn-Chih,Hsu Shu-Ching,C. Schuyler Scott,Li Long-Yuan,Leigh Lu Frank,Lu Jean
BioScience Trends 8(3), 138-143, 2014
… Moreover, the down-regulation of chemokine (C-C motif) receptor 1 (CCR1), one of the CCL5 receptors, significantly decreased the osteogenesis of hMSCs. … Interestingly, the down-regulation of CCR1, but not CCL5, was sufficient to affect the cell numbers during the process of osteogenesis. …
NAID 130004572600

Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model