CXCR5

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/27 16:25:15」(JST)

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Chemokine (C-X-C motif) receptor 5
Identifiers
Symbols	CXCR5 ; BLR1; CD185; MDR15
External IDs	OMIM: 601613 MGI: 103567 HomoloGene: 1298 IUPHAR: CXCR5 ChEMBL: 1075315 GeneCards: CXCR5 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • C-X-C chemokine receptor activity • C-X-C chemokine binding Cellular component • plasma membrane • integral to plasma membrane Biological process • cellular component movement • chemotaxis • immune response • G-protein coupled receptor signaling pathway • elevation of cytosolic calcium ion concentration • B cell activation • lymph node development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	643	12145
Ensembl	ENSG00000160683	ENSMUSG00000047880
UniProt	P32302	Q04683
RefSeq (mRNA)	NM_001716	NM_007551
RefSeq (protein)	NP_001707	NP_031577
Location (UCSC)	Chr 11: 118.75 – 118.77 Mb	Chr 9: 44.51 – 44.56 Mb
PubMed search	[1]	[2]

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.

Tissue distribution and function

The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration.

Clinical significance

CD4⁺CXCR5⁺ expression in T cells protects against mycobacterium tuberculosis (Mtb) infection.

References

Further reading

• Lipp M, Müller G (2006). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking.". Verhandlungen der Deutschen Gesellschaft für Pathologie 87: 90–101. PMID 16888899. 
• Barella L, Loetscher M, Tobler A, et al. (1995). "Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation.". Biochem. J. 309 (3): 773–9. PMC 1135699. PMID 7639692. 
• Legler DF, Loetscher M, Roos RS, et al. (1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416. 
• Gunn MD, Ngo VN, Ansel KM, et al. (1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.". Nature 391 (6669): 799–803. doi:10.1038/35876. PMID 9486651. 
• Müller G, Lipp M (2002). "Signal transduction by the chemokine receptor CXCR5: structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules.". Biol. Chem. 382 (9): 1387–97. doi:10.1515/BC.2001.171. PMID 11688722. 
• Schaerli P, Loetscher P, Moser B (2002). "Cutting edge: induction of follicular homing precedes effector Th cell development.". J. Immunol. 167 (11): 6082–6. doi:10.4049/jimmunol.167.11.6082. PMID 11714765. 
• Kim CH, Johnston B, Butcher EC (2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.". Blood 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001. 
• Carlsen HS, Baekkevold ES, Johansen FE, et al. (2002). "B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue.". Gut 51 (3): 364–71. doi:10.1136/gut.51.3.364. PMC 1773345. PMID 12171958. 
• Battle TE, Yen A (2002). "Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells.". Exp. Biol. Med. (Maywood) 227 (9): 753–62. PMID 12324654. 
• Lisignoli G, Toneguzzi S, Piacentini A, et al. (2003). "Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release.". J. Cell. Physiol. 194 (1): 71–9. doi:10.1002/jcp.10188. PMID 12447991. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Chan CC, Shen D, Hackett JJ, et al. (2003). "Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma.". Ophthalmology 110 (2): 421–6. doi:10.1016/S0161-6420(02)01737-2. PMID 12578791. 
• Flynn G, Maru S, Loughlin J, et al. (2003). "Regulation of chemokine receptor expression in human microglia and astrocytes.". J. Neuroimmunol. 136 (1-2): 84–93. doi:10.1016/S0165-5728(03)00009-2. PMID 12620646. 
• Lisignoli G, Piacentini A, Toneguzzi S, et al. (2004). "Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts.". Biogerontology 4 (5): 309–17. doi:10.1023/A:1026203502385. PMID 14618028. 
• Aust G, Sittig D, Becherer L, et al. (2004). "The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases.". Eur. J. Endocrinol. 150 (2): 225–34. doi:10.1530/eje.0.1500225. PMID 14763921. 
• Howard OM, Dong HF, Su SB, et al. (2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.". Blood 105 (11): 4207–14. doi:10.1182/blood-2004-07-2697. PMC 1895027. PMID 15713799. 
• Steinmetz OM, Panzer U, Kneissler U, et al. (2005). "BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection.". Kidney Int. 67 (4): 1616–21. doi:10.1111/j.1523-1755.2005.00244.x. PMID 15780119. 
• Hu C, Xiong J, Zhang L, et al. (2006). "PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia.". Cell. Mol. Immunol. 1 (4): 280–94. PMID 16225771. 

UpToDate Contents

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English Journal

• Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.

• Kiguchi N1, Ding H2, Peters CM3, Kock ND4, Kishioka S5, Cline JM4, Wagner JD4, Ko MC6.
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• Circulating CXCR5+CD4+ T cells assist in the survival and growth of primary diffuse large B cell lymphoma cells through interleukin 10 pathway.

• Cha Z1, Qian G2, Zang Y1, Gu H1, Huang Y1, Zhu L1, Li J1, Liu Y1, Tu X1, Song H3, Qian B4.
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• Chronic HIV-1 Infection Impairs Superantigen-Induced Activation of Peripheral CD4+CXCR5+PD-1+ Cells, With Relative Preservation of Recall Antigen-Specific Responses.

• Nicholas KJ1, Flaherty DK, Smith RM, Sather DN, Kalams SA.
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• Peripheral CD4+CXCR5+PD-1+ T cells are a putative circulating counterpart to germinal center T follicular helper (TFH) cells. They show both phenotypic and functional similarities to TFH cells, which provide necessary help for the differentiation of B cells to antibody-secreting plasmablasts. In thi
• PMID 27509243

Japanese Journal

• P1-06　TCR signalの異常とループス

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• 日本臨床免疫学会会誌 39(4), 378a-378a, 2016
• NAID 130005407792

Related Pictures

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★リンクテーブル★

リンク元	「ケモカインレセプター」
拡張検索	「CXCR5受容体」「CXCR5レセプター」「CXCR5 receptor」

「ケモカインレセプター」

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英

chemokine receptor

関

ケモカインレセプター (IMM.86)

CXCR
	CXCR1
	CXCR2
	CXCR3
	CXCR4
	CXCR5
CCR
	CCR1
	CCR2B
	CCR3
	CCR5

「CXCR5受容体」

　　[★]

英

CXCR5 receptor

関

CXCR5レセプター

「CXCR5レセプター」

　　[★]

英

CXCR5 receptor

関

CXCR5受容体

「CXCR5 receptor」

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• CXCR5受容体、CXCR5レセプター