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1. アレルギー性鼻炎および結膜炎に対する補完代替療法 complementary and alternative therapies for allergic rhinitis and conjunctivitis
2. ハーブ剤および栄養補助食品による肝毒性 hepatotoxicity due to herbal medications and dietary supplements

English Journal

Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-α in High-Fat-Diet-Induced Obese Rats.

Tzeng TF, Lu HJ, Liou SS, Chang CJ, Liu IM.SourceDepartment of Internal Medicine, Pao Chien Hospital, Pingtung City, Pingtung County 90065, Taiwan.
Evidence-based complementary and alternative medicine : eCAM.Evid Based Complement Alternat Med.2012;2012:827278. Epub 2011 Dec 27.
The aim of this study was to investigate the antiobesity and antihyperlipidemic effects of vinegar-baked Radix Bupleuri (VBRB) on high-fat diet- (HFD-) induced obese rats. After being fed HFD for two weeks, rats were dosed orally with VBRB or fenofibrate, once daily for further twelve weeks. VBRB (1
PMID 22253647

Species discrimination of Radix Bupleuri through the simultaneous determination of ten saikosaponins by high performance liquid chromatography with evaporative light scattering detection and electrospray ionization mass spectrometry.

Lee J, Yang DH, Suh JH, Kim U, Eom HY, Kim J, Lee MY, Kim J, Han SB.SourceDepartment of Pharmaceutical Analysis, College of Pharmacy, Chung-Ang University, Seoul, South Korea.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2011 Dec 15;879(32):3887-95. Epub 2011 Nov 4.
A simple, rapid and robust high performance liquid chromatography-evaporative light scattering detection (HPLC-ELSD) method was established for the species discrimination and quality evaluation of Radix Bupleuri through the simultaneous determination of ten saikosaponins, namely saikosaponin-a, -b(1
PMID 22105022

Interaction of the main components from the traditional Chinese drug pair Chaihu-Shaoyao based on rat intestinal absorption.

Chen Y, Wang J, Yuan L, Zhou L, Jia X, Tan X.SourceKey Laboratory of New Drug Delivery System of Chinese Material Medica, Jiangsu Province, Academy of Chinese Medicine, 100 Shizi Road, Nanjing 210028, China. ychen202@yahoo.com.cn
Molecules (Basel, Switzerland).Molecules.2011 Nov 17;16(11):9600-10.
The Chaihu-Shaoyao drug pair (Bupleuri Radix and Paeoniae Radix Alba) which is a traditional Chinese drug pair, has been widely used for anti-inflammatory purposes. Saikosaponin a (SSA), saikosaponin d (SSD) and paeoniflorin are identified as the main components in the pair. The present study focuse
PMID 22095024

Suppression of murine colitis by Kampo medicines, with special reference to the efficacy of saireito

Endo Mari,及川哲郎,HOSHINO Takayuki,HATORI Tsutomu,MATSUMOTO Tsukasa,HANAWA Toshihiko
和漢医薬学雑誌 26(3), 110-121, 2009-08-31
漢方薬は潰瘍性大腸炎(UC)を含む慢性の炎症性疾患に広く用いられている。黄連解毒湯とその構成生薬である黄苓がデキストラン硫酸ナトリウム(DSS)誘発マウス大腸炎を抑制することが報告されているが、その他の処方でもこのモデルで有効性を示すのかは明らかではない。また、黄苓などの特定生薬を除いたいわゆる一味抜き処方での検討も報告されていない。そこで、このモデルにおいて13種類の漢方処方の抗炎症活性を検討し …
NAID 110007356323

Blockade of the Dioxin Pathway by Herbal Medicine Formula Bupleuri Minor : Identification of Active Entities for Suppression of AhR Activation(Molecular and Cell Biology)

Kasai Ayumi,Hiramatsu Nobuhiko,Hayakawa Kunihiro [他],YAO Jian,KITAMURA Masanori
Biological & pharmaceutical bulletin 31(5), 838-846, 2008-05-01
… We found that only Formula bupleuri minor (TJ-9) significantly inhibited activation of AhR by 2,3,7,8-tetrachlorodibenzo-p-dioxin. … Among 7 raw herb extracts in TJ-9, Glycyrrhizae Radix and Scutellariae Radix were responsible for the antagonistic effect of TJ-9 against dioxin. … Some constituents including Bupleuri Radix and Zingiberis Rhizoma rather activated AhR. …
NAID 110006663938

Eastern blotting and use of anti-saikosaponin a monoclonal antibodies for detection of saikosaponins

Zhu Shu-hang,Morinaga Osamu,Shimokawa Shinichi [他],SHON Tae Kwon,LEE Sang Chul,SHOYAMA Yukihiro,TANAKA Hiroyuki
Journal of natural medicines 61(2), 178-183, 2007-05-20
NAID 10018832783