WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
coming to full development; becoming mature (同)ripening, maturement

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
抗原(生物の体内にはいって免疫体を作る物質)
成熟,円熟

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/16 19:06:45」(JST)

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B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.

TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).^[1]^[2]^[3]

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.^[3]

Interactions

TNFRSF17 has been shown to interact with the B-cell activating factor TNFSF13B.^[4]^[5] A conserved domain at the N-terminus, BCMA TALL-1 binding domain, is required for binding to the TNFSF13B.^[4]

Diseases

TNFRSF17 is implicated in leukemia, lymphomas, and multiple myeloma ^[6] (see the "Mitelman Database" ^[7] and the Atlas of Genetics and Cytogenetics in Oncology and Haematology,^[8]).

References

^ Laâbi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A (Nov 1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma". The EMBO Journal 11 (11): 3897–904. PMC 556899. PMID 1396583.
^ Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (Apr 1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed". Nucleic Acids Research 22 (7): 1147–54. doi:10.1093/nar/22.7.1147. PMC 523635. PMID 8165126.
^ ^a ^b "Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17".
^ ^a ^b Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G (May 2003). "Ligand-receptor binding revealed by the TNF family member TALL-1". Nature 423 (6935): 49–56. doi:10.1038/nature01543. PMID 12721620.
^ Shu HB, Johnson H (Aug 2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 9156–61. doi:10.1073/pnas.160213497. PMC 16838. PMID 10908663.
^ http://atlasgeneticsoncology.org/Genes/TNFRSF17ID42616ch16p13.html
^ "Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer".
^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

UpToDate Contents

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1. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
2. 体液性免疫応答 the humoral immune response
3. 抗原提示細胞 antigen presenting cells
4. びまん性大細胞型B細胞性リンパ腫および原発性縦隔大細胞型B細胞リンパ腫の病理学 pathobiology of diffuse large b cell lymphoma and primary mediastinal large b cell lymphoma
5. 胎児および新生児における免疫細胞の発達 the development of immune cells in the fetus and neonate

English Journal

γ-secretase directly sheds the survival receptor BCMA from plasma cells.

Laurent SA1, Hoffmann FS1, Kuhn PH2, Cheng Q3, Chu Y4, Schmidt-Supprian M4, Hauck SM5, Schuh E1, Krumbholz M1, Rübsamen H1, Wanngren J2, Khademi M6, Olsson T6, Alexander T3, Hiepe F3, Pfister HW7, Weber F8, Jenne D9, Wekerle H10, Hohlfeld R11, Lichtenthaler SF12, Meinl E1.
Nature communications.Nat Commun.2015 Jun 11;6:7333. doi: 10.1038/ncomms8333.
Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ-secretase directly cleaves BCMA, without prior truncation by another protease. This direct shedding is facilitated by the short
PMID 26065893

CD1d-dependent endogenous and exogenous lipid antigen presentation.

McEwen-Smith RM1, Salio M1, Cerundolo V2.
Current opinion in immunology.Curr Opin Immunol.2015 Jun;34:116-125. doi: 10.1016/j.coi.2015.03.004. Epub 2015 Mar 23.
Invariant natural killer T (iNKT) cells recognize endogenous and exogenous lipids in the context of CD1d molecules, and through the activation and maturation of dendritic cells and B cells, can significantly enhance priming of antigen-specific T and B cell responses. Recent findings have provided im
PMID 25805574

Impaired antigen-specific immune response to vaccines in children with antibody production defects.

Szczawinska-Poplonyk A1, Breborowicz A2, Samara H3, Ossowska L2, Dworacki G3.
Clinical and vaccine immunology : CVI.Clin Vaccine Immunol.2015 May 27. pii: CVI.00148-15. [Epub ahead of print]
INTRODUCTION: The impaired synthesis of antigen-specific antibodies, which is indispensable for an adaptive immune response to infections, is a fundamental pathomechanism that leads to clinical manifestations in children with antibody production defects. The aim of the study was to evaluate the synt
PMID 26018535

Japanese Journal

自己抗体産生RP105陰性B細胞上に発現する B-cell maturation antigen は, 全身性エリテマトーデスの治療標的となりうるか

小荒田秀一,田代知子,末松梨絵,井上久子,大田明英,多田芳史
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 35(1), 38-45, 2012-02-28
… The molecule is expressed on mature B cells. … Significantly increased population of RP105-negative [RP105(－)] B cells is found in SLE. … RP105(－) B cells belong to highly activated and differentiated late B cells and produce autoantibodies including anti-dsDNA antibodies. … RP105(－) B cells are further divided into at least 5 subsets that include novel human B cell subsets. …
NAID 10030465586

培養B細胞株を用いるIn vitro抗体作製システムによる有用抗体の創製(誌上シンポジウム)

金山直樹,藤堂景史,曲正樹 [他],大森齊
藥學雜誌 129(1), 11-17, 2009-01-01
… The generation of hybridomas from antigen-stimulated B cells has been a key technology for obtaining mAbs; … We have been attempting to develop a novel in vitro antibody generation system using a chicken B cell line DT40, which displays Abs and mutates Ig genes during culture, thereby generating a useful Ab library for screening mAbs. …
NAID 110007028560

BAFFと自己免疫性疾患

松下貴史,佐藤伸一,Matsushita Takashi,Sato Shinichi
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 28(5), 333-342, 2005-10-31
… B細胞の生存・分化・抗体産生に重要な役割を果たすBAFF (B cell activating factor belonging to the tumor necrosis factor family）はTNFファミリーに属する分子で単球，マクロファージ，樹状細胞の細胞膜上に発現され，可溶型として分泌される．BAFFの受容体にはBAFF-R (BAFF receptor), BCMA (B-cell maturation antigen）およびTACI …
NAID 10016912364

「B細胞成熟抗原」

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

BCMA TALL-1 binding domain
	crystal structure of stall-1 and bcma
Identifiers
Symbol	BCMA-Tall_bind
Pfam	PF09257
InterPro	IPR015337
SCOP	1oqd
SUPERFAMILY	1oqd
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Tumor necrosis factor receptor superfamily, member 17
	PDB rendering based on 1oqd.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1OQD, 1XU2, 2KN1, 4ZFO
Identifiers
Symbols	TNFRSF17 ; BCM; BCMA; CD269; TNFRSF13A
External IDs	OMIM: 109545 MGI: 1343050 HomoloGene: 920 GeneCards: TNFRSF17 Gene
Gene ontology
Molecular function	• receptor activity;
Cellular component	• plasma membrane; • endomembrane system; • integral component of membrane;
Biological process	• adaptive immune response; • lymphocyte homeostasis; • signal transduction; • multicellular organismal development; • cell proliferation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;