WordNet

of southern Europe; similar to but smaller than the adder (同)asp viper, Vipera aspis
cobra used by the Pharaohs as a symbol of their power over life and death (同)Egyptian cobra, Naja_haje
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
matter that remains after something has been removed

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Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis.

Hamza T1, Zhang Z2, Melnyk RA3, Feng H4.
Pathogens and disease.Pathog Dis.2016 Feb;74(1). pii: ftv098. doi: 10.1093/femspd/ftv098. Epub 2015 Oct 26.
The Clostridium difficile toxin B is one of the main virulence factors and plays an important role in the pathogenesis of C. difficile infection (CDI). We recently revealed crucial residues in the translocation domain of TcdB for the pore formation and toxin translocation. In this study, we investig
PMID 26507679

FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy.

Olsvik HL1, Lamark T1, Takagi K2, Larsen KB1, Evjen G1, Øvervatn A1, Mizushima T2, Johansen T3.
The Journal of biological chemistry.J Biol Chem.2015 Dec 4;290(49):29361-74. doi: 10.1074/jbc.M115.686915. Epub 2015 Oct 14.
FYCO1 (FYVE and coiled-coil protein 1) is a transport adaptor that binds to phosphatidylinositol 3-phosphate, to Rab7, and to LC3 (microtubule-associated protein 1 light chain 3) to mediate transport of late endosomes and autophagosomes along microtubules in the plus end direction. We have previousl
PMID 26468287

A new group of eubacterial light-driven retinal-binding proton pumps with an unusual cytoplasmic proton donor.

Harris A1, Ljumovic M1, Bondar AN2, Shibata Y3, Ito S3, Inoue K4, Kandori H5, Brown LS6.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Dec;1847(12):1518-29. doi: 10.1016/j.bbabio.2015.08.003. Epub 2015 Aug 7.
One of the main functions of microbial rhodopsins is outward-directed light-driven proton transport across the plasma membrane, which can provide sources of energy alternative to respiration and chlorophyll photosynthesis. Proton-pumping rhodopsins are found in Archaea (Halobacteria), multiple group
PMID 26260121

中井隆一郎,藤野志保子,内海友宏,田村隆,日下部均,稲垣賢二
岡山大学農学部学術報告 103, 5-9, 2014-02-01
… Recently, we solved the X‒ray crystal structure of LGOX and this revealed that Arg305 inthe active site is the key residue involved in substrate recognition. … One of them R305D‒LGOX, Arg305 substitutedwith Asp exhibited oxidase activity for L‒Arg. …
NAID 120005367628

Involvement of Val 315 located in the C-terminal region of thermolysin in its expression in Escherichia coli and its thermal stability.

Kojima Kenji,Nakata Hiroki,Inouye Kuniyo
Biochimica et biophysica acta -Proteins and Proteomics 1844(2), 330-338, 2014-02
… The C-terminal Lys316 residue was not significant in the expression, but Val315 was critical. … Variants with charged (Asp, Glu, Lys, and Arg), bulky (Trp), or small (Gly) amino acids were lower in these characteristics than WT. …
NAID 120005359199

Racemization of the Aspartic Acid Residue of Amyloid-β Peptide by a Radical Reaction

TAMBO Koharu,YAMAGUCHI Tomomi,KOBAYASHI Keiko,TERAUCHI Eri,ICHI Ikuyo,KOJO Shosuke
Bioscience, Biotechnology, and Biochemistry 77(2), 416-418, 2013
… The percentage of D-aspartic acid (D-Asp) after 24 h had increased to 6.69 ± 0.09%, this being comparable with the reported D-Asp concentration of purified core amyloids in Alzheimer's disease patients. …
NAID 130004138051