アムホテリシンB
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/16 03:14:00」(JST)
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| Amphiphysin |
Rendering of 1KY7 |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
1KY7, 1UTC, 3SOG, 4ATM
|
|
|
| Identifiers |
| Symbols |
AMPH ; AMPH1 |
| External IDs |
OMIM: 600418 MGI: 103574 HomoloGene: 121585 GeneCards: AMPH Gene |
| Gene ontology |
| Molecular function |
• protein binding
• phospholipid binding
|
| Cellular component |
• synaptic vesicle
• actin cytoskeleton
• cell junction
• synaptic vesicle membrane
• leading edge membrane
|
| Biological process |
• endocytosis
• synaptic transmission
• learning
• synaptic vesicle endocytosis
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
273 |
218038 |
|
| Ensembl |
ENSG00000078053 |
ENSMUSG00000021314 |
|
| UniProt |
P49418 |
Q7TQF7 |
|
| RefSeq (mRNA) |
NM_001635 |
NM_001289546 |
|
| RefSeq (protein) |
NP_001626 |
NP_001276475 |
|
| Location (UCSC) |
Chr 7:
38.42 – 38.67 Mb |
Chr 13:
18.95 – 19.15 Mb |
|
| PubMed search |
[1] |
[2] |
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|
|
Amphiphysin is a protein that in humans is encoded by the AMPH gene.[1][2]
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff person syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.[2]
Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of dynamin to sites of clathrin-mediated endocytosis. There are 2 mammalian amphiphysins with similar overall structure. A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in muscle tissue and is involved in the formation and stabilization of the T-tubule network. In other tissues amphiphysin is likely involved in other membrane bending and curvature stabilization events.
Contents
- 1 Interactions
- 2 See also
- 3 References
- 4 Further reading
- 5 External links
Interactions
Amphiphysin has been shown to interact with DNM1,[3][4][5][6][7] Phospholipase D1,[8] CDK5R1,[9] PLD2,[8] CABIN1[10] and SH3GL2.[3][11]
See also
References
- ^ De Camilli, P.; Thomas, A; Cofiell, R; Folli, F; Lichte, B; Piccolo, G; Meinck, HM; Austoni, M et al. (December 1993). "The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer". J Exp Med 178 (6): 2219–23. doi:10.1084/jem.178.6.2219. PMC 2191289. PMID 8245793.
- ^ a b "Entrez Gene: AMPH amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)".
- ^ a b Micheva, K. D.; Kay, BK; McPherson, PS (October 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. PMID 9341169.
- ^ Wigge, P; Köhler, K; Vallis, Y; Doyle, CA; Owen, D; Hunt, SP; McMahon, HT (October 1997). "Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis". Mol. Biol. Cell 8 (10): 2003–15. doi:10.1091/mbc.8.10.2003. PMC 25662. PMID 9348539.
- ^ McMahon, Harvey T; Wigge, Patrick; Smith, Corrin (August 1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin". FEBS Lett. 413 (2): 319–22. doi:10.1016/S0014-5793(97)00928-9. PMID 9280305.
- ^ Chen-Hwang, M.-C.; Chen, HR; Elzinga, M; Hwang, YW (May 2002). "Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate". J. Biol. Chem. 277 (20): 17597–604. doi:10.1074/jbc.M111101200. PMID 11877424.
- ^ Grabs, D.; Slepnev, VI; Songyang, Z; David, C; Lynch, M; Cantley, LC; De Camilli, P (May 1997). "The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence". J. Biol. Chem. 272 (20): 13419–25. doi:10.1074/jbc.272.20.13419. PMID 9148966.
- ^ a b Lee, C.; Kim, SR; Chung, JK; Frohman, MA; Kilimann, MW; Rhee, SG (June 2000). "Inhibition of phospholipase D by amphiphysins". J. Biol. Chem. 275 (25): 18751–8. doi:10.1074/jbc.M001695200. PMID 10764771.
- ^ Floyd, S. R.; Porro, EB; Slepnev, VI; Ochoa, GC; Tsai, LH; De Camilli, P (March 2001). "Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2". J. Biol. Chem. 276 (11): 8104–10. doi:10.1074/jbc.M008932200. PMID 11113134.
- ^ Lai, M. M.; Luo, HR; Burnett, PE; Hong, JJ; Snyder, SH (November 2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
- ^ Modregger, J.; Schmidt, AA; Ritter, B; Huttner, WB; Plomann, M (February 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. 278 (6): 4160–7. doi:10.1074/jbc.M208568200. PMID 12456676.
Further reading
- Lichte, B; Veh, RW; Meyer, HE; Kilimann, MW (1992). "Amphiphysin, a novel protein associated with synaptic vesicles". EMBO J. 11 (7): 2521–30. PMC 556727. PMID 1628617.
- Yamamoto, Raina; Li, Xu; Winter, Silke; Francke, Uta; Kilimann, Manfred W. (1995). "Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14". Hum. Mol. Genet. 4 (2): 265–8. doi:10.1093/hmg/4.2.265. PMID 7757077.
- David, C; Solimena, M; Decamilli, P (1994). "Autoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161". FEBS Lett. 351 (1): 73–9. doi:10.1016/0014-5793(94)00826-4. PMID 8076697.
- David, C.; McPherson, PS; Mundigl, O; De Camilli, P (1996). "A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 331–5. doi:10.1073/pnas.93.1.331. PMC 40232. PMID 8552632.
- Grabs, D.; Slepnev, VI; Songyang, Z; David, C; Lynch, M; Cantley, LC; De Camilli, P (1997). "The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence". J. Biol. Chem. 272 (20): 13419–25. doi:10.1074/jbc.272.20.13419. PMID 9148966.
- Butler, M. H.; David, C; Ochoa, GC; Freyberg, Z; Daniell, L; Grabs, D; Cremona, O; De Camilli, P (1997). "Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle". J. Cell Biol. 137 (6): 1355–67. doi:10.1083/jcb.137.6.1355. PMC 2132527. PMID 9182667.
- Ramjaun, A. R.; Micheva, KD; Bouchelet, I; McPherson, PS (1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform". J. Biol. Chem. 272 (26): 16700–6. doi:10.1074/jbc.272.26.16700. PMID 9195986.
- McMahon, Harvey T; Wigge, Patrick; Smith, Corrin (1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin". FEBS Lett. 413 (2): 319–22. doi:10.1016/S0014-5793(97)00928-9. PMID 9280305.
- Micheva, Kristina D.; Ramjaun, Antoine R.; Kay, Brian K.; McPherson, Peter S. (1997). "SH3 domain-dependent interactions of endophilin with amphiphysin". FEBS Lett. 414 (2): 308–12. doi:10.1016/S0014-5793(97)01016-8. PMID 9315708.
- Wigge, P; Köhler, K; Vallis, Y; Doyle, CA; Owen, D; Hunt, SP; McMahon, HT (1997). "Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis". Mol. Biol. Cell 8 (10): 2003–15. doi:10.1091/mbc.8.10.2003. PMC 25662. PMID 9348539.
- Floyd, S; Butler, MH; Cremona, O; David, C; Freyberg, Z; Zhang, X; Solimena, M; Tokunaga, A et al. (1998). "Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer". Mol. Med. 4 (1): 29–39. PMC 2230265. PMID 9513187.
- Ramjaun, Antoine R.; McPherson, Peter S. (1998). "Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites". J. Neurochem. 70 (6): 2369–76. doi:10.1046/j.1471-4159.1998.70062369.x. PMID 9603201.
- Slepnev, V. I.; Ochoa, GC; Butler, MH; Grabs, D; De Camilli, P (1998). "Role of phosphorylation in regulation of the assembly of endocytic coat complexes". Science 281 (5378): 821–4. doi:10.1126/science.281.5378.821. PMID 9694653.
- Cestra, G.; Castagnoli, L; Dente, L; Minenkova, O; Petrelli, A; Migone, N; Hoffmüller, U; Schneider-Mergener, J; Cesareni, G (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity". J. Biol. Chem. 274 (45): 32001–7. doi:10.1074/jbc.274.45.32001. PMID 10542231.
- Slepnev, V. I.; Ochoa, GC; Butler, MH; De Camilli, P (2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites". J. Biol. Chem. 275 (23): 17583–9. doi:10.1074/jbc.M910430199. PMID 10748223.
- Lee, C.; Kim, SR; Chung, JK; Frohman, MA; Kilimann, MW; Rhee, SG (2000). "Inhibition of phospholipase D by amphiphysins". J. Biol. Chem. 275 (25): 18751–8. doi:10.1074/jbc.M001695200. PMID 10764771.
- Onofri, F.; Giovedi, S; Kao, HT; Valtorta, F; Bongiorno Borbone, L; De Camilli, P; Greengard, P; Benfenati, F (2000). "Specificity of the binding of synapsin I to Src homology 3 domains". J. Biol. Chem. 275 (38): 29857–67. doi:10.1074/jbc.M006018200. PMID 10899172.
- Lai, M. M.; Luo, HR; Burnett, PE; Hong, JJ; Snyder, SH (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
- Floyd, S. R.; Porro, EB; Slepnev, VI; Ochoa, GC; Tsai, LH; De Camilli, P (2001). "Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2". J. Biol. Chem. 276 (11): 8104–10. doi:10.1074/jbc.M008932200. PMID 11113134.
- a. Leventis, Peter; m. Chow, Brenda; Stewart, Bryan A.; Iyengar, Balaji; Campos, Ana Regina; Boulianne, Gabrielle L. (2001). "Drosophila Amphiphysin is a post-synaptic protein required for normal locomotion but not endocytosis". Traffic. 2 (11): 839–50. doi:10.1034/j.1600-0854.2001.21113.x. PMID 11733051.
- Zhang, Bing; Zelhof, Andrew C. (2002). "Amphiphysins: raising the BAR for synaptic vesicle recycling and membrane dynamics". Traffic. 3 (7): 452–60. doi:10.1034/j.1600-0854.2002.30702.x. PMID 12047553. Review.
- Zelhof, AC; Bao, H; Hardy, RW; Razzaq, A; Zhang, B; Doe, CQ (2001). "Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis". Development 128 (24): 5005–15. PMID 11748137.
- Mathew, D; Popescu, A; Budnik, V (2003). "Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling". J Neurosci. 23 (33): 10710–6. PMID 14627656.
External links
- Bringing your curves to the bar, amphiphysin home page
- De Camilli, Pietro; Takei, Kohji; Slepnev, Vladimir I.; Haucke, Volker (May 1999). "Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis". Nat. Cell Biol. 1 (1): 33–9. doi:10.1038/9004. PMID 10559861.
- Peter, B. J.; Kent, HM; Mills, IG; Vallis, Y; Butler, PJ; Evans, PR; McMahon, HT (January 2004). "BAR domains as sensors of membrane curvature: the amphiphysin BAR structure". Science 303 (5657): 495–9. doi:10.1126/science.1092586. PMID 14645856.
- Evergren, Emma; Marcucci, Melissa; Tomilin, Nikolay; Löw, Peter; Slepnev, Vladimir; Andersson, Fredrik; Gad, Helge; Brodin, Lennart et al. (July 2004). "Amphiphysin is a component of clathrin coats formed during synaptic vesicle recycling at the lamprey giant synapse". Traffic 5 (7): 514–28. doi:10.1111/j.1398-9219.2004.00198.x. PMID 15180828.
- Razzaq, A.; Robinson, IM; McMahon, HT; Skepper, JN; Su, Y; Zelhof, AC; Jackson, AP; Gay, NJ; O'Kane, CJ (November 2001). "Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila". Genes Dev. 15 (22): 2967–79. doi:10.1101/gad.207801. PMC 312829. PMID 11711432.
English Journal
- Methamphetamine-, d-Amphetamine-, and p-Chloroamphetamine-Induced Neurotoxicity Differentially Effect Impulsive Responding on the Stop-Signal Task in Rats.
- Furlong TM1, Leavitt LS2, Keefe KA2, Son JH2.
- Neurotoxicity research.Neurotox Res.2016 May;29(4):569-582. Epub 2016 Feb 4.
- Abused amphetamines, such as d-amphetamine (AMPH) and methamphetamine (METH), are highly addictive and destructive to health and productive lifestyles. The abuse of these drugs is associated with impulsive behavior, which is likely to contribute to addiction. The amphetamines also differentially dam
- PMID 26846719
- m-Trifluoromethyl-diphenyldiselenide as a pharmacological tool to treat preference symptoms related to AMPH-induced dependence in rats.
- Segat HJ1, Martini F1, Barcelos RC2, Brüning CA1, Nogueira CW3, Burger ME4.
- Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2016 Apr 3;66:1-7. doi: 10.1016/j.pnpbp.2015.11.002. Epub 2015 Nov 10.
- Amphetamine (AMPH) abuse is a world concern and a serious public health problem. Repeated administration of high doses of AMPH induces neuropsychiatric consequences, including addiction, reward and psychosis, whose pharmacological treatment has shown limited effectiveness. The m-trifluoromethyl-diph
- PMID 26555614
- Amphetamine elevates nucleus accumbens dopamine via an action potential-dependent mechanism that is modulated by endocannabinoids.
- Covey DP1, Bunner KD2, Schuweiler DR3, Cheer JF1,4, Garris PA3.
- The European journal of neuroscience.Eur J Neurosci.2016 Apr 2. doi: 10.1111/ejn.13248. [Epub ahead of print]
- Reinforcing effects of abused drugs are mediated by their ability to elevate nucleus accumbens dopamine. Amphetamine (AMPH) is historically thought to increase dopamine by an action potential-independent, non-exocytotic type of release called efflux, involving reversal of dopamine transporter functi
- PMID 27038339
Japanese Journal
- Liposomal-Amphotericin Bによる腎機能低下発現における要因解析
- 齋藤 佑輔,堀田 栄治,上阪 友基,林 由紀子,海崎 佳史,細田 清美,高嶋 孝次郎,藤澤 克憲
- 医療薬学 40(2), 94-99, 2014
- … There is less emergence of renal toxicity in Liposomal-amphotericin B (L-AMB) than amphotericin B (AMPH-B). …
- NAID 130004894841
- Bibliographical Investigation (Domestic and Overseas) on the Treatment of Endogenous <I>Candida</I> Endophthalmitis over an 11-Year Period
- , , , , , ,
- Medical Mycology Journal 54(1), 53-67, 2013
- … Reports from overseas, on the other hand, suggested the effectiveness of amphotericin B (AMPH-B) or voriconazole (VRCZ) therapy for stage II cases, and of vitrectomy for stage III and IV cases. …
- NAID 130004971100
- ヒト歯肉線維芽細胞からの炎症性サイトカイン産生に対するamphotericinBの修飾作用
- 小林 良誌,玉井 利代子,清浦 有祐
- 奥羽大学歯学誌 39巻(2号), 87-94, 2012-06
- … 歯周病原性細菌の一種でヒトの口腔内に多く存在するFusobacterium nucleatumに対するヒト歯肉線維芽細胞の宿主応答に及ぼすアンフォテリシンB(AMPH)の影響を炎症性サイトカインの産生に焦点を当てて解明することを試みた。 … F.nucleatumの刺激により歯肉線維芽細胞からの産生が認められたIL-6、IL-8、単球走化性タンパク質-1(MCP-1)の中で、MCP-1のみがAMPHにより産生が抑制された。 …
- NAID 120005470363
Related Links
- AMPHI（アンフィ）はワコール発の下着セレクトショップ。いつでも'新しいかわいい'ランジェリーが見つかるインナーウェアの新しいカタチ、AMPHIです。 ... 重要なお知らせ 「tocco」ルームウェア（株式会社ペーターズ製）の洗濯絵表示 ...
- ... ～ 19:00 TEL、メールにて日程をご相談ください AMP姫路市下手野2-4-16079-292-7550info@amph.net 2014/04/01 information スタッフ募集 2014/05/08 AMP Recommend 今回のレコメンド『アインとシュタイン』 2014/04/09 今回の ...
Related Pictures
★リンクテーブル★
[★]
- 英
- amphotericin B, AMPH-B, AMPH
- ラ
- amphotericinum-B
- 商
- ファンギゾン、ハリゾン、アムビゾーム Ambisome, Amphocil, Amphotec
- 関
- 抗真菌薬、ポリエンマクロライド系抗生物質、アムホテリシンBリポソーム製剤
- 腎毒性
[★]
アムホテリシンB amphotericin B
[★]
[★]
アデノシン一リン酸 adenosine monophosphate adenosine 5'-monophosphate