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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/25 06:16:17」(JST)

20α-ヒドロキシステロイドデヒドロゲナーゼ（20α-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。

17α,20α-ジヒドロキシプレグン-4-エン-3-オン + NAD(P)+ 17α-ヒドロキシプロゲステロン + NAD(P)H + H⁺

反応式の通り、この酵素の基質は17α,20α-ジヒドロキシプレグン-4-エン-3-オンとNAD(P)⁺、生成物は17α-ヒドロキシプロゲステロンとNAD(P)HとH⁺である。

組織名は20α-hydroxysteroid:NAD(P)⁺ 20-oxidoreductaseで、別名に20α-hydroxy steroid dehydrogenase, 20α-HSD, 20α-HSDHがある。

参考文献[編集]

Shikita M, Inano H, Tamaoki B (1967). “Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes”. Biochemistry. 6: 1760–4. doi:10.1021/bi00858a026. PMID 4382486.
Strickler RC, Tobias B, Covey DF (1981). “Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site”. J. Biol. Chem. 256: 316–21. PMID 6935192.
Wiest WG, Kidwell WR, Balogh K (April 1968). “Progesterone catabolism in the rat ovary: a regulatory mechanism for progestational potency during pregnancy”. Endocrinology 82 (4): 844–59. PMID 5742200.

Wiest WG (December 1968). “On the function of 20 alpha-hydroxypregn-4-en-3-one during parturition in the rat”. Endocrinology 83 (6): 1181–4. PMID 5721991.

Piekorz RP, Gingras S, Hoffmeyer A, Ihle JN, Weinstein Y (February 2005). “Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase”. Mol. Endocrinol. 19 (2): 431–40. doi:10.1210/me.2004-0302. PMID 15471942.

Akinola LA, Poutanen M, Vihko R, Vihko P (July 1997). “Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats”. Endocrinology 138 (7): 2886–92. PMID 9202232.

Weinstein Y (October 1977). “20alpha-hydroxysteroid dehydrogenase: a T lymphocyte-associated enzyme”. J. Immunol. 119 (4): 1223–9. PMID 302277.

Weinstein Y, Lindner HR, Eckstein B (April 1977). “Thymus metabolises progesterone- possible enzymatic marker for T lymphocytes”. Nature 266 (5603): 632–3. PMID 300849.

Ihle JN, Keller J, Oroszlan S, Henderson LE, Copeland TD, Fitch F, Prystowsky MB, Goldwasser E, Schrader JW, Palaszynski E, Dy M, Lebel B (July 1983). “Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity”. J. Immunol. 131 (1): 282–7. PMID 6190911.

Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y (March 2007). “Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone”. Endocrinology 148 (3): 976–88. doi:10.1210/en.2006-1100. PMID 17122075.

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リンク元	「20α水酸化ステロイド脱水素酵素」「20α-水酸化ステロイド脱水素酵素」「20alpha-hydroxysteroid dehydrogenase」「20α-ヒドロキシステロイド脱水素酵素」
関連記事	「ヒドロキシステロイドデヒドロゲナーゼ」「ステロイド」「ヒドロキシ」「ヒドロ」